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ISSN 打印: 1040-8401

ISSN 在线: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Structure of IL-10 and Its Role in Autoimmune Exocrinopathy

卷 20, 册 2, 2000, 13 pages
DOI: 10.1615/CritRevImmunol.v20.i2.40
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摘要

Cytokines are implicated in the pathogenesis of a variety of autoimmune disorders. Whether the presence of cytokines is primary or secondary and the extent to which these factors may contribute to the development and progression of clinicopathologic alterations in these disorders remain largely unknown but are highly important questions. Our research focuses on evaluating these issues by using a transgenic approach to direct the constitutive expression of cytokines to epithelial cells in the intact exocrine glands of mice. Our recent studies have focused on the potential of the regulatory cytokine IL-10 produced by type 2 T-helper cells to inhibit inflammation and the development of autoimmue diseases. Using targeted introduction of this molecule into the exocrine gland epithelial cells, we found that IL-10 induced apoptosis of glandular tissues destruction and lymphocyte infiltration consisting primarily of Fas-ligand+ CD4+ T cells, as well as in vitro upregulation of FasL expression on T cells. These results suggest that IL-10 is necessary and sufficient for exocrine gland dysfunction in the transgenic mice. This article discusses recent advances in IL-10 and its role in the pathological conditions of autoimmune exocrinopathy.

对本文的引用
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  2. Haddad John J, Fahlman Christian S, Redox- and oxidant-mediated regulation of interleukin-10: an anti-inflammatory, antioxidant cytokine?, Biochemical and Biophysical Research Communications, 297, 2, 2002. Crossref

  3. Gerli Roberto, Lunardi Claudio, Vinante Fabrizio, Bistoni Onelia, Pizzolo Giovanni, Pitzalis Costantino, Role of CD30+ T cells in rheumatoid arthritis: a counter-regulatory paradigm for Th1-driven diseases, Trends in Immunology, 22, 2, 2001. Crossref

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  5. Haddad John J, Saadé Nayef E, Safieh-Garabedian Bared, Interleukin-10 and the regulation of mitogen-activated protein kinases: are these signalling modules targets for the anti-inflammatory action of this cytokine?, Cellular Signalling, 15, 3, 2003. Crossref

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  8. Huang Eric Y, Madireddi Malavi T, Gopalkrishnan Rahul V, Leszczyniecka Magdalena, Su Zao-zhong, Lebedeva Irina V, Kang Dong-chul, Jiang Hongping, Lin Jiao Jiao, Alexandre Deborah, Chen Yinming, Vozhilla Nicollaq, Mei Mei Xin, Christiansen Keith A, Sivo Frank, Goldstein Neil I, Mhashilkar Abner B, Chada Sunil, Huberman Eliezer, Pestka Sidney, Fisher Paul B, Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties, Oncogene, 20, 48, 2001. Crossref

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