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ISSN 打印: 0893-9675

ISSN 在线: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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The Role of Myb Proteins in Normal and Neoplastic Cell Proliferation

卷 5, 册 4, 1994, pp. 373-388
DOI: 10.1615/CritRevOncog.v5.i4.30
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摘要

The c-myb protooncogene is the prototype of a gene family that contains two other recently described members, A-myb and B-myb. The c-myb gene encodes a transcription regulatory protein, c-Myb, that has distinct DNA-binding domain structure and binding specificity compared with unrelated transcription factors. All three members of the myb protein family, however, display a high degree of homology within their DNA-binding domain, suggesting that they may regulate transcription of a similar set of target genes. We examine here whether, by implication, the individual members of the myb gene family play analogous roles within the cell, in particular focusing on their potential functions in the control of cell proliferation. Expression of both c-myb and B-myb is subject to regulation in the cell cycle, transcripts of these genes being induced within the G1 phase of the cell cycle and persisting at maximal levels through S phase. Consistent with this timing of expression, inhibition of c-Myb and B-Myb synthesis by treatment of cells with anti-sense oligonucleotides indicates that both proteins are required for transition from the G1 to S phase of the cell cycle. The c-Myb and B-Myb proteins cannot be considered as analogs, however, as they show certain differences in trans-activation activity of their target genes. Moreover, while superficially similar, expression of c-myb and B-myb is not coordinated, and it is conceivable that their products have quite distinct functions in the regulation of cell proliferation. The ubiquitous expression of B-myb in cycling cells and its strict regulation during late G1 suggest a universal function for B-Myb in G1 to S phase transition. Consistent with this conclusion, B-myb transcription is controlled by the transcription factor E2F, which has been implicated in cell cycle regulation of a number of genes involved in DNA synthesis. The restricted tissue tropism of c-myb expression and its regulation by certain growth factors such as IL-2 suggest a specific function in transduction of extrinsic proliferation (and differentiation) signals. The role of A-myb in the cell remains to be determined; however, its expression shows no correlation with cell cycling, implying that it has no direct role in cell proliferation. Recent data show that the necessity for c-myb function in proliferation of a number of cell types provides a promising opportunity for intervention in the treatment of certain tumors.

对本文的引用
  1. Bein Kiflai, Husain Mansoor, Ware J. Anthony, Mucenski Michael L., Rosenberg Robert D., Simons Michael, c-Myb function in fibroblasts, Journal of Cellular Physiology, 173, 3, 1997. Crossref

  2. Lyon Jonathan J., Watson Roger J., Conditional inhibition of erythroid differentiation by c-Myb/oestrogen receptor fusion proteins, Differentiation, 59, 3, 1995. Crossref

  3. Kushner David M., Silverman Robert H., Antisense cancer therapy: The state of the science, Current Oncology Reports, 2, 1, 2000. Crossref

  4. Galderisi Umberto, Cipollaro M, Cascino A, Clinical trials of a new class of therapeutic agents: antisense oligonucleotides, Emerging Drugs, 6, 1, 2001. Crossref

  5. Maruyama Hiroshi, Ishitsuka Yosuke, Fujisawa Yasuhiro, Furuta Junichi, Sekido Mitsuru, Kawachi Yasuhiro, B-Myb enhances proliferation and suppresses differentiation of keratinocytes in three-dimensional cell culture, Archives of Dermatological Research, 306, 4, 2014. Crossref

  6. Poorebrahi M., Hoseinzade A.H., Omidi M., Asghari M., Sanadgol N., Isolation and Characterization of CPRgene Promoter from Artemisia annua by Thermal Asymmetric Interlaced Polymerase Chain Reaction (TAIL-PCR), American Journal of Biochemistry and Molecular Biology, 3, 4, 2013. Crossref

  7. Gewirtz Alan M., Oligonucleotide Therapeutics for Human Leukaemia, in Ciba Foundation Symposium 209 - Oligonucleotides as Therapeutic Agents, 2007. Crossref

  8. Saville Mark K., Watson Roger J., , 72, 1997. Crossref

  9. Rushton John J., Ness Scott A., The Conserved DNA Binding Domain Mediates Similar Regulatory Interactions for A-Myb, B-Myb, and c-Myb Transcription Factors, Blood Cells, Molecules, and Diseases, 27, 2, 2001. Crossref

  10. de Vos Sven, Krug Utz, Hofmann Wolf-Karsten, Pinkus Geraldine S., Swerdlow Steven H., Wachsman William, Grogan Thomas M., Said Jonathan W., Koeffler H. Phillip, Cell Cycle Alterations in the Blastoid Variant of Mantle Cell Lymphoma (MCL-BV) as Detected by Gene Expression Profiling of Mantle Cell Lymphoma (MCL) and MCL-BV, Diagnostic Molecular Pathology, 12, 1, 2003. Crossref

  11. Scaria George S., Ramsay Gary, Katzen Alisa L., Two components of the Myb complex, DMyb and Mip130, are specifically associated with euchromatin and degraded during prometaphase throughout development, Mechanisms of Development, 125, 7, 2008. Crossref

  12. Martin Cathie, Paz-Ares Javier, MYB transcription factors in plants, Trends in Genetics, 13, 2, 1997. Crossref

  13. Lyon Jonathan J., Watson Roger J., Interference of Myb transactivation activity by a conditional dominant negative protein: functional interference in a cytotoxic T-cell line results in G1 arrest, Gene, 182, 1-2, 1996. Crossref

  14. Jackson Jean, Ramsay Gary, Sharkov Nikolai V, Lium Eric, Katzen Alisa L, The Role of Transcriptional Activation in the Function of the Drosophila myb Gene, Blood Cells, Molecules, and Diseases, 27, 2, 2001. Crossref

  15. Matalová Eva, Buchtová Marcela, Tucker Abigail S., Bender Timothy P., Janečková Eva, Lungová Vlasta, Balková Simona, Šmarda Jan, Expression and characterization of c-Myb in prenatal odontogenesis, Development, Growth & Differentiation, 53, 6, 2011. Crossref

  16. Nakano Ichiro , Paucar Andres A. , Bajpai Ruchi , Dougherty Joseph D. , Zewail Amani , Kelly Theresa K. , Kim Kevin J. , Ou Jing , Groszer Matthias , Imura Tetsuya , Freije William A. , Nelson Stanley F. , Sofroniew Michael V. , Wu Hong , Liu Xin , Terskikh Alexey V. , Geschwind Daniel H. , Kornblum Harley I. , Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation , Journal of Cell Biology, 170, 3, 2005. Crossref

  17. Rodriguez-Melendez Rocio, Zempleni Janos, Regulation of gene expression by biotin☆ (review), The Journal of Nutritional Biochemistry, 14, 12, 2003. Crossref

  18. Lee Yu-Jin, Kang Yeong-Rim, Lee So Young, Jin Yena, Han Dong Cho, Kwon Byoung-Mog, Ginkgetin induces G2-phase arrest in HCT116 colon cancer cells through the modulation of b-Myb and miRNA34a expression, International Journal of Oncology, 51, 4, 2017. Crossref

  19. Jazaeri Amir A., Lu Karen, Schmandt Rosemarie, Harris Charles P., Rao Pulivarthi H., Sotiriou Christos, Chandramouli G. V. R., Gershenson David M., Liu Edison T., Molecular determinants of tumor differentiation in papillary serous ovarian carcinoma, Molecular Carcinogenesis, 36, 2, 2003. Crossref

  20. Schütz L.F., Hurst R.E., Schreiber N.B., Spicer L.J., Transcriptome profiling of bovine ovarian theca cells treated with fibroblast growth factor 9, Domestic Animal Endocrinology, 63, 2018. Crossref

  21. Sardet Claude, LeCam Laurent, Fabbrizio Eric, Vidal Marc, E2Fs and the Retinoblastoma Protein Family, in Oncogenes as Transcriptional Regulators, 1997. Crossref

  22. Gewirtz Alan M., The c-myb proto-oncogene: a novel target for human gene therapy, in Molecular Genetics and Therapy of Leukemia, 84, 1996. Crossref

  23. Hegde Shrikanth P., Zhao JingFeng, Ashmun Richard A., Shapiro Linda H., c-Maf Induces Monocytic Differentiation and Apoptosis in Bipotent Myeloid Progenitors, Blood, 94, 5, 1999. Crossref

  24. Gewirtz A. M., Oligonucleotide Therapeutics for Human Leukemia, in Gene Therapy, 1998. Crossref

  25. Hegde Shrikanth P., Zhao JingFeng, Ashmun Richard A., Shapiro Linda H., c-Maf Induces Monocytic Differentiation and Apoptosis in Bipotent Myeloid Progenitors, Blood, 94, 5, 1999. Crossref

  26. Arsura Marcello, Hofmann Claudia S., Golay Josee, Introna Martino, Sonenshein Gail E., A-myb rescues murine B-cell lymphomas from IgM-receptor–mediated apoptosis through c-myctranscriptional regulation, Blood, 96, 3, 2000. Crossref

  27. Gewirtz A. M., The c-myb Protooncogene: A Novel Target for Human Gene Therapy, in Gene Therapy, 1999. Crossref

  28. Gewirtz A. M., Nucleic Acid Therapeutics for Human Leukemia: Development and Early Clinical Experience with Oligodeoxynucleotides Directed at c-myb, in Antisense Research and Application, 131, 1998. Crossref

  29. Powzaniuk Mark A., Trotta Rossana, Loza Matthew J., Harth Amy, Iozzo Renato V., Eisenlohr Lawrence C., Perussia Bice, Calabretta Bruno, B-Myb Overexpression Results in Activation and Increased Fas/Fas Ligand-Mediated Cytotoxicity of T and NK Cells, The Journal of Immunology, 167, 1, 2001. Crossref

  30. Ratajczak M. Z., Gewirtz A. M., Oligonucleotide therapeutics for human leukemia, in Molecular Aspects of Cancer and its Therapy, 1998. Crossref

  31. Martin Cara M., Astbury Katharine, Kehoe Louise, O’Crowley Jacqueline Barry, O’Toole Sharon, O’Leary John J., The Use of MYBL2 as a Novel Candidate Biomarker of Cervical Cancer, in Cervical Cancer, 1249, 2015. Crossref

  32. Kronenwett R., Haas R., Specific bcr-abl-Directed Antisense Nucleic Acids and Ribozymes: A Tool for the Treatment of Chronic Myelogenous Leukemia?, in Advances in Hematopoietic Stem Cell Transplantation and Molecular Therapy, 144, 1998. Crossref

  33. Arsura Marcello, Hofmann Claudia S., Golay Josee, Introna Martino, Sonenshein Gail E., A-myb rescues murine B-cell lymphomas from IgM-receptor–mediated apoptosis through c-myctranscriptional regulation, Blood, 96, 3, 2000. Crossref

  34. Bret Caroline, Klein Bernard, Moreaux Jérôme, Gene expression-based risk score in diffuse large B-cell lymphoma, Oncotarget, 3, 12, 2012. Crossref

  35. Sala Arturo, Casella Ida, Bellon Teresa, Calabretta Bruno, Watson Roger J., Peschle Cesare, B-myb Promotes S Phase and Is a Downstream Target of the Negative Regulator p107 in Human Cells , Journal of Biological Chemistry, 271, 16, 1996. Crossref

  36. Gewirtz Alan M, Myb targeted therapeutics for the treatment of human malignancies, Oncogene, 18, 19, 1999. Crossref

  37. Sala Arturo, Kundu Mondira, Casella Ida, Engelhard Andrew, Calabretta Bruno, Grasso Luigi, Paggi Marco G., Giordano Antonio, Watson Roger J., Khalili Kamel, Peschle Cesare, Activation of human B-MYB by cyclins, Proceedings of the National Academy of Sciences, 94, 2, 1997. Crossref

  38. Katzen Alisa L., Bishop J. Michael, myb provides an essential function during Drosophila  development , Proceedings of the National Academy of Sciences, 93, 24, 1996. Crossref

  39. Sala Arturo, Saitta Biagio, De Luca Pasquale, Cervellera Maria N, Casella Ida, Lewis Robert E, Watson Roger, Peschle Cesare, B-MYB transactivates its own promoter through SP1-binding sites, Oncogene, 18, 6, 1999. Crossref

  40. Zorbas Michelle, Sicurella Catherine, Bertoncello Ivan, Venter Deon, Ellis Sarah, Mucenski Michael L, Ramsay Robert G, c-Myb is critical for murine colon development, Oncogene, 18, 42, 1999. Crossref

  41. Oh Il-Hoan, Reddy E. Premkumar, The C-Terminal Domain of B-Myb Acts As a Positive Regulator of Transcription and Modulates Its Biological Functions, Molecular and Cellular Biology, 18, 1, 1998. Crossref

  42. Ess Kevin C, Witte David P, Bascomb Charles P, Aronow Bruce J, Diverse developing mouse lineages exhibit high-level c-Myb expression in immature cells and loss of expression upon differentiation, Oncogene, 18, 4, 1999. Crossref

  43. Oh Il-Hoan, Reddy E Premkumar, The myb gene family in cell growth, differentiation and apoptosis, Oncogene, 18, 19, 1999. Crossref

  44. Corradini Francesca, Cesi Vincenzo, Bartella Viviana, Pani Elisabetta, Bussolari Rita, Candini Olivia, Calabretta Bruno, Enhanced Proliferative Potential of Hematopoietic Cells Expressing Degradation-resistant c-Myb Mutants, Journal of Biological Chemistry, 280, 34, 2005. Crossref

  45. De Falco Giulia, Bagella Luigi, Claudio Pier Paolo, De Luca Antonio, Fu Yan, Calabretta Bruno, Sala Arturo, Giordano Antonio, Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation, Oncogene, 19, 3, 2000. Crossref

  46. Russo Giuseppe, Claudio Pier Paolo, Fu Yan, Stiegler Peter, Yu Zailin, Macaluso Marcella, Giordano Antonio, pRB2/p130 target genes in non-small lung cancer cells identified by microarray analysis, Oncogene, 22, 44, 2003. Crossref

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