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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Comparing the Effects of Light- or Sonic-Activated Drug Delivery: Photochemical/Sonochemical Internalization

卷 35, 册 1, 2016, pp. 91-98
DOI: 10.1615/JEnvironPatholToxicolOncol.2016015463
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摘要

Photochemical internalization (PCI) is a technique that uses the photochemical properties of photodynamic therapy (PDT) for the enhanced delivery of endolysosomal-trapped macromolecules into the cell cytoplasm. The released agent can therefore exert its full biological activity, in contrast to being degraded by lysosomal hydrolases. Activation of photosensitizers via ultrasound (US), called sonodynamic therapy (SDT), has been proposed as an alternative to light-activated PDT for the treatment of cancerous tumors. The use of focused US (FUS) to activate photosensitizers allows treatment at tumor sites buried deep within tissues, overcoming one of the main limitations of PDT/PCI. We have examined ultrasonic activation of photosensitizers together with the anticancer agent bleomycin (BLM) using sonochemical internalization (SCI), as an alternative to light-activated PCI. Our results indicate that, compared to drug or US treatment alone, US activation of the photosensitizer AlPcS2a together with BLM significantly inhibits the ability of treated glioma cells to form clonogenic colonies.

对本文的引用
  1. Li Buhong, Zhang Jinde, Emerging strategies for enhanced photodynamic therapy, Asia Communications and Photonics Conference 2016, 2016. Crossref

  2. Hirschberg Henry, Madsen Steen J, Synergistic efficacy of ultrasound, sonosensitizers and chemotherapy: a review, Therapeutic Delivery, 8, 5, 2017. Crossref

  3. Guo Qing-Long, Dai Xing-Liang, Yin Meng-Yuan, Cheng Hong-Wei, Qian Hai-Sheng, Wang Hua, Zhu Dao-Ming, Wang Xian-Wen, Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives, Military Medical Research, 9, 1, 2022. Crossref

  4. Sumi Nanako, Nagahiro Shota, Nakata Eiji, Watanabe Kazunori, Ohtsuki Takashi, Ultrasound-dependent RNAi using TatU1A-rose bengal conjugate, Bioorganic & Medicinal Chemistry Letters, 68, 2022. Crossref

  5. Liu Dongdong, Dai Xingliang, Ye Lei, Wang Hua, Qian Haisheng, Cheng Hongwei, Wang Xianwen, Nanotechnology meets glioblastoma multiforme: Emerging therapeutic strategies, WIREs Nanomedicine and Nanobiotechnology, 2022. Crossref

  6. Hersh Andrew M., Bhimreddy Meghana, Weber-Levine Carly, Jiang Kelly, Alomari Safwan, Theodore Nicholas, Manbachi Amir, Tyler Betty M., Applications of Focused Ultrasound for the Treatment of Glioblastoma: A New Frontier, Cancers, 14, 19, 2022. Crossref

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