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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Cell Cycle Regulators Modulating Con A Mitogenesis and Apoptosis in Low-Dose Radiation-Exposed Mice

卷 24, 册 1, 2005, pp. 33-44
DOI: 10.1615/JEnvPathToxOncol.v24.i1.40
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摘要

Low doses of ionizing radiation (LDR) are reported to induce transient changes in mouse lymphocytes, such as enhanced response to polyclonal T cell mitogens, increased expression of heat shock proteins, and p53. We evaluated the role of cell cycle proteins and apoptosis in lymphocytes of C57BL/6 mice exposed to 20 cGy fractionated LDR. We found an enhanced cell proliferation in response to the mitogen concanavalin A (con A). The expression of several cell cycle and apoptosis-related intracellular and extracellular proteins was analyzed by flowcytometry following labeling with specific antibodies. An increased response to con A was accompanied by an increase in the expression of proliferating cell nuclear antigen (PCNA) and cyclins D and A. The expression of cyclin B did not change significantly. In 20 cGy-exposed C57BL/6 mice, the caspase activity and apoptosis were reduced in con A-stimulated spleen cells as compared to sham controls. The expression of Fas and Fas ligand was analyzed by labeling with specific antibodies followed by flowcytometry. There was no change in the expression of Fas and Fas ligand. The change in the mitochondrial transmembrane potential was followed by labeling the cells with the dye 5,5',6,6',-tetrachloro-1,1,3,3-tetraethylbenzimidazolcarbocyanine iodide (JC-I) and analyzing by flowcytometry. Mitochondrial stability was increased in spleen cells of LDR-treated mice. These data suggest that LDR induces augmentation of mitogenic response by modulation of expression of cyclins and the mitochondrial membrane potential leading to reduced apoptosis.

对本文的引用
  1. Pandey Ruchi, Shankar Bhavani S., Sharma Deepak, Sainis Krishna B., Low dose radiation induced immunomodulation: Effect on macrophages and CD8+T cells, International Journal of Radiation Biology, 81, 11, 2005. Crossref

  2. Bogdándi Enikő Noémi, Balogh Andrea, Felgyinszki Nikolett, Szatmári Tünde, Persa Eszter, Hildebrandt Guido, Sáfrány Géza, Lumniczky Katalin, Effects of Low-Dose Radiation on the Immune System of Mice after Total-Body Irradiation, Radiation Research, 174, 4, 2010. Crossref

  3. Hernández-Godoy J., Planelles D., Balsalobre B., González-Molina A., The effect of in vitro γ-irradiation on mitogenic responsiveness of murine lymphocytes, Journal of Physiology and Biochemistry, 64, 3, 2008. Crossref

  4. Rybkina Valentina L., Azizova Tamara V., Scherthan Harry, Meineke Viktor, Doerr Harald, Adamova Galina V., Teplyakova Olga V., Osovets Sergey V., Bannikova Maria V., Zurochka Alexander V., Expression of blood serum proteins and lymphocyte differentiation clusters after chronic occupational exposure to ionizing radiation, Radiation and Environmental Biophysics, 53, 4, 2014. Crossref

  5. Bannister L. A., Serran M. L., Mantha R. R., Low-Dose Gamma Radiation Does Not Induce an Adaptive Response for Micronucleus Induction in Mouse Splenocytes, Radiation Research, 184, 5, 2015. Crossref

  6. Bugden Michelle, Billing Sukhmani, Mak Kei Cheng, Norton Farrah, Klokov Dmitry, Wang Yi, Ionizing radiation affects miRNA composition in both young and old mice, International Journal of Radiation Biology, 95, 10, 2019. Crossref

  7. Kapala Jacek, Karpinska Maria, Mnich Stanislaw, Effective Doses of Ionizing Radiation during Therapeutic Peat Mud Treatment from a Deposit in the Knyszyn Forest (Northeastern Poland), International Journal of Environmental Research and Public Health, 17, 18, 2020. Crossref

  8. Goldberg Zelanna, Rocke David M., Schwietert Chad, Berglund Susanne R., Santana Alison, Jones Angela, Lehmann Jörg, Stern Robin, Lu Ruixiao, Hartmann Siantar Christine, Human In vivo Dose-Response to Controlled, Low-Dose Low Linear Energy Transfer Ionizing Radiation Exposure, Clinical Cancer Research, 12, 12, 2006. Crossref

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