每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
Indexed in
Inhibitory Receptor-Mediated Regulation of Natural Killer Cells
摘要
Natural killer (NK) cells are capable of directly recognizing pathogens, pathogen-infected cells, and transformed cells. NK cells recognize target cells using approximately 100 germ-line encoded receptors, which display activating or inhibitory function. NK cell activation usually requires the engagement of more than one receptor, and these may contribute distinct signaling inputs that are required for the firm adhesion of NK cells to target cells, polarization, and the release of cytotoxic granules, as well as the production of cytokines. In this article we discuss receptor-mediated mechanisms that counteract NK cell activation. The distinct intracellular inhibitory signaling pathways and how they can dominantly interfere with NK cell activation signaling events are discussed first. In addition, mechanisms by which inhibitory receptors modulate cellular activation at the level of receptor−ligand interactions are described. Receptor-mediated inhibition of NK cell function serves three main purposes: ensuring tolerance of NK cells to normal cells, enabling NK cell responses to aberrant host cells that have lost an inhibitory ligand, and, finally, allowing the recognition of certain pathogens that do not express inhibitory ligands.
-
Liu Pingyi, Chen Lingling, Zhang Haiyan, Natural Killer Cells in Liver Disease and Hepatocellular Carcinoma and the NK Cell-Based Immunotherapy, Journal of Immunology Research, 2018, 2018. Crossref
-
Han Chen, Jiang Yongjie, Wang Zhaoxia, Wang Hengxiao, Natural killer cells involved in tumour immune escape of hepatocellular carcinomar, International Immunopharmacology, 73, 2019. Crossref
-
Binder Gwendolyn K., Amado Rafael G., T Cell Receptor Engineered T Cell Therapy in Oncology, in Second Generation Cell and Gene-based Therapies, 2020. Crossref
-
Sheng Lixia, Mu Qitian, Wu Xiaoqing, Yang Shujun, Zhu Huiling, Wang Jiaping, Lai Yanli, Wu Hao, Sun Ye, Hu Yongxian, Fu Huarui, Wang Yi, Xu Kaihong, Sun Yongcheng, Zhang Yanli, Zhang Ping, Zhou Miao, Lai Binbin, Xu Zhijuan, Gao Minjie, Zhang Yi, Ouyang Guifang, Cytotoxicity of Donor Natural Killer Cells to Allo-Reactive T Cells Are Related With Acute Graft-vs.-Host-Disease Following Allogeneic Stem Cell Transplantation, Frontiers in Immunology, 11, 2020. Crossref