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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Radioprotection of Swiss albino mice by Prunus avium with special reference to hematopoietic system

卷 30, 册 1, 2011, pp. 55-70
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i1.60
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摘要

Prunus avium (family Rosaceae) has been used ethnomedicinally for the treatment of many diseases, but its radioprotective efficacy has hardly been explored. Presence of high anthocyanin content and phenolic compound with good antioxidative capacity has been reported by researchers. Its radioprotective effect against 5, 7, 10 and 12 Gy gamma radiation was evaluated by 30 day survival assay. Regression analysis yielded LD50/30 5.81 and 9.43Gy for irradiated only and PAE + radiation groups, respectively. The Dose Reduction Factor (DRF) was computed as 1.62. For biochemical and hematological studies, Swiss albino mice were divided into four groups: (1) control (vehicle treated); (2) PAE (P. avium fruit extract) treated (450 mg kg/day for 15 consequetive days); (3) irradiated (5 Gy) and (4) PAE + irradiated. The irradiation of animals resulted in a significant elevation of lipid peroxidation and depletion in glutathione and protein levels in blood serum and spleen which could be significantly checked by administration of PAE. Radiation induced deficit in blood sugar, cholesterol and hematological constituents could also be modulated by supplementation of PAE before and after irradiation. The possible prophylactic and therapeutic action noted by P. avium against radiation-induced metabolic disorders may be due to synergistic action of various antioxidants, minerals, vitamins etc. present in the fruit. Further mechanistic studies aimed at identifying the role of major ingredients in the extract are needed.

对本文的引用
  1. Sharma Archana, Sisodia Rashmi, Bhatnagar Deepak, Saxena Virendra Kumar, Spatial memory and learning performance and its relationship to protein synthesis of Swiss albino mice exposed to 10 GHz microwaves, International Journal of Radiation Biology, 90, 1, 2014. Crossref

  2. Lim T. K., Prunus avium, in Edible Medicinal And Non-Medicinal Plants, 2012. Crossref

  3. Haritwal Teena, Tiwari Mrinalini, Agrawala Paban, Herbal Radioprotectors: A mini-review of the Current Status, Natural Resources for Human Health, 2, 2, 2022. Crossref

  4. Shivappa Pooja, Bernhardt GrisildaVidya, Natural radioprotectors on current and future perspectives: A mini-review, Journal of Pharmacy And Bioallied Sciences, 14, 2, 2022. Crossref

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