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ISSN 打印: 0743-4863

ISSN 在线: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

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Nanostructured Lipid Carriers: A New Paradigm in Topical Delivery for Dermal and Transdermal Applications

卷 34, 册 4, 2017, pp. 355-386
DOI: 10.1615/CritRevTherDrugCarrierSyst.2017019047
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摘要

Topical drug delivery offers many advantages over oral delivery, such as avoidance of first-pass metabolism, targeting of the active ingredients for a local effect, and patient compliance. However, the achievement of dermal and transdermal delivery needs to conciliate difficulties in permeation across skin barrier at different levels (skin surface, epidermis, dermis, and hypodermis). Nanostructured lipid carriers (NLCs) are recently invented second-generation lipidic carriers. The present article intends to provide an insight of composition, production, and application of these carriers in topical delivery for local and systemic effects. We also discuss key considerations for standardization and critical scale-up issues. In the last decade, the volume of work on NLCs is reflected in various research reports including patents on the development of NLCs, which gives a deeper insight of this emerging field of innovation. These carriers have significance because of their uniqueness to facilitate the interactions at interfaces with the barrier membranes. NLCs are truly a "nanosafe" carrier due to their biodegradable composition and have immense promise to overcome the challenges of dermal and transdermal delivery.

对本文的引用
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