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ISSN 打印: 1040-8401

ISSN 在线: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Role of γδ T Lymphocytes in Immune Response in Humans and Mice

卷 18, 册 4, 1998, pp. 327-357
DOI: 10.1615/CritRevImmunol.v18.i4.30
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摘要

T lymphocytes recognize antigen through the T cell receptor. T cells expressing the γδ T cell receptor have been found in many species. Whereas murine αβ T cells are concentrated in the lymphoid organs, γδ T cells represent only a minor population in the adult thymus and peripheral lymphoid organs (less than 5% of the population). However, murine γδ cells predominate in epidermis, in epithelial layers of small intestine, in lung, and in female reproductive organs. In contrast, human γδ cells predominate in lymphoid organs. Despite extensive progress in the molecular characterization of the γδ T cell receptor and its genes, the physiological role of γδ T cells has remained elusive for many years. It is becoming now clear that, in contrast to αβ cells that recognize peptide/MHC complexes, γδ T cells appear to recognize unprocessed proteic antigens and, in humans, also a class of widely represented nonproteic antigens containing critical phosphate moieties. Similarly, it is now known that γδ cells can perform a vast array of immune effector functions and appear to play important roles in antimicrobial immunity as well as in chronic inflammatory reactions.

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