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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Antioxidant and Hepatoprotective Effects of Crataegus songarica Methanol Extract

卷 33, 册 2, 2014, pp. 131-143
DOI: 10.1615/JEnvironPatholToxicolOncol.2014010606
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摘要

The protective activity of the methanolic extract of the Crataegus songarica leaves was investigated against CCl4- and paracetamol-induced liver damage. On folklore levels, this plant is popularly used to treat various toxicological diseases. We evaluated both in vitro and ex vivo antioxidant activity of C. songarica. At higher concentration of plant extract (700 µg/ml), 88.106% inhibition on DPPH radical scavenging activity was observed and reducing power of extract was increased in a concentration-dependent manner. We also observed its inhibition on Fe2+/ascorbic acid-induced lipid peroxidation on rat liver microsomes in vitro. In addition, C. songarica extract exhibited antioxidant effects on calf thymus DNA damage induced by Fenton reaction. Hepatotoxicity was induced by challenging the animals with CCl4 (1 ml/kg body weight, i.p.) and paracetamol (500 mg/kg body weight) and the extract was administered at three concentrations (100, 200, and 300 mg/kg body weight). Hepatoprotection was evaluated by determining the activities of liver function marker enzymes and antioxidant status of liver. Administration of CCl4 elevated the levels of liver function enzymes, SGOT, SGPT, and LDH. We also observed a dramatic increase in ALT, AST, bilirubin, and alkaline phosphatase levels in rats administered 500 mg/kg body weight of paracetamol. Decreased antioxidant defense system as glutathione (GSH), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR), glutathione-S-transferase (GST), and superoxide dismutase (SOD) were observed in rats treated with CCl4 and paracetamol. Pretreatment with the extract decreased the elevated serum GOT, GPT, LDH, bilirubin, and alkaline phosphatase activities and increased the antioxidant enzymes in a dose-dependent manner. Therefore, C. songarica methanol extract may be an effective hepatic protective agent and viable candidate for treating hepatic disorders and other oxidative stress-related diseases.

对本文的引用
  1. Coballase-Urrutia Elvia, Cárdenas-Rodríguez Noemí, González-García María Carolina, Núñez-Ramírez Eithan, Floriano-Sánchez Esaú, González-Trujano María Eva, Fernández-Rojas Berenice, Pedraza-Chaverrí José, Montesinos-Correa Hortencia, Rivera-Espinosa Liliana, Sampieri Aristides III, Carmona-Aparicio Liliana, Biochemical and molecular modulation of CCl 4 -induced peripheral and central damage by Tilia americana var. mexicana extracts, Saudi Pharmaceutical Journal, 25, 3, 2017. Crossref

  2. Sarfraz Iqra, Rasul Azhar, Jabeen Farhat, Younis Tahira, Zahoor Muhammad Kashif, Arshad Muhammad, Ali Muhammad, Fraxinus: A Plant with Versatile Pharmacological and Biological Activities, Evidence-Based Complementary and Alternative Medicine, 2017, 2017. Crossref

  3. Serairi-Beji Raja, Aidi Wannes Wissem, Hamdi Amel, Tej Rabeb, Ksouri Riadh, Saidani-Tounsi Moufida, Lachaal Mokhtar, Karray-Bouraoui Najoua, Antioxidant and hepatoprotective effects ofAsparagus albusleaves in carbon tetrachloride-induced liver injury rats, Journal of Food Biochemistry, 42, 1, 2018. Crossref

  4. Zou Liyi, Chen Shaoru, Li Li, Wu Tie, The protective effect of hyperoside on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2, Experimental and Toxicologic Pathology, 69, 7, 2017. Crossref

  5. Anandasadagopan SK, Sundaramoorthy C, Pandurangan AK, Nagarajan V, Srinivasan K, Ganapasam S, S-Allyl cysteine alleviates inflammation by modulating the expression of NF-κB during chromium (VI)-induced hepatotoxicity in rats, Human & Experimental Toxicology, 36, 11, 2017. Crossref

  6. Bulbul Md. Rakibul Hassan, Rahman Md. Atiar, Rahman Md. Zillur, Emran Talha Bin, Afroze Mirola, Khan Mala, Chowdhury Muhammad Abid Hasan, Ibrahim Mohammed Auwal, Chowdhury Mohammed Sohel, Leea macrophylla (Roxb.) root extract reverses CCl4 induced liver injury through upregulation of antioxidative gene expression: a molecular interaction for therapeutic inception, Advances in Traditional Medicine, 20, 1, 2020. Crossref

  7. Younis Waqas, Alamgeer , Schini-Kerth V.B., Brentan da Silva Denise, Junior Arquimedes Gasparotto, Bukhari Ishfaq Ali, Assiri Asaad Mohamed, Role of the NO/cGMP pathway and renin-angiotensin system in the hypotensive and diuretic effects of aqueous soluble fraction from Crataegus songarica K. Koch, Journal of Ethnopharmacology, 249, 2020. Crossref

  8. Cui Xiaoji, Lin Qinlu, Liang Ying, Plant-Derived Antioxidants Protect the Nervous System From Aging by Inhibiting Oxidative Stress, Frontiers in Aging Neuroscience, 12, 2020. Crossref

  9. Tassell Mary C., Keaveney Anne‐Maria, Kingston Rosari, Gilroy Deirdre, Lehane Mary, Lucey Brigid, Furey Ambrose, Synergy in Whole Plant Medicine:Crataegusspp.: An Example, in Herbs, Spices and Medicinal Plants, 2020. Crossref

  10. Malik Khafsa, Ahmad Mushtaq, Öztürk Münir, Altay Volkan, Zafar Muhammad, Sultana Shazia, Medicinal Plants Used for Hypertension, in Herbals of Asia, 2021. Crossref

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