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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Efficacy of Curcumin in Ameliorating Aluminum- Induced Neurotoxicity

卷 37, 册 2, 2018, pp. 163-172
DOI: 10.1615/JEnvironPatholToxicolOncol.2018026437
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摘要

Background−The present study evaluated the efficacy of curcumin as a nutritional supplement in preventing aluminum-induced neurotoxicity in rats.
Methods−The rats were segregated into four groups, which included normal controls and aluminum-treated, curcumin- treated, and aluminum- and curcumin-treated animals.
Results−Eight weeks of aluminum treatment resulted in a significant increase in the levels of lipid peroxidation (LPO) and reactive oxygen species (ROS) in both cerebellum and cerebrum as compared to normal animals. In contrast, the activities of glutathione-S-transferase (GST), glutathione reductase (GR), superoxide dismutase (SOD), and reduced glutathione (GSH) levels were found to be significantly decreased following aluminum treatment. Furthermore, aluminum resulted in anxiety in rats as determined with the elevated plus maze test. In addition, an appreciable decrease was noticed in both muscular and locomotor activity of aluminum-treated animals, as determined by rotarod and actophotometer tests, respectively. However, in aluminum-treated animals that also received curcumin supplements, the already raised levels of LPO and ROS returned to near normal limits in the cerebrum. Moreover, curcumin treatment of the aluminum-treated animals also resulted in a significant improvement in the levels of GSH and enzyme activities of GST in both the cerebrum and cerebellum. Also, improvement was observed in the behavior of aluminum-treated animals upon curcumin supplementation.
Conclusion−The present study suggests that curcumin may act as a neuroprotectant against aluminum-induced neurodegenerative and behavioral disorders, but further investigations are needed to understand the exact mechanism of neuroprotection.

对本文的引用
  1. Ikram Muhammad Faisal, Farhat Syeda Mehpara, Mahboob Aamra, Baig Saeeda, Yaqinuddin Ahmed, Ahmed Touqeer, Expression of DnMTs and MBDs in AlCl3-Induced Neurotoxicity Mouse Model, Biological Trace Element Research, 199, 9, 2021. Crossref

  2. Dai Chongshan, Xiao Xilong, Zhang Yuan, Xiang Biao, Hoyer Daniel, Shen Jianzhong, Velkov Tony, Tang Shusheng, Curcumin Attenuates Colistin-Induced Peripheral Neurotoxicity in Mice, ACS Infectious Diseases, 6, 4, 2020. Crossref

  3. Cui Yonghua, Che Yi, Wang Hongxin, Bergamot essential oil attenuate aluminum-induced anxiety-like behavior through antioxidation, anti-inflammatory and GABA regulation in rats, Food and Chemical Toxicology, 145, 2020. Crossref

  4. Rahbar Mohammad H., Samms-Vaughan Maureen, Zhao Yuansong, Saroukhani Sepideh, Bressler Jan, Hessabi Manouchehr, Grove Megan L., Shakespeare-Pellington Sydonnie, Loveland Katherine A., Interactions between Environmental Factors and Glutathione S-Transferase (GST) Genes with Respect to Detectable Blood Aluminum Concentrations in Jamaican Children, Genes, 13, 10, 2022. Crossref

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