每年出版 4 期
ISSN 打印: 0893-9675
ISSN 在线: 2162-6448
Indexed in
Molecular Mechanisms of Apoptosis in Prostate Cancer
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摘要
Prostate cancer is the most frequently diagnosed noncutaneous cancer in men in Western countries. As in the normal prostate, the initial stages of prostate cancer progression depend on androgens that increase proliferation and inhibit apoptosis. Androgen-deprivation therapy is the major course of treatment in recurrent and metastatic prostate cancer. However, in most cases prostate cancer progresses to an apoptosis-resistant androgen-independent stage for which there is no available therapy. It is therefore important to understand the molecular mechanisms underlying prostate cancer progression, and how prostate cancer cells evade apoptotic mechanisms that give rise to their uncontrolled growth behavior. Here, we have reviewed the most important signaling pathways implicated in prostate cancer apoptosis and cell growth and how they may be deregulated during prostate cancer progression.
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Lygirou Vasiliki, Fasoulakis Konstantinos, Stroggilos Rafael, Makridakis Manousos, Latosinska Agnieszka, Frantzi Maria, Katafigiotis Ioannis, Alamanis Christos, Stravodimos Konstantinos G., Constantinides Constantinos A., Vlahou Antonia, Zoidakis Jerome, Proteomic Analysis of Prostate Cancer FFPE Samples Reveals Markers of Disease Progression and Aggressiveness, Cancers, 14, 15, 2022. Crossref