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DIRECT NUMERICAL SIMULATION OF THE INTRA-VENTRICULAR FLOW USING PATIENT-SPECIFIC ANATOMY

Trung Le
St. Anthony Falls Lab. Department of Civil Engineering University of Minnesota 2 Third Avenue SE

Iman Borazjani
St. Anthony Falls Laboratory, University of Minnesota; Mechanical and Aerospace Engineering Department, University at Buffalo, State University of New York, Buffalo, NY 14260

Fotis Sotiropoulos
School of Civil and Environmental Engineering Georgia Institute of Technology Atlanta, GA 30332-0355 USA; St. Anthony Falls Laboratory, Department of Civil Engineering University of Minnesota 2 Third Avenue SE, Minneapolis, MN 55414, USA

Аннотация

A novel computational framework for performing high resolution simulation of intraventricular flow in a patient-specific left heart is developed. The left heart anatomy is reconstructed from magnetic resonance imaging (MRI) data. We develop a physiologic cell activation model for the left ventricle kinematics and prescribe the resulting wall motion as the boundary condition for intraventricular flow simulation. The left ventricle is treated with sharp-interface immersed boundary to handle the large deformation of the wall motion. The simulations reveal the complexity of the flow structure during diastolic filling inside the LV chamber due to the formation and breakups of the vortex ring at the mitral orifice. The current framework demonstrates promising capabilities to evolve into a predictive tool for clinical uses.