每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
Indexed in
Regulatory T-cell Trafficking: From Thymic Development to Tumor-Induced Immune Suppression
摘要
Regulatory T cells (Tregs) have become a priority for many investigators in immunology due to their potent immunosuppressive and tolerogenic effects. While Treg activity is required for normal immune homeostasis, dysregulation of their numbers can induce autoimmunity or aid in the pathogenesis of disease. Therefore, great effort has been made to understand the mechanisms by which Tregs accumulate in different areas of the body. Like other lymphocytes, Tregs migrate in response to a network of chemotactic stimuli involving chemokines, chemokine receptors, integrins, and their corresponding ligands. However, many of these stimuli are exclusive to Tregs, inducing their migration while leaving conventional populations unaffected. It is these selective stimuli that result in increased ratios of Tregs among conventional effector populations, leading to changes in immune suppression and homeostasis. This review explores selective Treg trafficking during thymic Treg development, migration to secondary lymphoid tissues and emigration into the periphery during homeostatic conditions, inflammation, and the tumor microenvironment, placing emphasis on stimuli that selectively recruits Tregs to target locations.
-
Savage Peter A., Malchow Sven, Leventhal Daniel S., Basic principles of tumor-associated regulatory T cell biology, Trends in Immunology, 34, 1, 2013. Crossref
-
Ghosh Shomir, Lobera Mercedes, Sundrud Mark S., , 46, 2011. Crossref
-
Yang Pengyuan, Li Qi-Jing, Feng Yuxiong, Zhang Yun, Markowitz Geoffrey J., Ning Shanglei, Deng Yuezhen, Zhao Jiangsha, Jiang Shan, Yuan Yunfei, Wang Hong-Yang, Cheng Shu-Qun, Xie Dong, Wang Xiao-Fan, TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma, Cancer Cell, 22, 3, 2012. Crossref
-
Melve Guro Kristin, Ersvær Elisabeth, Kittang Astrid Olsnes, Bruserud Øystein, The chemokine system in allogeneic stem-cell transplantation: a possible therapeutic target?, Expert Review of Hematology, 4, 5, 2011. Crossref
-
Huen Ngar-Yee, Pang Alan Lap-Yin, Tucker Jo A., Lee Tin-Lap, Vergati Matteo, Jochems Caroline, Intrivici Chiara, Cereda Vittore, Chan Wai-Yee, Rennert Owen M., Madan Ravi A., Gulley James L., Schlom Jeffrey, Tsang Kwong Y., Up-regulation of proliferative and migratory genes in regulatory T cells from patients with metastatic castration-resistant prostate cancer, International Journal of Cancer, 133, 2, 2013. Crossref
-
Ng Sheung P., Silverstone Allen E., Lai Zhi-Wei, Zelikoff Judith T., Prenatal Exposure to Cigarette Smoke Alters Later-Life Antitumor Cytotoxic T-Lymphocyte (CTL) Activity Via Possible Changes in T-Regulatory Cells, Journal of Toxicology and Environmental Health, Part A, 76, 19, 2013. Crossref
-
Mattiussi Claudio, Can an Engineer Fix an Immune System?–Rethinking theoretical biology, Acta Biotheoretica, 61, 2, 2013. Crossref
-
Chaudhary Belal, Abd Al Samid May, al-Ramadi Basel K, Elkord Eyad, Phenotypic alterations, clinical impact and therapeutic potential of regulatory T cells in cancer, Expert Opinion on Biological Therapy, 14, 7, 2014. Crossref
-
Geng Yiting, Wang Hui, Lu Changqing, Li Qing, Xu Bin, Jiang Jingting, Wu Changping, Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significance, International Journal of Clinical Oncology, 20, 2, 2015. Crossref
-
Pozo-Balado María Mar, Martínez-Bonet Marta, Rosado Isaac, Ruiz-Mateos Ezequiel, Méndez-Lagares Gema, Rodríguez-Méndez María Mar, Vidal Francisco, Muñoz-Fernández María Angeles, Pacheco Yolanda María, Leal Manuel, Maraviroc Reduces the Regulatory T-Cell Frequency in Antiretroviral-Naive HIV-Infected Subjects, The Journal of Infectious Diseases, 210, 6, 2014. Crossref
-
Mrizak Dhafer, Martin Nathalie, Barjon Clément, Jimenez-Pailhes Anne-Sophie, Mustapha Rami, Niki Toshiro, Guigay Joël, Pancré Véronique, de Launoit Yvan, Busson Pierre, Moralès Olivier, Delhem Nadira, Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells, JNCI: Journal of the National Cancer Institute, 107, 1, 2015. Crossref
-
Halvorsen Elizabeth C., Mahmoud Sahar M., Bennewith Kevin L., Emerging roles of regulatory T cells in tumour progression and metastasis, Cancer and Metastasis Reviews, 33, 4, 2014. Crossref
-
Mattei Fabrizio, Schiavoni Giovanna, Sestili Paola, Spadaro Francesca, Fragale Alessandra, Sistigu Antonella, Lucarini Valeria, Spada Massimo, Sanchez Massimo, Scala Stefania, Battistini Angela, Belardelli Filippo, Gabriele Lucia, IRF-8 Controls Melanoma Progression by Regulating the Cross Talk between Cancer and Immune Cells within the Tumor Microenvironment, Neoplasia, 14, 12, 2012. Crossref
-
Liu Chang, Workman Creg J., Vignali Dario A. A., Targeting regulatory T cells in tumors, The FEBS Journal, 283, 14, 2016. Crossref
-
Chaudhary Belal, Elkord Eyad, Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting, Vaccines, 4, 3, 2016. Crossref
-
Peng Dong-Jun, Liu Rebecca, Zou Weiping, Regulatory T Cells in Human Ovarian Cancer, Journal of Oncology, 2012, 2012. Crossref
-
Ehirchiou Driss, Muller Yannick D., Chicheportiche Rachel, Heyrani Nobari Ruhollah, Madelon Natacha, Schneider Mårten K.J., Seebach Jörg D., Chemoattractant Signals and Adhesion Molecules Promoting Human Regulatory T Cell Recruitment to Porcine Endothelium, Transplantation, 100, 4, 2016. Crossref
-
HUANG CHENGLIN, ZHOU LEI, CHANG XIAOHAN, PANG XIAOAO, ZHANG HUIJIE, ZHANG SHULAN, B7-H3, B7-H4, Foxp3 and IL-2 expression in cervical cancer: Associations with patient outcome and clinical significance, Oncology Reports, 35, 4, 2016. Crossref
-
Ugor Emese, Prenek Lilla, Pap Ramóna, Berta Gergely, Ernszt Dávid, Najbauer József, Németh Péter, Boldizsár Ferenc, Berki Tímea, Glucocorticoid hormone treatment enhances the cytokine production of regulatory T cells by upregulation of Foxp3 expression, Immunobiology, 223, 4-5, 2018. Crossref
-
Chellappa Stalin, Aandahl Einar M., Taskén Kjetil, Cancer Immunity and Immune Evasion Mechanisms, in Biomarkers of the Tumor Microenvironment, 2017. Crossref
-
Tashireva L. A., Perelmuter V. M., Manskikh V. N., Denisov E. V., Savelieva O. E., Kaygorodova E. V., Zavyalova M. V., Types of immune-inflammatory responses as a reflection of cell–cell interactions under conditions of tissue regeneration and tumor growth, Biochemistry (Moscow), 82, 5, 2017. Crossref
-
Tselios Konstantinos, Sarantopoulos Alexandros, Gkougkourelas Ioannis, Boura Panagiota, T Regulatory Cells in Systemic Lupus Erythematosus: Current Knowledge and Future Prospects, in Lupus, 2017. Crossref
-
Lee Gap Ryol, Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells, Mediators of Inflammation, 2017, 2017. Crossref
-
Dwarakanath Bilikere S., Farooque Abdullah, Gupta Seema, Targeting regulatory T cells for improving cancer therapy: Challenges and prospects, Cancer Reports, 1, 1, 2018. Crossref
-
Barros Nicolas, Vasquez Nestor, Woll Fernando, Sanchez Cesar, Valencia Braulio, Llanos-Cuentas Alejandro, White Jr. A. Clinton, Montes Martin, Regulatory T-Cell Dynamics in Cutaneous and Mucocutaneous Leishmaniasis due to Leishmania braziliensis , The American Journal of Tropical Medicine and Hygiene, 98, 3, 2018. Crossref
-
Wang Cong, Yang Yan, Gao Sujun, Chen Jingcheng, Yu Jinyuan, Zhang Han, Li Mingxi, Zhan Xingying, Li Wei, Immune dysregulation in myelodysplastic syndrome: Clinical features, pathogenesis and therapeutic strategies, Critical Reviews in Oncology/Hematology, 122, 2018. Crossref
-
Nelson Alexander, Cunha Christina, Nishimura Michael I., Iwashima Makio, Activated human Foxp3+ regulatory T cells produce membrane-bound TNF, Cytokine, 111, 2018. Crossref
-
Li Xiaoxiao, Ma Kai, Song Shanai, Shen Fangzhen, Kuang Tao, Zhu Yingqian, Liu Zimin, Tight correlation between FoxM1 and FoxP3+ Tregs in gastric cancer and their clinical significance, Clinical and Experimental Medicine, 18, 3, 2018. Crossref
-
Ahmed Mona M., Ibrahim Hanaa M., Balata Safa A., Abdou Ahmed M., Expression of immunomodulator programmed death ligand 1 and fork head box protein 3 in squamous cell carcinoma of cervix, Egyptian Journal of Pathology, 38, 1, 2018. Crossref
-
Kazakov O. V., Kabakov A. V., Poveshchenko A. F., Raiter T. V., Strunkin D. N., Poveshchenko O. V., Lykov A. P., Konenkov V. I., Effect of Neoadjuvant and Adjuvant Therapy of Experimental Breast Cancer on the Structure of Mesenteric Lymph Nodes, Bulletin of Experimental Biology and Medicine, 166, 2, 2018. Crossref
-
Trabanelli Sara, Očadlíková Darina, Gulinelli Sara, Curti Antonio, Salvestrini Valentina, de Paula Vieira Rodolfo, Idzko Marco, Di Virgilio Francesco, Ferrari Davide, Lemoli Roberto M., Extracellular ATP Exerts Opposite Effects on Activated and Regulatory CD4+T Cells via Purinergic P2 Receptor Activation, The Journal of Immunology, 189, 3, 2012. Crossref
-
Najafi Soheil, Mirshafiey Abbas, The role of T helper 17 and regulatory T cells in tumor microenvironment, Immunopharmacology and Immunotoxicology, 41, 1, 2019. Crossref
-
Ellison Amy R, Savage Anna E, DiRenzo Grace V, Langhammer Penny, Lips Karen R, Zamudio Kelly R, Fighting a Losing Battle: Vigorous Immune Response Countered by Pathogen Suppression of Host Defenses in the Chytridiomycosis-Susceptible Frog Atelopus zeteki , G3 Genes|Genomes|Genetics, 4, 7, 2014. Crossref
-
TAMADA Koji, Development of Novel Anti-Cancer Immunotherapy Targeting Immune Evasion Mechanisms, Yamaguchi Medical Journal, 61, 1+2, 2012. Crossref
-
D’Silva Selma, B. Rajadhyaksha Sunil, Singh Meenakshi, Immune Dysregulation in MDS: The Role of Cytokines and Immune Cells, in Recent Developments in Myelodysplastic Syndromes, 2019. Crossref
-
Adah Dickson, Yang Yijun, Liu Quan, Gadidasu Kranthi, Tao Zhu, Yu Songlin, Dai Linglin, Li Xiaofen, Zhao Siting, Qin Limei, Qin Li, Chen Xiaoping, Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer model, Cell Communication and Signaling, 17, 1, 2019. Crossref
-
Wang Jing-Jing, Siu Michelle Kwan-Yee, Jiang Yu-Xin, Chan David Wai, Cheung Annie Nga-Yin, Ngan Hextan Yuen-Sheung, Chan Karen Kar-Loen, Infiltration of T cells promotes the metastasis of ovarian cancer cells via the modulation of metastasis-related genes and PD-L1 expression, Cancer Immunology, Immunotherapy, 69, 11, 2020. Crossref
-
Ma Kai, Li Xiaoxiao, Lv Jing, Liu Zimin, Zhang Lijian, Cong Hui, Wang Huiyun, Shen Fangzhen, Yue Lu, Correlations between CD4 + FoxP3 + Treg and expression of FoxM1 and Ki‐67 in gastric cancer patients , Asia-Pacific Journal of Clinical Oncology, 17, 2, 2021. Crossref
-
Yu Su Jong, Greten Tim F., Deciphering and Reversing Immunosuppressive Cells in the Treatment of Hepatocellular Carcinoma, Journal of Liver Cancer, 20, 1, 2020. Crossref
-
Iida Kota , Miyake Makito , Onishi Kenta , Hori Shunta , Morizawa Yosuke , Gotoh Daisuke , Itami Yoshitaka , Onishi Sayuri , Nakai Yasushi , Anai Satoshi , Tanaka Nobumichi , Fujimoto Kiyohide , Prognostic impact of tumor‑infiltrating CD276/Foxp3‑positive lymphocytes and associated circulating cytokines in patients undergoing radical nephrectomy for localized renal cell carcinoma, Oncology Letters, 2019. Crossref
-
Saito Makoto , Senjo Hajime , Kanaya Minoru , Izumiyama Koh , Mori Akio , Tanaka Masanori , Morioka Masanobu , Miyashita Kencho , Ishida Yusuke , Late duodenal metastasis from renal cell carcinoma with newly developed malignant lymphoma: A case report, Molecular and Clinical Oncology, 2018. Crossref
-
Lisovska Natalya , Shanazarov Nasrulla , Tumor progression mechanisms: Insights from the central immune regulation of tissue homeostasis (Review), Oncology Letters, 2019. Crossref
-
Holbrook Beth C., Alexander-Miller Martha A., Higher Frequency and Increased Expression of Molecules Associated with Suppression on T Regulatory Cells from Newborn Compared with Adult Nonhuman Primates, The Journal of Immunology, 205, 8, 2020. Crossref
-
Dadey Rebekah E., Workman Creg J., Vignali Dario A. A., Regulatory T Cells in the Tumor Microenvironment, in Tumor Microenvironment, 1273, 2020. Crossref
-
Priceman Saul J., Shen Shudan, Wang Lin, Deng Jiehui, Yue Chanyu, Kujawski Maciej, Yu Hua, S1PR1 Is Crucial for Accumulation of Regulatory T Cells in Tumors via STAT3, Cell Reports, 6, 6, 2014. Crossref
-
Su Liang, Jiang Yiming, Xu Yu, Li Xinye, Gao Wenbin, Xu Chunwei, Zeng Changqian, Song Jie, Weng Wencai, Liang Wenbo, Xihuang pill promotes apoptosis of Treg cells in the tumor microenvironment in 4T1 mouse breast cancer by upregulating MEKK1/SEK1/JNK1/AP-1 pathway, Biomedicine & Pharmacotherapy, 102, 2018. Crossref
-
Melese Etienne S., Franks Elizabeth, Cederberg Rachel A., Harbourne Bryant T., Shi Rocky, Wadsworth Brennan J., Collier Jenna L., Halvorsen Elizabeth C., Johnson Fraser, Luu Jennifer, Oh Min Hee, Lam Vivian, Krystal Gerald, Hoover Shelley B., Raffeld Mark, Simpson R. Mark, Unni Arun M., Lam Wan L., Lam Stephen, Abraham Ninan, Bennewith Kevin L., Lockwood William W., CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development, OncoImmunology, 11, 1, 2022. Crossref
-
Ajina Adam, Maher John, Synergistic combination of oncolytic virotherapy with CAR T-cell therapy, in Cancer Immunotherapy, 164, 2019. Crossref
-
Ben-Yehuda Hila, Arad Michal, Peralta Ramos Javier María, Sharon Efrat, Castellani Giulia, Ferrera Shir, Cahalon Liora, Colaiuta Sarah Phoebeluc, Salame Tomer-Meir, Schwartz Michal, Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy, Molecular Neurodegeneration, 16, 1, 2021. Crossref
-
Wang Juan, Zhou Pan, Han Yunwei, Zhang Hongwei, Platelet transfusion for cancer secondary thrombocytopenia: Platelet and cancer cell interaction, Translational Oncology, 14, 4, 2021. Crossref
-
Galustian Christine, Dasgupta Prokar, Regulatory T Cells , in eLS, 2016. Crossref
-
Sarkar Tania, Dhar Subhanki, Sa Gaurisankar, Tumor-infiltrating T-regulatory cells adapt to altered metabolism to promote tumor-immune escape, Current Research in Immunology, 2, 2021. Crossref
-
Gao Yanan, You Maojun, Fu Junliang, Tian Meijie, Zhong Xinyue, Du Chengzhi, Hong Zhixian, Zhu Zhenyu, Liu Junliang, Markowitz Geoffrey J., Wang Fu-Sheng, Yang Pengyuan, Intratumoral stem-like CCR4+ regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B, Journal of Hepatology, 76, 1, 2022. Crossref
-
Hirata Aya, Sawai Eri, Henmi Marina, Shibasaki Chihiro, Mizoguchi Yukihiro, Narumi Kenta, Aoki Kazunori, Imatinib Mesylate Exerted Antitumor Effect by Promoting Infiltration of Effector T Cells in Tumor, Biological and Pharmaceutical Bulletin, 45, 1, 2022. Crossref
-
Enokida Tomohiro, Nishikawa Hiroyoshi, Regulatory T cells, as a target in anticancer immunotherapy, Immunotherapy, 9, 8, 2017. Crossref
-
Lv Mingming, Xu Yujun, Tang Ruijing, Ren Jing, Shen Sunan, Chen Yueqiu, Liu Baorui, Hou Yayi, Wang Tingting, miR141–CXCL1–CXCR2 Signaling–Induced Treg Recruitment Regulates Metastases and Survival of Non–Small Cell Lung Cancer, Molecular Cancer Therapeutics, 13, 12, 2014. Crossref
-
Wolach Ofir, Stone Richard, Autoimmunity and Inflammation in Myelodysplastic Syndromes, Acta Haematologica, 136, 2, 2016. Crossref
-
Sarkar Tania, Dhar Subhanki, Chakraborty Dwaipayan, Pati Subhadip, Bose Sayantan, Panda Abir K., Basak Udit, Chakraborty Sourio, Mukherjee Sumon, Guin Aharna, Jana Kuladip, Sarkar Diptendra K., Sa Gaurisankar, FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer, Frontiers in Immunology, 13, 2022. Crossref
-
Barakos Georgios Petros, Hatzimichael Eleftheria, Microenvironmental Features Driving Immune Evasion in Myelodysplastic Syndromes and Acute Myeloid Leukemia, Diseases, 10, 2, 2022. Crossref
-
Son Jimin, Cho Jae-Won, Park Hyo Jin, Moon Jihyun, Park Seyeon, Lee Hoyoung, Lee Jeewon, Kim Gamin, Park Su-Myeong, Lira Sergio A., Mckenzie Andrew N., Kim Hye Young, Choi Cheol Yong, Lim Yong Taik, Park Seong Yong, Kim Hye Ryun, Park Su-Hyung, Shin Eui-Cheol, Lee Insuk, Ha Sang-Jun, Tumor-Infiltrating Regulatory T-cell Accumulation in the Tumor Microenvironment Is Mediated by IL33/ST2 Signaling, Cancer Immunology Research, 8, 11, 2020. Crossref
-
Xue Chen, Gu Xinyu, Bao Zhengyi, Su Yuanshuai, Lu Juan, Li Lanjuan, The Mechanism Underlying the ncRNA Dysregulation Pattern in Hepatocellular Carcinoma and Its Tumor Microenvironment, Frontiers in Immunology, 13, 2022. Crossref
-
Lisovska Natalya, Multilevel mechanism of immune checkpoint inhibitor action in solid tumors: History, present issues and future development (Review), Oncology Letters, 23, 6, 2022. Crossref
-
Kos Kevin, Salvagno Camilla, Wellenstein Max D., Aslam Muhammad A., Meijer Denize A., Hau Cheei-Sing, Vrijland Kim, Kaldenbach Daphne, Raeven Elisabeth A.M., Schmittnaegel Martina, Ries Carola H., de Visser Karin E., Tumor-associated macrophages promote intratumoral conversion of conventional CD4+ T cells into regulatory T cells via PD-1 signalling, OncoImmunology, 11, 1, 2022. Crossref
-
Kushekhar Kushi, Chellappa Stalin, Aandahl Einar M., Taskén Kjetil, Role of Lymphocytes in Cancer Immunity and Immune Evasion Mechanisms, in Biomarkers of the Tumor Microenvironment, 2022. Crossref
-
Batista-Duharte Alexander, Téllez-Martínez Damiana, Fuentes Deivys Leandro Portuondo, Carlos Iracilda Zeppone, Molecular adjuvants that modulate regulatory T cell function in vaccination: A critical appraisal, Pharmacological Research, 129, 2018. Crossref
-
Zhang Mengyan, Shi Ran, Guo Zhongying, He Jingdong, Cancer-associated fibroblasts promote cell growth by activating ERK5/PD-L1 signaling axis in colorectal cancer, Pathology - Research and Practice, 216, 4, 2020. Crossref
-
Han Qin, Wang Mengchen, Dong Xi, Wei Fei, Luo Yun, Sun Xiaobo, Non-coding RNAs in hepatocellular carcinoma: Insights into regulatory mechanisms, clinical significance, and therapeutic potential, Frontiers in Immunology, 13, 2022. Crossref
-
Ma Kai, Sun Zhaowei, Li Xueliang, Guo Jingyun, Wang Qinlei, Teng Mujian, Forkhead box M1 recruits FoxP3 + Treg cells to induce immune escape in hilar cholangiocarcinoma , Immunity, Inflammation and Disease, 10, 11, 2022. Crossref