每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
Indexed in
Genes for Control of Spread of the Tumor and Mycobacterium tuberculosis Infection in the Mouse
摘要
In this review, new data are interpreted that provide some answers to the question of why the immune system fails to respond to metastatic cancers. A function such as an element of the immune response is expected to be under the control of a gene. To find a gene, a mutant is required. Complex screens have been designed and used to detect mouse mutants resisting spread of transplantable tumors (in a spontaneous metastasis assay). Curiously, both mutants with increased and decreased resistance to spread of the tumor have been found. S-27 is a strongly resistant mutant linked to MHC; this mutation also affected some responses to Mycobacterium tuberculosis infection. A long sought link between malignant transformation and vaccination against mycobacterial diseases is discovered in this mutant. A search for a molecule responsible for effects of the S-27 mutation resulted in an unexpected finding. The S-27 mutant carries complex nucleotide alterations at the junction between the signal sequence and the sequences coding for the mature MHC class II Aβ polypeptide chain. Antigen recognition region of the Aβ molecule is not affected by this mutation. Some concepts developed during the course of this study are illustrated in Figures 1 to 4.
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van der Weyden Louise, Adams David J., Using mice to unveil the genetics of cancer resistance, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1826, 2, 2012. Crossref
-
Newman Mark J., Truax Robert E., French Dennis D., Dietrich Marilyn A., Franke Donald, Stear Michael J., Evidence for genetic control of vaccine-induced antibody responses in cattle, Veterinary Immunology and Immunopathology, 50, 1-2, 1996. Crossref
-
Liu Yinong, McMinimy Douglas L., Savinov Alexei Y., Johnson Kevin A., Kremlev Sergey G., Chapoval Andrei I., Egorov Igor K., Hidden variables: unstable Aβ chain genes encoding antigen recognition structures in tumor survivors, Molecular Immunology, 37, 18, 2000. Crossref