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ISSN 打印: 0893-9675

ISSN 在线: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Structural and Expression Changes of Septins in Myeloid Neoplasia

卷 15, 册 1-2, 2009, pp. 91-115
DOI: 10.1615/CritRevOncog.v15.i1-2.40
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摘要

Septins are an evolutionarily conserved family of GTP-binding proteins that associate with cellular membranes and the actin and microtubule cytoskeletons. Fourteen septin genes have been characterized to date (SEPT1 to SEPT14) in humans. Septins have been reported to be misregulated in various human diseases, including neurological disorders, infection, and neoplasia. In this review, we describe what is known thus far about septin deregulation in myeloid neoplasia. Septin abnormalities in myeloid neoplasia can be divided into two major groups. First, some septins (SEPT2, SEPT5, SEPT6, SEPT9, and SEPT11) have been repeatedly identified as in-frame fusion partners of the MLL gene in de novo and therapy-related myeloid neoplasia, in both children and adults. Second, deregulation of the expression of septin family genes in hematological cancers can be observed either with or without the concomitant presence of MLL gene fusions. Although current hypotheses regarding the roles of septins in oncogenesis remain speculative for the most part, the fundamental roles of septins in cytokinesis, membrane remodeling, and compartmentalization can provide some clues on how abnormalities in the septin cytoskeleton could be involved in neo-plastic disorders.

对本文的引用
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  2. Xu Feifan, Sun Wei, Li Pan, Chen Jinling, Zhu Dandan, Sun Xiaolei, Wang Jianxin, Feng Jinrong, Song Ke, Duan Yinong, Roemer Klaus, Specificity Protein 1 Transcription Factor Regulates Human ARTS Promoter Activity through Multiple Binding Sites, PLOS ONE, 10, 3, 2015. Crossref

  3. Zou Duobing, Chen Ying, Wu Ningning, Zhang Yi, Ouyang Guifang, Mu Qitian, MLL-SEPT5 Fusion Transcript in Myelodysplastic Syndrome Patient With t(11;22)(q23;q11), Frontiers in Medicine, 8, 2021. Crossref

  4. Anker Jonathan F., Gladfelter Amy S., Axl2 Integrates Polarity Establishment, Maintenance, and Environmental Stress Response in the Filamentous Fungus Ashbya gossypii, Eukaryotic Cell, 10, 12, 2011. Crossref

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