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ISSN 打印: 0893-9675

ISSN 在线: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies

卷 20, 册 3-4, 2015, pp. 173-197
DOI: 10.1615/CritRevOncog.2015013713
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摘要

Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life. Unfortunately, clinical outcomes for osteosarcoma patients have not substantially improved in over 30 years. This stagnation in therapeutic advances is perhaps explained by the genetic, epigenetic, and biological complexities of this rare tumor. In this review we provide a general background on the biology of osteosarcoma and the clinical status quo. We go on to enumerate the genetic and epigenetic defects identified in osteosarcoma. Finally, we discuss ongoing large-scale studies in the field and potential new therapies that are currently under investigation.

对本文的引用
  1. Rickel Kirby, Fang Fang, Tao Jianning, Molecular genetics of osteosarcoma, Bone, 102, 2017. Crossref

  2. Shaikh Atik, Li Fangfei, Li Min, He Bing, He Xiaojuan, Chen Guofen, Guo Baosheng, Li Defang, Jiang Feng, Dang Lei, Zheng Shaowei, Liang Chao, Liu Jin, Lu Cheng, Liu Biao, Lu Jun, Wang Luyao, Lu Aiping, Zhang Ge, Present Advances and Future Perspectives of Molecular Targeted Therapy for Osteosarcoma, International Journal of Molecular Sciences, 17, 4, 2016. Crossref

  3. Goodwin C. Rory, Abu-Bonsrah Nancy, Bilsky Mark H., Reynolds Jeremy J., Rhines Laurence D., Laufer Ilya, Disch Alexander C., Bozsodi Arpad, Patel Shreyaskumar R., Gokaslan Ziya L., Sciubba Daniel M., Bettegowda Chetan, Clinical Decision Making, Spine, 41, 20, 2016. Crossref

  4. Qi Baochang, Yu Tiecheng, Wang Chengxue, Wang Tiejun, Yao Jihang, Zhang Xiaomeng, Deng Pengfei, Xia Yongning, Junger Wolfgang G., Sun Dahui, Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate, Journal of Experimental & Clinical Cancer Research, 35, 1, 2016. Crossref

  5. Varshney Jyotika, Scott Milcah, Largaespada David, Subramanian Subbaya, Understanding the Osteosarcoma Pathobiology: A Comparative Oncology Approach, Veterinary Sciences, 3, 1, 2016. Crossref

  6. Gnoli Maria, Ponti Francesca, Sangiorgi Luca, Tumor Syndromes That Include Bone Tumors, Surgical Pathology Clinics, 10, 3, 2017. Crossref

  7. Yuan Quan, Yu Honghao, Chen Jianhua, Song Xiaoyu, Sun Li, Knockdown of pyruvate kinase type M2 suppresses tumor survival and invasion in osteosarcoma cells both in vitro and in vivo, Experimental Cell Research, 362, 1, 2018. Crossref

  8. Ji Quanbo, Xu Xiaojie, Li Ling, Goodman Stuart B, Bi Wenzhi, Xu Meng, Xu Yameng, Fan Zhongyi, Maloney William J, Ye Qinong, Wang Yan, miR-216a inhibits osteosarcoma cell proliferation, invasion and metastasis by targeting CDK14, Cell Death & Disease, 8, 10, 2017. Crossref

  9. Ranjan Atul, Iyer Swathi V., Iwakuma Tomoo, Suppressive roles of A3AR and TMIGD3 i1 in osteosarcoma malignancy, Cell Cycle, 16, 10, 2017. Crossref

  10. Cao Yong, Wu Tianding, Li Dongzhe, Hu Jianzhong, Lu Hongbin, MicroRNA-336 directly targets Sox-2 in osteosarcoma to inhibit tumorigenesis, Molecular Medicine Reports, 15, 6, 2017. Crossref

  11. Gamie Zakareya, Kapriniotis Konstantinos, Papanikolaou Dimitra, Haagensen Emma, Da Conceicao Ribeiro Ricardo, Dalgarno Kenneth, Krippner-Heidenreich Anja, Gerrand Craig, Tsiridis Eleftherios, Rankin Kenneth Samora, TNF-related apoptosis-inducing ligand (TRAIL) for bone sarcoma treatment: Pre-clinical and clinical data, Cancer Letters, 409, 2017. Crossref

  12. Yang Minfei, Liu Bing, Jin Libin, Tao Huimin, Yang Zhengming, Estrogen receptor β exhibited anti-tumor effects on osteosarcoma cells by regulating integrin, IAP, NF-kB/BCL-2 and PI3K/Akt signal pathway, Journal of Bone Oncology, 9, 2017. Crossref

  13. Song Xuanhe, Xie Yaoping, Liu Yang, Shao Ming, Yang Weiliang, MicroRNA-492 overexpression exerts suppressive effects on the progression of osteosarcoma by targeting PAK7, International Journal of Molecular Medicine, 40, 3, 2017. Crossref

  14. Lee Boram, Lee Ji Won, Shim Joon Ho, Joung Je-Gun, Yun Jae Won, Bae Joon Seol, Shin Hyun-Tae, Sung Ki Woong, Park Woong-Yang, Clinical Relevance of Genomic Changes in Recurrent Pediatric Solid Tumors, Translational Oncology, 11, 6, 2018. Crossref

  15. Hattinger Claudia Maria, Patrizio Maria Pia, Tavanti Elisa, Luppi Silvia, Magagnoli Federica, Picci Piero, Serra Massimo, Genetic testing for high-grade osteosarcoma: a guide for future tailored treatments?, Expert Review of Molecular Diagnostics, 18, 11, 2018. Crossref

  16. Michou Laëtitia, Épigénétique des maladies osseuses, Revue du Rhumatisme, 85, 5, 2018. Crossref

  17. Cheng Dong-Dong, Li Shi-Jie, Zhu Bin, Yuan Ting, Yang Qing-Cheng, Fan Cun-Yi, Downregulation of BZW2 inhibits osteosarcoma cell growth by inactivating the Akt/mTOR signaling pathway, Oncology Reports, 38, 4, 2017. Crossref

  18. Du Meng, Wang Yongfeng, Zhao Wei, Wang Zhiquan, Yuan Jie, Bai Hongying, Study on the relationship between livin expression and osteosarcoma, Journal of Bone Oncology, 12, 2018. Crossref

  19. Armstrong Amy E., Walterhouse David O., Leavey Patrick J., Reichek Jennifer, Walz Amy L., Prolonged response to sorafenib in a patient with refractory metastatic osteosarcoma and a somatic PDGFRA D846V mutation, Pediatric Blood & Cancer, 66, 1, 2019. Crossref

  20. Ferracini Riccardo, Martínez Herreros Isabel, Russo Antonio, Casalini Tommaso, Rossi Filippo, Perale Giuseppe, Scaffolds as Structural Tools for Bone-Targeted Drug Delivery, Pharmaceutics, 10, 3, 2018. Crossref

  21. Monterde-Cruz Lucero, Ramírez-Salazar Eric G., Rico-Martínez Genaro, Linares-González Luis M., Guzmán-González Roberto, Delgado-Cedillo Ernesto, Estrada-Villaseñor Eréndira, Valdés-Flores Margarita, Velázquez-Cruz Rafael, Hidalgo-Bravo Alberto, Circulating miR-215-5p and miR-642a-5p as potential biomarker for diagnosis of osteosarcoma in Mexican population, Human Cell, 31, 4, 2018. Crossref

  22. Xiao Tao, Zhou You, Li Hui, Xiong Liang, Wang Jing, Wang Zhi‐Hua, Liu Li‐Hong, MiR‐125b suppresses the carcinogenesis of osteosarcoma cells via the MAPK‐STAT3 pathway, Journal of Cellular Biochemistry, 120, 2, 2019. Crossref

  23. Michou Laetitia, Epigenetics of bone diseases, Joint Bone Spine, 85, 6, 2018. Crossref

  24. Cheng Lijun, Pandya Pankita H., Liu Enze, Chandra Pooja, Wang Limei, Murray Mary E., Carter Jacquelyn, Ferguson Michael, Saadatzadeh Mohammad Reza, Bijangi-Visheshsaraei Khadijeh, Marshall Mark, Li Lang, Pollok Karen E., Renbarger Jamie L., Integration of genomic copy number variations and chemotherapy-response biomarkers in pediatric sarcoma, BMC Medical Genomics, 12, S1, 2019. Crossref

  25. Anwar M. Akhtar, El-Baba Chirine, Elnaggar Muhammed H., Elkholy Yasmeen O., Mottawea Mohamed, Johar Dina, Al Shehabi Tuqa S., Kobeissy Firas, Moussalem Charbel, Massaad Elie, Omeis Ibrahim, Darwiche Nadine, Eid A.H., Novel therapeutic strategies for spinal osteosarcomas, Seminars in Cancer Biology, 64, 2020. Crossref

  26. Moradi Mohammad, Abdolhosseini Mansoreh, Zarrabi Ali, johari Behrooz, A review on application of Nano-structures and Nano-objects with high potential for managing different aspects of bone malignancies, Nano-Structures & Nano-Objects, 19, 2019. Crossref

  27. Sergi Consolato, Shen Fan, Liu Song-Mei, Insulin/IGF-1R, SIRT1, and FOXOs Pathways—An Intriguing Interaction Platform for Bone and Osteosarcoma, Frontiers in Endocrinology, 10, 2019. Crossref

  28. Valavanis Christos, Stanc Gabriela, Long Noncoding RNAs in Osteosarcoma: Mechanisms and Potential Clinical Implications, in Osteosarcoma – Diagnosis, Mechanisms, and Translational Developments, 2019. Crossref

  29. Thoenen Elizabeth, Curl Amanda, Iwakuma Tomoo, TP53 in bone and soft tissue sarcomas, Pharmacology & Therapeutics, 202, 2019. Crossref

  30. Zhao Lei, Bi Dongdong, Qi Xiaoyu, Guo Yifei, Yue Feng, Wang Xiangtao, Han Meihua, Polydopamine-based surface modification of paclitaxel nanoparticles for osteosarcoma targeted therapy, Nanotechnology, 30, 25, 2019. Crossref

  31. Dhir Aditi, Li Rong, Li Geling, Dean Joy, Robin Nathaniel H., Alva Elizabeth, Simultaneous osteosarcoma and renal cell carcinoma with BRCA1 mutation in a young male adult with prior oligodendroglioma , Pediatric Blood & Cancer, 67, 3, 2020. Crossref

  32. Shi Chengcheng, Zhang Huapeng, Wang Penglei, Wang Kai, Xu Denghui, Wang Haitao, Yin Li, Zhang Shuijun, Zhang Yi, PROTAC induced-BET protein degradation exhibits potent anti-osteosarcoma activity by triggering apoptosis, Cell Death & Disease, 10, 11, 2019. Crossref

  33. Weis Serge, Sonnberger Michael, Dunzinger Andreas, Voglmayr Eva, Aichholzer Martin, Kleiser Raimund, Strasser Peter, Bone Tumors, in Imaging Brain Diseases, 2019. Crossref

  34. Wen Ji‐Feng, Jiang Yong‐Qing, Li Chao, Dai Xian‐Kui, Wu Tong, Yin Wen‐Zhe, LncRNA‐XIST promotes the oxidative stress‐induced migration, invasion, and epithelial‐to‐mesenchymal transition of osteosarcoma cancer cells through miR‐153‐SNAI1 axis, Cell Biology International, 44, 10, 2020. Crossref

  35. Huang Fei, Zhou Ping, Wang Zhen, Zhang Xiang-Lu, Liao Fa-Xue, Hu Yong, Chang Jun, Knockdown of TBRG4 suppresses proliferation, invasion and promotes apoptosis of osteosarcoma cells by downregulating TGF-β1 expression and PI3K/AKT signaling pathway, Archives of Biochemistry and Biophysics, 686, 2020. Crossref

  36. Yang Lei, Liu Guangjun, Xiao Sen, Wang Luqing, Liu Xiangxia, Tan Qi, Li Zhen, Long Noncoding MT1JP Enhanced the Inhibitory Effects of miR-646 on FGF2 in Osteosarcoma, Cancer Biotherapy and Radiopharmaceuticals, 35, 5, 2020. Crossref

  37. Li Stephen, Chen Zhiguo, Le Lu Q, New insights into the neurofibroma tumor cells of origin, Neuro-Oncology Advances, 2, Supplement_1, 2020. Crossref

  38. Ren L., Ruiz-Rodado V., Dowdy T., Huang S., Issaq S. H., Beck J., Wang H., Tran Hoang C., Lita A., Larion M., LeBlanc A. K., Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma, Cancer & Metabolism, 8, 1, 2020. Crossref

  39. Mateu-Sanz Miguel, Tornín Juan, Brulin Bénédicte, Khlyustova Anna, Ginebra Maria-Pau, Layrolle Pierre, Canal Cristina, Cold Plasma-Treated Ringer’s Saline: A Weapon to Target Osteosarcoma, Cancers, 12, 1, 2020. Crossref

  40. Scotlandi Katia, Hattinger Claudia Maria, Pellegrini Evelin, Gambarotti Marco, Serra Massimo, Genomics and Therapeutic Vulnerabilities of Primary Bone Tumors, Cells, 9, 4, 2020. Crossref

  41. Ralston Stuart H, A New Gene for Susceptibility to Paget's Disease of Bone and for Multisystem Proteinopathy, Journal of Bone and Mineral Research, 35, 8, 2020. Crossref

  42. Wen Ji-Feng, Jiang Yong-Qing, Li Chao, Dai Xian-Kui, Wu Tong, Yin Wen-Zhe, LncRNA-SARCC sensitizes osteosarcoma to cisplatin through the miR-143-mediated glycolysis inhibition by targeting Hexokinase 2, Cancer Biomarkers, 28, 2, 2020. Crossref

  43. He Jia-wen, Li De-jian, Zhou Jian-hua, Zhu Ya-long, Yu Bao-qing, SP1-mediated upregulation of lncRNA LMCD1-AS1 functions a ceRNA for miR-106b-5p to facilitate osteosarcoma progression, Biochemical and Biophysical Research Communications, 526, 3, 2020. Crossref

  44. Collier Christopher D., Getty Patrick J., Greenfield Edward M., Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma, in Current Advances in the Science of Osteosarcoma, 1258, 2020. Crossref

  45. Modesto Paola, Castrillo Fernandez Jordi Leonardo, Martini Isabella, Zoccola Roberto, Pugliano Maria Concetta, De Ciucis Chiara Grazia, Goria Maria, Ferrari Angelo, Razzuoli Elisabetta, Characterization of D-17 Canine Osteosarcoma Cell Line and Evaluation of Its Ability to Response to Infective Stressor Used as Alternative Anticancer Therapy, Animals, 10, 11, 2020. Crossref

  46. Schott Courtney, Shah Avanthi Tayi, Sweet-Cordero E. Alejandro, Genomic Complexity of Osteosarcoma and Its Implication for Preclinical and Clinical Targeted Therapies, in Current Advances in the Science of Osteosarcoma, 1258, 2020. Crossref

  47. Alge Olivia, Gryak Jonathan, Hua Yingqi, Najaria Kayvan, Classifying Osteosarcoma Using Meta-Analysis of Gene Expression, 2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2018. Crossref

  48. Leng Jiali, Song Qingxu, Zhao Yuguang, Wang Zhenyu, miR‑15a represses cancer cell migration and invasion under conditions of hypoxia by targeting and downregulating Bcl‑2 expression in human osteosarcoma cells, International Journal of Oncology, 2018. Crossref

  49. Pandya Pankita H., Cheng Lijun, Saadatzadeh M. Reza, Bijangi-Vishehsaraei Khadijeh, Tang Shan, Sinn Anthony L., Trowbridge Melissa A., Coy Kathryn L., Bailey Barbara J., Young Courtney N., Ding Jixin, Dobrota Erika A., Dyer Savannah, Elmi Adily, Thompson Quinton, Barghi Farinaz, Shultz Jeremiah, Albright Eric A., Shannon Harlan E., Murray Mary E., Marshall Mark S., Ferguson Michael J., Bertrand Todd E., Wurtz L. Daniel, Batra Sandeep, Li Lang, Renbarger Jamie L., Pollok Karen E., Systems Biology Approach Identifies Prognostic Signatures of Poor Overall Survival and Guides the Prioritization of Novel BET-CHK1 Combination Therapy for Osteosarcoma, Cancers, 12, 9, 2020. Crossref

  50. Sun Junkui , Xu Hongen , Qi Muge , Zhang Chi , Shi Jianxiang , Identification of key genes in osteosarcoma by meta‑analysis of gene expression microarray, Molecular Medicine Reports, 2019. Crossref

  51. Meng Qingbing , Zhang Wensheng , Xu Xingli , Li Jian , Mu Hongxin , Liu Xiaolan , Qin Ling , Zhu Xiaoqi , Zheng Minqian , The effects of TRAF6 on proliferation, apoptosis and invasion in osteosarcoma are regulated by miR-124, International Journal of Molecular Medicine, 2018. Crossref

  52. de Azevedo Judson, Fernandes Thales, Fernandes Jos�, de Azevedo Jenner, Lanza Daniel, Bezerra Christiane, Andrade V�nia, de Ara�jo Jos�lio, Fernandes Jos�, Biology and pathogenesis of human osteosarcoma (Review), Oncology Letters, 2019. Crossref

  53. de Nigris Filomena, Ruosi Carlo, Napoli Claudio, Clinical efficiency of epigenetic drugs therapy in bone malignancies, Bone, 143, 2021. Crossref

  54. Kaławaj Katarzyna, Sławińska-Brych Adrianna, Mizerska-Kowalska Magdalena, Żurek Aleksandra, Bojarska-Junak Agnieszka, Kandefer-Szerszeń Martyna, Zdzisińska Barbara, Alpha Ketoglutarate Exerts In Vitro Anti-Osteosarcoma Effects through Inhibition of Cell Proliferation, Induction of Apoptosis via the JNK and Caspase 9-Dependent Mechanism, and Suppression of TGF-β and VEGF Production and Metastatic Potential of Cells, International Journal of Molecular Sciences, 21, 24, 2020. Crossref

  55. Zhao Xin , Fang Yuying , Wang Xingwen , Yang Zhouyuan , Li Donghai , Tian Meng , Kang Pengde , Knockdown of Ski decreases osteosarcoma cell proliferation and migration by suppressing the PI3K/Akt signaling pathway, International Journal of Oncology, 2019. Crossref

  56. Raghubir Marian, Azeem Syeda M., Hasnat Rifat, Rahman Chowdhury N., Wong Linda, Yan Salina, Huang Yu Qi, Zhagui Raquel, Blyufer Angelina, Tariq Iffat, Tam Cassey, Lhamo Sonam, Cecilio Lucas, Chowdhury Yesmin, ChandThakuri Shraddha, Mahajan Shahana S., Riluzole-induced apoptosis in osteosarcoma is mediated through Yes-associated protein upon phosphorylation by c-Abl Kinase, Scientific Reports, 11, 1, 2021. Crossref

  57. Bianchi Gottardo, Gaiero Leticia, Casales Nicolas, Silveri Claudio, C. Belzarena Ana, Osteosarcoma, in Recent Advances in Bone Tumours and Osteoarthritis, 2021. Crossref

  58. Zhang Yuying, Li Mengru, Zhang Qianqian, Wang Zhaoyang, Li Xiuxiu, Bao Jie, Zhang Hua, Arthpyrone L, a New Pyridone Alkaloid from a Deep‐Sea Arthrinium sp., Inhibits Proliferation of MG63 Osteosarcoma Cells by Inducing G0/G1 Arrest and Apoptosis , Chemistry & Biodiversity, 18, 2, 2021. Crossref

  59. Gola Cecilia, Giannuzzi Diana, Rinaldi Andrea, Iussich Selina, Modesto Paola, Morello Emanuela, Buracco Paolo, Aresu Luca, De Maria Raffaella, Genomic and Transcriptomic Characterization of Canine Osteosarcoma Cell Lines: A Valuable Resource in Translational Medicine, Frontiers in Veterinary Science, 8, 2021. Crossref

  60. Richter Günther, Lissat Andrej, Kontny Udo, Regulated cell death and drug resistance in malignant bone tumors, in Bone Cancer, 2022. Crossref

  61. Wen Mingxin, Ren Hui, Zhang Shouqiang, Li Tao, Zhang Jiefeng, Ren Peng, CT45A1 promotes the metastasis of osteosarcoma cells in vitro and in vivo through β-catenin, Cell Death & Disease, 12, 7, 2021. Crossref

  62. Le-Royer Bénédicte Brounais, Lézot Frédéric, Growth factors, cytokines, and pediatric malignant primary bones tumors, in Bone Cancer, 2022. Crossref

  63. Zahnreich Sebastian, Schmidberger Heinz, Childhood Cancer: Occurrence, Treatment and Risk of Second Primary Malignancies, Cancers, 13, 11, 2021. Crossref

  64. Fan Jian, Yang Yi, Qian Ji-kui, Zhang Xin, Ji Jia-qing, Zhang Li, Li Shan-zhu, Yuan Feng, Aberrant Expression of PAFAH1B3 Affects Proliferation and Apoptosis in Osteosarcoma, Frontiers in Oncology, 11, 2021. Crossref

  65. Zhao Zhipeng, Shi Jijun, Zhao Guang, Gao Yanjun, Jiang Zhigang, Yuan Fusheng, Large Scale Identification of Osteosarcoma Pathogenic Genes by Multiple Extreme Learning Machine, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref

  66. Song Zifeng, Pearce Martin C., Jiang Yuan, Yang Liping, Goodall Cheri, Miranda Cristobal L., Milovancev Milan, Bracha Shay, Kolluri Siva K., Maier Claudia S., Delineation of hypoxia-induced proteome shifts in osteosarcoma cells with different metastatic propensities, Scientific Reports, 10, 1, 2020. Crossref

  67. Zeng Ming, Zhou Jian, Wen Lifang, Zhu Yanshan, Luo Yingquan, Wang Wanchun, The relationship between the expression of Ki-67 and the prognosis of osteosarcoma, BMC Cancer, 21, 1, 2021. Crossref

  68. Jin Lin, Luo Yue, Zhao Ying-Chun, Tao Hai, MiR-183-5p Promotes Tumor Progression of Osteosarcoma and Predicts Poor Prognosis in Patients, Cancer Management and Research, Volume 13, 2021. Crossref

  69. Edmunds Grace L., Smalley Matthew J., Beck Sam, Errington Rachel J., Gould Sara, Winter Helen, Brodbelt Dave C., O’Neill Dan G., Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study, Canine Medicine and Genetics, 8, 1, 2021. Crossref

  70. Chi Xiying, Ji Tao, Li Junying, Xu Jie, Tang Xiaodong, Xie Lu, Meng Fanfei, Guo Wei, Genomic Analysis Revealed Mutational Traits Associated with Clinical Outcomes in Osteosarcoma, Cancer Management and Research, Volume 13, 2021. Crossref

  71. Chen Houping, Pan Runsang, Li Hao, Zhang Wenguang, Ren Chong, Lu Qiaoying, Chen Hui, Zhang Xiangyan, Nie Yingjie, CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP‐9/PI3K/AKT pathway, Cell Biology International, 45, 3, 2021. Crossref

  72. Ghafouri-Fard Soudeh, Shirvani-Farsani Zeinab, Hussen Bashdar Mahmud, Taheri Mohammad, The critical roles of lncRNAs in the development of osteosarcoma, Biomedicine & Pharmacotherapy, 135, 2021. Crossref

  73. Lin Qiang, Munir Anum, Masood Sana, Hussain Shahid, Naeem Mashal, Fazal Sahar, Gene expression profiling utilizing extremely sensitive CDNA arrays and enrichment-based network study of major bone cancer genes, Journal of Research in Medical Sciences, 26, 1, 2021. Crossref

  74. Gao Shuai-Shuai, Zhang Guo-Xun, Zhang Wen-Ting, MicroRNAs as prognostic biomarkers for survival outcome in osteosarcoma: A meta-analysis, World Journal of Meta-Analysis, 9, 6, 2021. Crossref

  75. Natarajan Aparna, Ramachandran Balaji, Gopisetty Gopal, Jayavelu Subramani, Sundersingh Shirley, Rajkumar Thangarajan, Pioglitazone modulates doxorubicin resistance in a in vivo model of drug resistant osteosarcoma xenograft, Naunyn-Schmiedeberg's Archives of Pharmacology, 394, 2, 2021. Crossref

  76. Kamptner Anna Zita Mehira, Mayer Christoph-Erik, Sutterlüty Hedwig, Sprouty3, but Not Sprouty1, Expression Is Beneficial for the Malignant Potential of Osteosarcoma Cells, International Journal of Molecular Sciences, 22, 21, 2021. Crossref

  77. Liu Hua, Qin Guangzhen, Ji Yanan, Wang Xiaojian, Bao Hailin, Guan Xiaojun, Wei Aichun, Cai Zhigang, Potential role of m6A RNA methylation regulators in osteosarcoma and its clinical prognostic value, Journal of Orthopaedic Surgery and Research, 16, 1, 2021. Crossref

  78. Chen Si, Li Weiguo, Guo Ai, LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma, Bioscience Reports, 39, 4, 2019. Crossref

  79. Zhou Jian, Xiao Xia, Wang Wanchun, Luo Yingquan, Association between PTEN and clinical-pathological features of osteosarcoma, Bioscience Reports, 39, 7, 2019. Crossref

  80. Petriceks Aldis H., Salmi Darren, Educational Case: Primary Osteosarcoma, Academic Pathology, 6, 2019. Crossref

  81. Gao Feng, Zuo Qiang, Jiang Tao, Song Huanghe, Zhou Jinchun, A newly synthesized oleanolic acid derivative inhibits the growth of osteosarcoma cells in vitro and in vivo by decreasing c‐MYC‐dependent glycolysis , Journal of Cellular Biochemistry, 120, 6, 2019. Crossref

  82. Mohammadi Erfan, Alemi Forough, Maleki Masomeh, Malakoti Faezeh, Farsad-Akhtar Nader, Yousefi Bahman, Quercetin and Methotrexate in Combination have Anticancer Activity in Osteosarcoma Cells and Repress Oncogenic MicroRNA-223, Drug Research, 72, 04, 2022. Crossref

  83. Smeester Branden A., Draper Garrett M., Slipek Nicholas J., Larsson Alex T., Stratton Natalie, Pomeroy Emily J., Becklin Kelsie L., Yamamoto Kenta, Williams Kyle B., Laoharawee Kanut, Peterson Joseph J., Abrahante Juan E., Rathe Susan K., Mills Lauren J., Crosby Margaret R., Hudson Wendy A., Rahrmann Eric P., Largaespada David A., Moriarity Branden S., Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K–AKT Signaling for the Treatment of Metastatic Osteosarcoma, Molecular Cancer Therapeutics, 19, 12, 2020. Crossref

  84. Zhou Daguo, Ji Guangrong, Wei Guojun, Li Zongguang, Yu Naichun, Wang Yanling, Lin Binhui, Zhang Linlin, Yin Yue, MiR-361-3p promotes tumorigenesis of osteosarcoma cells via targeting ARID3A, Tissue and Cell, 76, 2022. Crossref

  85. Zhang Ling, Song Jingtao, Xin Xu, Sun Donghong, Huang Huiting, Chen Yang, Zhang Tao, Zhang Yiming, Hypoxia stimulates the migration and invasion of osteosarcoma via up-regulating the NUSAP1 expression, Open Medicine, 16, 1, 2021. Crossref

  86. Morrow James J., Mendoza Arnulfo, Koyen Allyson, Lizardo Michael M., Ren Ling, Waybright Timothy J., Hansen Ryan J., Gustafson Daniel L., Zhou Ming, Fan Timothy M., Scacheri Peter C., Khanna Chand, mTOR Inhibition Mitigates Enhanced mRNA Translation Associated with the Metastatic Phenotype of Osteosarcoma Cells In Vivo , Clinical Cancer Research, 22, 24, 2016. Crossref

  87. Wang Yuanhao, Hao Wei, Wang Hui, RETRACTED ARTICLE: miR-557 suppressed the malignant behaviours of osteosarcoma cells by reducing HOXB9 and deactivating the EMT process, Artificial Cells, Nanomedicine, and Biotechnology, 49, 1, 2021. Crossref

  88. Sakthikumar Sharadha, Elvers Ingegerd, Kim Jaegil, Arendt Maja L., Thomas Rachael, Turner-Maier Jason, Swofford Ross, Johnson Jeremy, Schumacher Steven E., Alföldi Jessica, Axelsson Erik, Couto C. Guillermo, Kisseberth William C., Pettersson Mats E., Getz Gad, Meadows Jennifer R.S., Modiano Jaime F., Breen Matthew, Kierczak Marcin, Forsberg-Nilsson Karin, Marinescu Voichita D., Lindblad-Toh Kerstin, SETD2 Is Recurrently Mutated in Whole-Exome Sequenced Canine Osteosarcoma, Cancer Research, 78, 13, 2018. Crossref

  89. Smeester Branden A., Slipek Nicholas J., Pomeroy Emily J., Bomberger Heather E., Shamsan Ghaidan A., Peterson Joseph J., Crosby Margaret R., Draper Garrett M., Becklin Kelsie L., Rahrmann Eric P., McCarthy James B., Odde David J., Wood David K., Largaespada David A., Moriarity Branden S., SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis, Oncogene, 39, 5, 2020. Crossref

  90. Saraf Radhika, Datta Aniruddha, Sima Chao, Hua Jianping, Lopes Rosana, Bittner Michael L., Miller Tasha, Wilson-Robles Heather M., In silico modeling of the induction of apoptosis by Cryptotanshinone in osteosarcoma cell lines, IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2020. Crossref

  91. Liu Wei, Wang Dunwei, Liu Lidi, Wang Lin, Yan Ming, miR-140 inhibits osteosarcoma progression by impairing USP22-mediated LSD1 stabilization and promoting p21 expression, Molecular Therapy - Nucleic Acids, 24, 2021. Crossref

  92. Moukengue Brice, Lallier Morgane, Marchandet Louise, Baud’huin Marc, Verrecchia Franck, Ory Benjamin, Lamoureux Francois, Origin and Therapies of Osteosarcoma, Cancers, 14, 14, 2022. Crossref

  93. Martinez-Velez Naiara, Laspidea Virginia, Zalacain Marta, Labiano Sara, García-Moure Marc, Puigdelloses Montse, Marrodan Lucía, Gonzalez-Huarriz Marisol, Herrador Guillermo, de la Nava Daniel, Ausejo-Mauleon Iker, Fueyo Juan, Gomez-Manzano Candelaria, Patiño-García Ana, Alonso Marta M., Local Treatment of a Pediatric Osteosarcoma Model with a 4-1BBL Armed Oncolytic Adenovirus Results in an Antitumor Effect and Leads to Immune Memory, Molecular Cancer Therapeutics, 21, 3, 2022. Crossref

  94. Liu Guodong, Mao Honggang, Liu Yan, Zhang Zun, Ha Si, Zhang Xiaoyan, miR-148b-3p, as a tumor suppressor, targets son of sevenless homolog 1 to regulate the malignant progression in human osteosarcoma, Bioengineered, 13, 2, 2022. Crossref

  95. Ying Hongliang, Ying Boda, Zhang Jinrui, Kong Daliang, Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy, Artificial Cells, Nanomedicine, and Biotechnology, 47, 1, 2019. Crossref

  96. Van Stiphout Cassidy M., Luu Anita K., Viloria-Petit Alicia M., Proteasome Inhibitors and Their Potential Applicability in Osteosarcoma Treatment, Cancers, 14, 19, 2022. Crossref

  97. Yang Yuhan, Zhou Chen, Ma Xuelei, Use of Nomogram on Nutritional Assessment Indicators to Predict Clinical Outcomes in Patients Undergoing Surgical Resection for High-Grade Osteosarcoma, Nutrition and Cancer, 74, 10, 2022. Crossref

  98. Khlusov I. A., Porokhova E. D., Komarova E. G., Kazantseva E. A., Sharkeev Yu. P., Yurova K. A., Litvinova L. S., Scaffolds as Carriers of Drugs and Biological Molecules for Bone-Tissue Bioengineering, Cell and Tissue Biology, 16, 5, 2022. Crossref

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