每年出版 4 期
ISSN 打印: 0731-8898
ISSN 在线: 2162-6537
IF:
2.4
5-Year IF:
2.8
Immediacy Index:
0.5
Eigenfactor:
0.00049
JCI:
0.59
SJR:
0.429
SNIP:
0.507
CiteScore™::
3.9
H-Index:
49
Indexed in
Protective Effects of a By-Product of the Pecan Nut Industry (Carya illinoensis) on the Toxicity Induced by Cyclophosphamide in Rats Carya illinoensis Protects Against Cyclophosphamide- Induced Toxicity
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摘要
This study investigated the antioxidant effects of pecan nut (Carya illinoensis) shell aqueous extract (AE) on toxicity induced by cyclophosphamide (CP) in the heart, kidney, liver, bladder, plasma and erythrocytes of rats. Rats were treated with water or pecan shell AE (5%) ad libitum, replacing drinking water for 37 days up to the end of the experiment. On day 30, half of each group received a single administration of vehicle or CP 200 mg/kg-ip. After 7 days, the organs were removed. Rats treated with CP showed an increase in lipid peroxidation (LP) and decrease in reduced glutathione (GSH) levels in all structures. Catalase (CAT) activity was increased in the heart and decreased in liver and kidney. Besides, CP treatment decreased plasmatic vitamin C (VIT C) levels and induced bladder macroscopical and microscopical damages. In contrast, co-treatment with pecan shell AE prevented the LP development and the GSH depletion in all structures, except in the heart and plasma, respectively. CAT activity in the heart and liver as well as the plasmatic VIT C levels remained unchanged. Finally, AE prevented CP-induced bladder injury. These findings revealed the protective role of pecan shell AE in CP-induced multiple organ toxicity.
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Müller Liz Girardi, Pase Camila Simonetti, Reckziegel Patrícia, Barcelos Raquel C.S., Boufleur Nardeli, Prado Ana Cristina P., Fett Roseane, Block Jane Mara, Pavanato Maria Amália, Bauermann Liliane F., da Rocha João Batista Teixeira, Burger Marilise Escobar, Hepatoprotective effects of pecan nut shells on ethanol-induced liver damage, Experimental and Toxicologic Pathology, 65, 1-2, 2013. Crossref
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Merwid-Ląd A, Trocha M, Chlebda E, Sozański T, Magdalan J, Ksiądzyna D, Kopacz M, Kuźniar A, Nowak D, Pieśniewska M, Fereniec-Gołębiewska L, Kwiatkowska J, Szeląg A, Effects of morin-5′-sulfonic acid sodium salt (NaMSA) on cyclophosphamide-induced changes in oxido-redox state in rat liver and kidney, Human & Experimental Toxicology, 31, 8, 2012. Crossref
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Charles Denys J., Sources of Natural Antioxidants and Their Activities, in Antioxidant Properties of Spices, Herbs and Other Sources, 2012. Crossref
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