每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
Indexed in
Induction of Th17 Cellular Immunity With a Novel Nanoemulsion Adjuvant
摘要
T17 (T-helper-17) cytokine responses have been recently recognized as an important component for the protective immunity produced by vaccination. However, the mechanism by which immune adjuvants induce T17 immunity has not been defined. We have developed a novel mucosal nanoemulsion (NE) adjuvant that produces a robust humoral and T1 cellular immunity. Herein, we demonstrate that immunization with NE adjuvant induces a T17 response to diverse antigens in both outbred and inbred mice. CD86 deficiency had a limited effect on the induction of IL-17, however, double CD80/CD86, CD40, and IL-6 (interleukin 6) mutant mice failed to produce T17 immunity in response to NE adjuvant. Mice deficient in TLR2 and TLR4 (Toll-like receptors 2 and 4) had a diminished IL-17 response. Our data indicate that nasal mucosal immunization with NE adjuvant produces T1 and T17 immunity; that this process requires IL-6, CD40, and at least one of the CD80/CD86 molecules; and that the induction of TH17 is enhanced by the presence of TLR2 and TLR4 receptors. This unique approach to vaccination may have a significant role in protection against mucosal and intracellular pathogens.
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Dey Antu K, Srivastava Indresh K, Novel adjuvants and delivery systems for enhancing immune responses induced by immunogens, Expert Review of Vaccines, 10, 2, 2011. Crossref
-
Makidon Paul E., Belyakov Igor M., Blanco Luz P., Janczak Katarzyna W., Landers Jeffrey, Bielinska Anna U., Groom Jeffrey V., Baker James R., Nanoemulsion mucosal adjuvant uniquely activates cytokine production by nasal ciliated epithelium and induces dendritic cell trafficking, European Journal of Immunology, 42, 8, 2012. Crossref
-
Myc Andrzej, Kukowska-Latallo Jolanta F., Smith Douglas M., Passmore Crystal, Pham Tiffany, Wong Pamela, Bielinska Anna U., Baker James R., Nanoemulsion nasal adjuvant W805EC induces dendritic cell engulfment of antigen-primed epithelial cells, Vaccine, 31, 7, 2013. Crossref
-
Smith Douglas M., Simon Jakub K., Baker Jr James R., Applications of nanotechnology for immunology, Nature Reviews Immunology, 13, 8, 2013. Crossref
-
Gopal Radha, Rangel-Moreno Javier, Fallert Junecko Beth A., Mallon Daniel J., Chen Kong, Pociask Derek A., Connell Terry D., Reinhart Todd A., Alcorn John F., Ross Ted M., Kolls Jay K., Khader Shabaana A., Mucosal Pre-Exposure to Th17-Inducing Adjuvants Exacerbates Pathology after Influenza Infection, The American Journal of Pathology, 184, 1, 2014. Crossref
-
Passmore Crystal, Makidon Paul E, O’Konek Jessica J, Zahn Joseph A, Pannu Jessie, Hamouda Tarek, Bitko Vira, Myc Andrzej, Lukacs Nicolas W, Fattom Ali, Baker Jr James R, Intranasal immunization with W805EC adjuvanted recombinant RSV rF-ptn enhances clearance of respiratory syncytial virus in a mouse model, Human Vaccines & Immunotherapeutics, 10, 3, 2014. Crossref
-
Kumar Pawan, Chen Kong, Kolls Jay K, Th17 cell based vaccines in mucosal immunity, Current Opinion in Immunology, 25, 3, 2013. Crossref
-
Gopal R, Rangel-Moreno J, Slight S, Lin Y, Nawar H F, Fallert Junecko B A, Reinhart T A, Kolls J, Randall T D, Connell T D, Khader S A, Interleukin-17-dependent CXCL13 mediates mucosal vaccine–induced immunity against tuberculosis, Mucosal Immunology, 6, 5, 2013. Crossref
-
Tupin Emmanuel, Fourth International Conference: Modern Vaccines/Adjuvants Formulation—Impact On Future Development, Human Vaccines & Immunotherapeutics, 9, 9, 2013. Crossref
-
Bergmann-Leitner Elke, Leitner Wolfgang, Adjuvants in the Driver’s Seat: How Magnitude, Type, Fine Specificity and Longevity of Immune Responses Are Driven by Distinct Classes of Immune Potentiators, Vaccines, 2, 2, 2014. Crossref
-
O'Konek Jessica J, Makidon Paul E, Landers Jeffrey J, Cao Zhengyi, Malinczak Carrie-Anne, Pannu Jessie, Sun Jennifer, Bitko Vira, Ciotti Susan, Hamouda Tarek, Wojcinski Zbigniew W, Lukacs Nicholas W, Fattom Ali, Baker James R, Intranasal nanoemulsion-based inactivated respiratory syncytial virus vaccines protect against viral challenge in cotton rats, Human Vaccines & Immunotherapeutics, 11, 12, 2015. Crossref
-
Jesus Sandra, Borges Olga, Recent Developments in the Nasal Immunization against Anthrax, World Journal of Vaccines, 01, 03, 2011. Crossref
-
Orzechowska Beata U., Kukowska-Latallo Jolanta F., Coulter Alexa D., Szabo Zsuzsanna, Gamian Andrzej, Myc Andrzej, Nanoemulsion-based mucosal adjuvant induces apoptosis in human epithelial cells, Vaccine, 33, 19, 2015. Crossref
-
Stanberry L.R., Simon J.K., Johnson C., Robinson P.L., Morry J., Flack M.R., Gracon S., Myc A., Hamouda T., Baker J.R., Safety and immunogenicity of a novel nanoemulsion mucosal adjuvant W805EC combined with approved seasonal influenza antigens, Vaccine, 30, 2, 2012. Crossref
-
Lawson Louise B, Norton Elizabeth B, Clements John D, Defending the mucosa: adjuvant and carrier formulations for mucosal immunity, Current Opinion in Immunology, 23, 3, 2011. Crossref
-
Fan Yongyi, Guo Rui, Shi Xiangyang, Allen Steven, Cao Zhengyi, Baker James, Wang Su, Modified Nanoemulsions with Iron Oxide for Magnetic Resonance Imaging, Nanomaterials, 6, 12, 2016. Crossref
-
Bielinska Anna U., O’Konek Jessica J., Janczak Katarzyna W., Baker James R., Immunomodulation of TH2 biased immunity with mucosal administration of nanoemulsion adjuvant, Vaccine, 34, 34, 2016. Crossref
-
Ahmed Mushtaq, Smith Douglas M., Hamouda Tarek, Rangel-Moreno Javier, Fattom Ali, Khader Shabaana A., A novel nanoemulsion vaccine induces mucosal Interleukin-17 responses and confers protection upon Mycobacterium tuberculosis challenge in mice, Vaccine, 35, 37, 2017. Crossref
-
Wong Pamela T., Leroueil Pascale R., Smith Douglas M., Ciotti Susan, Bielinska Anna U., Janczak Katarzyna W., Mullen Catherine H., Groom Jeffrey V., Taylor Erin M., Passmore Crystal, Makidon Paul E., O’Konek Jessica J., Myc Andrzej, Hamouda Tarek, Baker James R., Renukaradhya Gourapura J, Formulation, High Throughput In Vitro Screening and In Vivo Functional Characterization of Nanoemulsion-Based Intranasal Vaccine Adjuvants, PLOS ONE, 10, 5, 2015. Crossref
-
Huang Lu, Hinchman Meleana, Mendez Susana, McDowell Mary Ann, Coinjection with TLR2 Agonist Pam3CSK4 Reduces the Pathology of Leishmanization in Mice, PLOS Neglected Tropical Diseases, 9, 3, 2015. Crossref
-
Toda Tsuguto, Yoshino Shin, Enhancement of ovalbumin-specific Th1, Th2, and Th17 immune responses by amorphous silica nanoparticles, International Journal of Immunopathology and Pharmacology, 29, 3, 2016. Crossref
-
Pathak Kamla, Pattnaik Satyanarayan, Swain Kalpana, Application of Nanoemulsions in Drug Delivery, in Nanoemulsions, 2018. Crossref
-
Qin Juan, Li Li, Jin Qian, Guo Dan, Liu Miao, Fan Chenling, Li Jing, Shan Zhongyan, Teng Weiping, Estrogen receptor β activation stimulates the development of experimental autoimmune thyroiditis through up-regulation of Th17-type responses, Clinical Immunology, 190, 2018. Crossref
-
Chuang Yu-Min, Pinn Michael L., Karakousis Petros C., Hung Chien-Fu, Intranasal Immunization with DnaK Protein Induces Protective Mucosal Immunity against Tuberculosis in CD4-Depleted Mice, Frontiers in Cellular and Infection Microbiology, 8, 2018. Crossref
-
O'Konek Jessica J., Landers Jeffrey J., Janczak Katarzyna W., Goel Rishi R., Mondrusov Anna M., Wong Pamela T., Baker James R., Nanoemulsion adjuvant–driven redirection of TH2 immunity inhibits allergic reactions in murine models of peanut allergy, Journal of Allergy and Clinical Immunology, 141, 6, 2018. Crossref
-
Smith Douglas, Streatfield Stephen J., Acosta Hugo, Ganesan Shyamala, Fattom Ali, A nanoemulsion-adjuvanted intranasal H5N1 influenza vaccine protects ferrets against homologous and heterologous H5N1 lethal challenge, Vaccine, 37, 42, 2019. Crossref
-
Guan Minglong, Ma Hengli, Fan Xiaoyun, Chen Xu, Miao Manli, Wu Huimei, Dexamethasone alleviate allergic airway inflammation in mice by inhibiting the activation of NLRP3 inflammasome, International Immunopharmacology, 78, 2020. Crossref
-
Bielinska Anna U., Makidon Paul E., Janczak Katarzyna W., Blanco Luz P., Swanson Benjamin, Smith Douglas M., Pham Tiffany, Szabo Zsuzsanna, Kukowska-Latallo Jolanta F., Baker James R., Distinct Pathways of Humoral and Cellular Immunity Induced with the Mucosal Administration of a Nanoemulsion Adjuvant, The Journal of Immunology, 192, 6, 2014. Crossref
-
Stewart , Triccas , Petrovsky , Adjuvant Strategies for More Effective Tuberculosis Vaccine Immunity, Microorganisms, 7, 8, 2019. Crossref
-
Calzas Cynthia, Chevalier Christophe, Innovative Mucosal Vaccine Formulations Against Influenza A Virus Infections, Frontiers in Immunology, 10, 2019. Crossref
-
Hamouda Tarek, Simon Jakub, Fattom Ali, Baker James, NanoBio™ Nanoemulsion for Mucosal Vaccine Delivery, in Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines, 2013. Crossref
-
Campuzano Althea, Zhang Hao, Ostroff Gary R., dos Santos Dias Lucas, Wüthrich Marcel, Klein Bruce S., Yu Jieh-Juen, Lara Humberto H., Lopez-Ribot Jose L., Hung Chiung-Yu, CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection, The Journal of Immunology, 204, 12, 2020. Crossref
-
Zenobia Camille, Herpoldt Karla-Luise, Freire Marcelo, Is the oral microbiome a source to enhance mucosal immunity against infectious diseases?, npj Vaccines, 6, 1, 2021. Crossref
-
Wong Pamela T., Wang Su He, Ciotti Susan, Makidon Paul E., Smith Douglas M., Fan Yongyi, Schuler Charles F., Baker James R., Formulation and Characterization of Nanoemulsion Intranasal Adjuvants: Effects of Surfactant Composition on Mucoadhesion and Immunogenicity, Molecular Pharmaceutics, 11, 2, 2014. Crossref
-
Wang Su He, Fan Yongyi, Makidon Paul E, Cao Zhengyi, Baker James R, Induction of immune tolerance in mice with a novel mucosal nanoemulsion adjuvant and self-antigen, Nanomedicine, 7, 6, 2012. Crossref
-
Wong Pamela T., Goff Peter H., Sun Rachel J., Ruge Matthew J., Ermler Megan E., Sebring Alyssa, O’Konek Jessica J., Landers Jeffrey J., Janczak Katarzyna W., Sun Weina, Baker James R., Combined Intranasal Nanoemulsion and RIG-I Activating RNA Adjuvants Enhance Mucosal, Humoral, and Cellular Immunity to Influenza Virus, Molecular Pharmaceutics, 18, 2, 2021. Crossref
-
Farazuddin Mohammad, Landers Jeffrey J., Janczak Katarzyna W., Lindsey Hayley K., Finkelman Fred D., Baker James R., O’Konek Jessica J., Mucosal Nanoemulsion Allergy Vaccine Suppresses Alarmin Expression and Induces Bystander Suppression of Reactivity to Multiple Food Allergens, Frontiers in Immunology, 12, 2021. Crossref
-
Ralbovsky Nicole M., Soukup Randal J., Lomont Justin P., Lauro Mackenzie L., Gulasarian Amanda, Saha-Shah Anumita, Winters Michael A., Richardson Douglas D., Wang Sheng-Ching, Mangion Ian, Smith Joseph P., In situ real time monitoring of emulsification and homogenization processes for vaccine adjuvants, The Analyst, 147, 3, 2022. Crossref
-
Li Pengfei, Wang Jingkang, Wang Chunguo, Cheng Long, Ma Quantao, Li Yaqi, An Yongcheng, Dai Hongyu, Duan Yuhui, Wang Tieshan, Ma Xuan, Zhang Minghui, Wang Ting, Zhao Baosheng, Therapeutic effects and mechanisms study of Hanchuan Zupa Granule in a Guinea pig model of cough variant asthma, Journal of Ethnopharmacology, 269, 2021. Crossref
-
Menter David G., Patterson Sherri L., Logsdon Craig D., Kopetz Scott, Sood Anil K., Hawk Ernest T., Convergence of Nanotechnology and Cancer Prevention: Are We There Yet?, Cancer Prevention Research, 7, 10, 2014. Crossref
-
Rai Aishwarya, Mitra Anik, Chatterjee Niranjan, Kumar Piyush, Malik Sujata, Kumar Vivek, Misra Santosh K., Biomaterials for Advanced Personalized Therapeutic Approaches, in Encyclopedia of Materials: Plastics and Polymers, 2022. Crossref
-
Zohar Tomer, Hsiao Jeff C., Mehta Nickita, Das Jishnu, Devadhasan Anush, Karpinski Wiktor, Callahan Cheryl, Citron Michael P., DiStefano Daniel J., Touch Sinoeun, Wen Zhiyun, Sachs Jeffrey R., Cejas Pedro J., Espeseth Amy S., Lauffenburger Douglas A., Bett Andrew J., Alter Galit, Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates, Cell Host & Microbe, 30, 1, 2022. Crossref