每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
Indexed in
Innate Recognition of Bacteria: Engagement of Multiple Receptors
摘要
Until recently, consensus was that the mechanism of action of the innate immune system was a simplified one. Current research findings in the field of innate recognition of bacteria suggest that it involves complex associations of receptors depending on cell type and bacterial stimuli, CD14, integrins, Toll-like receptors (TLRs), CD55, ion channels, and activation clusters containing heat shock proteins, chemokine receptor 4 and a plethora of other molecules have been shown to serve as key molecules in bacterial recognition. In this article, we review all the advances in the field and discuss the possibility that the repertoire for recognition of pathogens is defined by the combinational engagement of multiple receptors.
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Wang Min, Hajishengallis George, Lipid raft-dependent uptake, signalling and intracellular fate ofPorphyromonas gingivalisin mouse macrophages, Cellular Microbiology, 10, 10, 2008. Crossref
-
Lebeer Sarah, Vanderleyden Jos, De Keersmaecker Sigrid C. J., Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens, Nature Reviews Microbiology, 8, 3, 2010. Crossref
-
Hajishengallis George, Toll gates to periodontal host modulation and vaccine therapy, Periodontology 2000, 51, 1, 2009. Crossref
-
Pope Michael R., Hoffman Sara M., Tomlinson Stephen, Fleming Sherry D., Complement regulates TLR4-mediated inflammatory responses during intestinal ischemia reperfusion, Molecular Immunology, 48, 1-3, 2010. Crossref
-
Dai Qun, Zhang Jun, Pruett Stephen B., Ethanol alters cellular activation and CD14 partitioning in lipid rafts, Biochemical and Biophysical Research Communications, 332, 1, 2005. Crossref
-
Tichelaar Jay W., Wesselkamper Scott C., Chowdhury Supurna, Yin Hulian, Berclaz Pierre-Yves, Sartor Maureen A., Leikauf George D., Whitsett Jeffrey A., DURATION-DEPENDENT CYTOPROTECTIVE VERSUS INFLAMMATORY EFFECTS OF LUNG EPITHELIAL FIBROBLAST GROWTH FACTOR-7 EXPRESSION, Experimental Lung Research, 33, 8-9, 2007. Crossref
-
Reinhart Konrad, Glück Thomas, Ligtenberg Jack, Tschaikowsky Klaus, Bruining Albert, Bakker Jan, Opal Steven, Moldawer Lyle L., Axtelle Tim, Turner Terence, Souza Sonia, Pribble John, CD14 receptor occupancy in severe sepsis: Results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14)*, Critical Care Medicine, 32, 5, 2004. Crossref
-
Simard Alain R., Rivest Serge, Do pathogen exposure and innate immunity cause brain diseases?, Neurological Research, 27, 7, 2005. Crossref
-
Weber-Stadlbauer U, Epigenetic and transgenerational mechanisms in infection-mediated neurodevelopmental disorders, Translational Psychiatry, 7, 5, 2017. Crossref
-
Zhang Xueqing, Kluger Yuval, Nakayama Yasuhiro, Poddar Ranjana, Whitney Constance, DeTora Adam, Weissman Sherman M., Newburger Peter E., Gene expression in mature neutrophils: early responses to inflammatory stimuli, Journal of Leukocyte Biology, 75, 2, 2004. Crossref
-
van Bergenhenegouwen Jeroen, Plantinga Theo S., Joosten Leo A. B., Netea Mihai G., Folkerts Gert, Kraneveld Aletta D., Garssen Johan, Vos Arjan P., TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors, Journal of Leukocyte Biology, 94, 5, 2013. Crossref
-
Triantafilou Kathy, Triantafilou Martha, Cell Surface Stress Proteins and the Receptor for Lipopolysaccharide, in Moonlighting Cell Stress Proteins in Microbial Infections, 7, 2013. Crossref
-
Hajishengallis George, Krauss Jennifer L., Liang Shuang, McIntosh Megan L., Lambris John D., Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity, in Current Topics in Innate Immunity II, 946, 2012. Crossref
-
Schromm Andra B., Howe Jörg, Ulmer Artur J., Wiesmüller Karl-Heinz, Seyberth Tobias, Jung Günther, Rössle Manfred, Koch Michel H.J., Gutsmann Thomas, Brandenburg Klaus, Physicochemical and Biological Analysis of Synthetic Bacterial Lipopeptides, Journal of Biological Chemistry, 282, 15, 2007. Crossref
-
TRIANTAFILOU Martha, BRANDENBURG Klaus, KUSUMOTO Shoichi, FUKASE Koichi, MACKIE Alan, SEYDEL Ulrich, TRIANTAFILOU Kathy, Combinational clustering of receptors following stimulation by bacterial products determines lipopolysaccharide responses, Biochemical Journal, 381, 2, 2004. Crossref
-
Hajishengallis George, Wang Min, Liang Shuang, Triantafilou Martha, Triantafilou Kathy, Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function, Proceedings of the National Academy of Sciences, 105, 36, 2008. Crossref
-
Fessler Michael B., Arndt Patrick G., Frasch S. Courtney, Lieber Jonathan G., Johnson Christopher A., Murphy Robert C., Nick Jerry A., Bratton Donna L., Malcolm Kenneth C., Worthen G. Scott, Lipid Rafts Regulate Lipopolysaccharide-induced Activation of Cdc42 and Inflammatory Functions of the Human Neutrophil, Journal of Biological Chemistry, 279, 38, 2004. Crossref
-
Hajishengallis George, Ratti Pukar, Harokopakis Evlambia, Peptide Mapping of Bacterial Fimbrial Epitopes Interacting with Pattern Recognition Receptors, Journal of Biological Chemistry, 280, 47, 2005. Crossref