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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Genistein Induces Cytochrome P450 1B1 Gene Expression and Cell Proliferation in Human Breast Cancer MCF-7 Cells

卷 34, 册 2, 2015, pp. 153-159
DOI: 10.1615/JEnvironPatholToxicolOncol.2015013315
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摘要

Cytochrome P450 1B1 (CYP1B1) plays an important role in breast cancer development and progression by bioactivating endogenous estrogens and environmental carcinogens. In this study, we examined the effect of the soy isoflavone genistein on CYP1B1 gene expression, reactive oxygen species (ROS) production, and cell proliferation in human breast cancer MCF-7 cells. Real-time reverse transcription polymerase chain reaction (RT-PCR) analysis showed a dose-dependent induction of CYP1B1 gene expression in the cells treated with 5 and 25 μM of genistein. Genistein at 5 μM exhibited a synergistic effect on the CYP1B1 mRNA level induced by the environmental carcinogen 7,12-dimethylbenz[a]anthracene. We also found that genistein at 5 μM increased cellular levels of ROS and stimulated cell proliferation starting from the second day of culture. This study suggests that physiological concentrations of genistein stimulate ROS production and breast cancer cell proliferation through the induction of CYP1B1 gene expression. More extensive studies are warranted to further characterize the role of genistein and the CYP1B1 enzyme in human breast carcinogenesis.

对本文的引用
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  8. Piccolella Margherita, Crippa Valeria, Cristofani Riccardo, Rusmini Paola, Galbiati Mariarita, Cicardi Maria Elena, Meroni Marco, Ferri Nicola, Morelli Federica F., Carra Serena, Messi Elio, Poletti Angelo, The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells, Oncotarget, 8, 6, 2017. Crossref

  9. Lee Yongkyu, Lee Jehyung, Lim Changbaek, Anticancer activity of flavonoids accompanied by redox state modulation and the potential for a chemotherapeutic strategy, Food Science and Biotechnology, 30, 3, 2021. Crossref

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  11. Carrera Alexa N., Grant Marianne K.O., Zordoky Beshay N., CYP1B1 as a therapeutic target in cardio-oncology, Clinical Science, 134, 21, 2020. Crossref

  12. Sharifi-Rad Javad, Quispe Cristina, Imran Muhammad, Rauf Abdur, Nadeem Muhammad, Gondal Tanweer Aslam, Ahmad Bashir, Atif Muhammad, Mubarak Mohammad S., Sytar Oksana, Zhilina Oxana Mihailovna, Garsiya Ekaterina Robertovna, Smeriglio Antonella, Trombetta Domenico, Pons Daniel Gabriel, Martorell Miquel, Cardoso Susana M., Razis Ahmad Faizal Abdull, Sunusi Usman, Kamal Ramla Muhammad, Rotariu Lia Sanda, Butnariu Monica, Docea Anca Oana, Calina Daniela, Toan Sam, Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits, Oxidative Medicine and Cellular Longevity, 2021, 2021. Crossref

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