每年出版 4 期
ISSN 打印: 0893-9675
ISSN 在线: 2162-6448
Indexed in
Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies
摘要
Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life. Unfortunately, clinical outcomes for osteosarcoma patients have not substantially improved in over 30 years. This stagnation in therapeutic advances is perhaps explained by the genetic, epigenetic, and biological complexities of this rare tumor. In this review we provide a general background on the biology of osteosarcoma and the clinical status quo. We go on to enumerate the genetic and epigenetic defects identified in osteosarcoma. Finally, we discuss ongoing large-scale studies in the field and potential new therapies that are currently under investigation.
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Zhao Lei, Bi Dongdong, Qi Xiaoyu, Guo Yifei, Yue Feng, Wang Xiangtao, Han Meihua, Polydopamine-based surface modification of paclitaxel nanoparticles for osteosarcoma targeted therapy, Nanotechnology, 30, 25, 2019. Crossref
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Shi Chengcheng, Zhang Huapeng, Wang Penglei, Wang Kai, Xu Denghui, Wang Haitao, Yin Li, Zhang Shuijun, Zhang Yi, PROTAC induced-BET protein degradation exhibits potent anti-osteosarcoma activity by triggering apoptosis, Cell Death & Disease, 10, 11, 2019. Crossref
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Wen Ji-Feng, Jiang Yong-Qing, Li Chao, Dai Xian-Kui, Wu Tong, Yin Wen-Zhe, LncRNA-SARCC sensitizes osteosarcoma to cisplatin through the miR-143-mediated glycolysis inhibition by targeting Hexokinase 2, Cancer Biomarkers, 28, 2, 2020. Crossref
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He Jia-wen, Li De-jian, Zhou Jian-hua, Zhu Ya-long, Yu Bao-qing, SP1-mediated upregulation of lncRNA LMCD1-AS1 functions a ceRNA for miR-106b-5p to facilitate osteosarcoma progression, Biochemical and Biophysical Research Communications, 526, 3, 2020. Crossref
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Leng Jiali, Song Qingxu, Zhao Yuguang, Wang Zhenyu, miR‑15a represses cancer cell migration and invasion under conditions of hypoxia by targeting and downregulating Bcl‑2 expression in human osteosarcoma cells, International Journal of Oncology, 2018. Crossref
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Pandya Pankita H., Cheng Lijun, Saadatzadeh M. Reza, Bijangi-Vishehsaraei Khadijeh, Tang Shan, Sinn Anthony L., Trowbridge Melissa A., Coy Kathryn L., Bailey Barbara J., Young Courtney N., Ding Jixin, Dobrota Erika A., Dyer Savannah, Elmi Adily, Thompson Quinton, Barghi Farinaz, Shultz Jeremiah, Albright Eric A., Shannon Harlan E., Murray Mary E., Marshall Mark S., Ferguson Michael J., Bertrand Todd E., Wurtz L. Daniel, Batra Sandeep, Li Lang, Renbarger Jamie L., Pollok Karen E., Systems Biology Approach Identifies Prognostic Signatures of Poor Overall Survival and Guides the Prioritization of Novel BET-CHK1 Combination Therapy for Osteosarcoma, Cancers, 12, 9, 2020. Crossref
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Meng Qingbing , Zhang Wensheng , Xu Xingli , Li Jian , Mu Hongxin , Liu Xiaolan , Qin Ling , Zhu Xiaoqi , Zheng Minqian , The effects of TRAF6 on proliferation, apoptosis and invasion in osteosarcoma are regulated by miR-124, International Journal of Molecular Medicine, 2018. Crossref
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de Azevedo Judson, Fernandes Thales, Fernandes Jos�, de Azevedo Jenner, Lanza Daniel, Bezerra Christiane, Andrade V�nia, de Ara�jo Jos�lio, Fernandes Jos�, Biology and pathogenesis of human osteosarcoma (Review), Oncology Letters, 2019. Crossref
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de Nigris Filomena, Ruosi Carlo, Napoli Claudio, Clinical efficiency of epigenetic drugs therapy in bone malignancies, Bone, 143, 2021. Crossref
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Kaławaj Katarzyna, Sławińska-Brych Adrianna, Mizerska-Kowalska Magdalena, Żurek Aleksandra, Bojarska-Junak Agnieszka, Kandefer-Szerszeń Martyna, Zdzisińska Barbara, Alpha Ketoglutarate Exerts In Vitro Anti-Osteosarcoma Effects through Inhibition of Cell Proliferation, Induction of Apoptosis via the JNK and Caspase 9-Dependent Mechanism, and Suppression of TGF-β and VEGF Production and Metastatic Potential of Cells, International Journal of Molecular Sciences, 21, 24, 2020. Crossref
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Zhao Xin , Fang Yuying , Wang Xingwen , Yang Zhouyuan , Li Donghai , Tian Meng , Kang Pengde , Knockdown of Ski decreases osteosarcoma cell proliferation and migration by suppressing the PI3K/Akt signaling pathway, International Journal of Oncology, 2019. Crossref
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Raghubir Marian, Azeem Syeda M., Hasnat Rifat, Rahman Chowdhury N., Wong Linda, Yan Salina, Huang Yu Qi, Zhagui Raquel, Blyufer Angelina, Tariq Iffat, Tam Cassey, Lhamo Sonam, Cecilio Lucas, Chowdhury Yesmin, ChandThakuri Shraddha, Mahajan Shahana S., Riluzole-induced apoptosis in osteosarcoma is mediated through Yes-associated protein upon phosphorylation by c-Abl Kinase, Scientific Reports, 11, 1, 2021. Crossref
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Zhang Yuying, Li Mengru, Zhang Qianqian, Wang Zhaoyang, Li Xiuxiu, Bao Jie, Zhang Hua, Arthpyrone L, a New Pyridone Alkaloid from a Deep‐Sea Arthrinium sp., Inhibits Proliferation of MG63 Osteosarcoma Cells by Inducing G0/G1 Arrest and Apoptosis , Chemistry & Biodiversity, 18, 2, 2021. Crossref
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Gola Cecilia, Giannuzzi Diana, Rinaldi Andrea, Iussich Selina, Modesto Paola, Morello Emanuela, Buracco Paolo, Aresu Luca, De Maria Raffaella, Genomic and Transcriptomic Characterization of Canine Osteosarcoma Cell Lines: A Valuable Resource in Translational Medicine, Frontiers in Veterinary Science, 8, 2021. Crossref
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Richter Günther, Lissat Andrej, Kontny Udo, Regulated cell death and drug resistance in malignant bone tumors, in Bone Cancer, 2022. Crossref
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Wen Mingxin, Ren Hui, Zhang Shouqiang, Li Tao, Zhang Jiefeng, Ren Peng, CT45A1 promotes the metastasis of osteosarcoma cells in vitro and in vivo through β-catenin, Cell Death & Disease, 12, 7, 2021. Crossref
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Le-Royer Bénédicte Brounais, Lézot Frédéric, Growth factors, cytokines, and pediatric malignant primary bones tumors, in Bone Cancer, 2022. Crossref
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Zahnreich Sebastian, Schmidberger Heinz, Childhood Cancer: Occurrence, Treatment and Risk of Second Primary Malignancies, Cancers, 13, 11, 2021. Crossref
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Fan Jian, Yang Yi, Qian Ji-kui, Zhang Xin, Ji Jia-qing, Zhang Li, Li Shan-zhu, Yuan Feng, Aberrant Expression of PAFAH1B3 Affects Proliferation and Apoptosis in Osteosarcoma, Frontiers in Oncology, 11, 2021. Crossref
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Zhao Zhipeng, Shi Jijun, Zhao Guang, Gao Yanjun, Jiang Zhigang, Yuan Fusheng, Large Scale Identification of Osteosarcoma Pathogenic Genes by Multiple Extreme Learning Machine, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref
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Song Zifeng, Pearce Martin C., Jiang Yuan, Yang Liping, Goodall Cheri, Miranda Cristobal L., Milovancev Milan, Bracha Shay, Kolluri Siva K., Maier Claudia S., Delineation of hypoxia-induced proteome shifts in osteosarcoma cells with different metastatic propensities, Scientific Reports, 10, 1, 2020. Crossref
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Zeng Ming, Zhou Jian, Wen Lifang, Zhu Yanshan, Luo Yingquan, Wang Wanchun, The relationship between the expression of Ki-67 and the prognosis of osteosarcoma, BMC Cancer, 21, 1, 2021. Crossref
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Jin Lin, Luo Yue, Zhao Ying-Chun, Tao Hai, MiR-183-5p Promotes Tumor Progression of Osteosarcoma and Predicts Poor Prognosis in Patients, Cancer Management and Research, Volume 13, 2021. Crossref
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Edmunds Grace L., Smalley Matthew J., Beck Sam, Errington Rachel J., Gould Sara, Winter Helen, Brodbelt Dave C., O’Neill Dan G., Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study, Canine Medicine and Genetics, 8, 1, 2021. Crossref
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Chi Xiying, Ji Tao, Li Junying, Xu Jie, Tang Xiaodong, Xie Lu, Meng Fanfei, Guo Wei, Genomic Analysis Revealed Mutational Traits Associated with Clinical Outcomes in Osteosarcoma, Cancer Management and Research, Volume 13, 2021. Crossref
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Chen Houping, Pan Runsang, Li Hao, Zhang Wenguang, Ren Chong, Lu Qiaoying, Chen Hui, Zhang Xiangyan, Nie Yingjie, CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP‐9/PI3K/AKT pathway, Cell Biology International, 45, 3, 2021. Crossref
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Ghafouri-Fard Soudeh, Shirvani-Farsani Zeinab, Hussen Bashdar Mahmud, Taheri Mohammad, The critical roles of lncRNAs in the development of osteosarcoma, Biomedicine & Pharmacotherapy, 135, 2021. Crossref
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Lin Qiang, Munir Anum, Masood Sana, Hussain Shahid, Naeem Mashal, Fazal Sahar, Gene expression profiling utilizing extremely sensitive CDNA arrays and enrichment-based network study of major bone cancer genes, Journal of Research in Medical Sciences, 26, 1, 2021. Crossref
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Gao Shuai-Shuai, Zhang Guo-Xun, Zhang Wen-Ting, MicroRNAs as prognostic biomarkers for survival outcome in osteosarcoma: A meta-analysis, World Journal of Meta-Analysis, 9, 6, 2021. Crossref
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Natarajan Aparna, Ramachandran Balaji, Gopisetty Gopal, Jayavelu Subramani, Sundersingh Shirley, Rajkumar Thangarajan, Pioglitazone modulates doxorubicin resistance in a in vivo model of drug resistant osteosarcoma xenograft, Naunyn-Schmiedeberg's Archives of Pharmacology, 394, 2, 2021. Crossref
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Kamptner Anna Zita Mehira, Mayer Christoph-Erik, Sutterlüty Hedwig, Sprouty3, but Not Sprouty1, Expression Is Beneficial for the Malignant Potential of Osteosarcoma Cells, International Journal of Molecular Sciences, 22, 21, 2021. Crossref
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Liu Hua, Qin Guangzhen, Ji Yanan, Wang Xiaojian, Bao Hailin, Guan Xiaojun, Wei Aichun, Cai Zhigang, Potential role of m6A RNA methylation regulators in osteosarcoma and its clinical prognostic value, Journal of Orthopaedic Surgery and Research, 16, 1, 2021. Crossref
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Chen Si, Li Weiguo, Guo Ai, LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma, Bioscience Reports, 39, 4, 2019. Crossref
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Zhou Jian, Xiao Xia, Wang Wanchun, Luo Yingquan, Association between PTEN and clinical-pathological features of osteosarcoma, Bioscience Reports, 39, 7, 2019. Crossref
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Gao Feng, Zuo Qiang, Jiang Tao, Song Huanghe, Zhou Jinchun, A newly synthesized oleanolic acid derivative inhibits the growth of osteosarcoma cells in vitro and in vivo by decreasing c‐MYC‐dependent glycolysis , Journal of Cellular Biochemistry, 120, 6, 2019. Crossref
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Mohammadi Erfan, Alemi Forough, Maleki Masomeh, Malakoti Faezeh, Farsad-Akhtar Nader, Yousefi Bahman, Quercetin and Methotrexate in Combination have Anticancer Activity in Osteosarcoma Cells and Repress Oncogenic MicroRNA-223, Drug Research, 72, 04, 2022. Crossref
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Smeester Branden A., Draper Garrett M., Slipek Nicholas J., Larsson Alex T., Stratton Natalie, Pomeroy Emily J., Becklin Kelsie L., Yamamoto Kenta, Williams Kyle B., Laoharawee Kanut, Peterson Joseph J., Abrahante Juan E., Rathe Susan K., Mills Lauren J., Crosby Margaret R., Hudson Wendy A., Rahrmann Eric P., Largaespada David A., Moriarity Branden S., Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K–AKT Signaling for the Treatment of Metastatic Osteosarcoma, Molecular Cancer Therapeutics, 19, 12, 2020. Crossref
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Zhou Daguo, Ji Guangrong, Wei Guojun, Li Zongguang, Yu Naichun, Wang Yanling, Lin Binhui, Zhang Linlin, Yin Yue, MiR-361-3p promotes tumorigenesis of osteosarcoma cells via targeting ARID3A, Tissue and Cell, 76, 2022. Crossref
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Zhang Ling, Song Jingtao, Xin Xu, Sun Donghong, Huang Huiting, Chen Yang, Zhang Tao, Zhang Yiming, Hypoxia stimulates the migration and invasion of osteosarcoma via up-regulating the NUSAP1 expression, Open Medicine, 16, 1, 2021. Crossref
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Morrow James J., Mendoza Arnulfo, Koyen Allyson, Lizardo Michael M., Ren Ling, Waybright Timothy J., Hansen Ryan J., Gustafson Daniel L., Zhou Ming, Fan Timothy M., Scacheri Peter C., Khanna Chand, mTOR Inhibition Mitigates Enhanced mRNA Translation Associated with the Metastatic Phenotype of Osteosarcoma Cells In Vivo , Clinical Cancer Research, 22, 24, 2016. Crossref
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Wang Yuanhao, Hao Wei, Wang Hui, RETRACTED ARTICLE: miR-557 suppressed the malignant behaviours of osteosarcoma cells by reducing HOXB9 and deactivating the EMT process, Artificial Cells, Nanomedicine, and Biotechnology, 49, 1, 2021. Crossref
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Sakthikumar Sharadha, Elvers Ingegerd, Kim Jaegil, Arendt Maja L., Thomas Rachael, Turner-Maier Jason, Swofford Ross, Johnson Jeremy, Schumacher Steven E., Alföldi Jessica, Axelsson Erik, Couto C. Guillermo, Kisseberth William C., Pettersson Mats E., Getz Gad, Meadows Jennifer R.S., Modiano Jaime F., Breen Matthew, Kierczak Marcin, Forsberg-Nilsson Karin, Marinescu Voichita D., Lindblad-Toh Kerstin, SETD2 Is Recurrently Mutated in Whole-Exome Sequenced Canine Osteosarcoma, Cancer Research, 78, 13, 2018. Crossref
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Smeester Branden A., Slipek Nicholas J., Pomeroy Emily J., Bomberger Heather E., Shamsan Ghaidan A., Peterson Joseph J., Crosby Margaret R., Draper Garrett M., Becklin Kelsie L., Rahrmann Eric P., McCarthy James B., Odde David J., Wood David K., Largaespada David A., Moriarity Branden S., SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis, Oncogene, 39, 5, 2020. Crossref
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Saraf Radhika, Datta Aniruddha, Sima Chao, Hua Jianping, Lopes Rosana, Bittner Michael L., Miller Tasha, Wilson-Robles Heather M., In silico modeling of the induction of apoptosis by Cryptotanshinone in osteosarcoma cell lines, IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2020. Crossref
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Liu Wei, Wang Dunwei, Liu Lidi, Wang Lin, Yan Ming, miR-140 inhibits osteosarcoma progression by impairing USP22-mediated LSD1 stabilization and promoting p21 expression, Molecular Therapy - Nucleic Acids, 24, 2021. Crossref
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Moukengue Brice, Lallier Morgane, Marchandet Louise, Baud’huin Marc, Verrecchia Franck, Ory Benjamin, Lamoureux Francois, Origin and Therapies of Osteosarcoma, Cancers, 14, 14, 2022. Crossref
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Martinez-Velez Naiara, Laspidea Virginia, Zalacain Marta, Labiano Sara, García-Moure Marc, Puigdelloses Montse, Marrodan Lucía, Gonzalez-Huarriz Marisol, Herrador Guillermo, de la Nava Daniel, Ausejo-Mauleon Iker, Fueyo Juan, Gomez-Manzano Candelaria, Patiño-García Ana, Alonso Marta M., Local Treatment of a Pediatric Osteosarcoma Model with a 4-1BBL Armed Oncolytic Adenovirus Results in an Antitumor Effect and Leads to Immune Memory, Molecular Cancer Therapeutics, 21, 3, 2022. Crossref
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Liu Guodong, Mao Honggang, Liu Yan, Zhang Zun, Ha Si, Zhang Xiaoyan, miR-148b-3p, as a tumor suppressor, targets son of sevenless homolog 1 to regulate the malignant progression in human osteosarcoma, Bioengineered, 13, 2, 2022. Crossref
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Ying Hongliang, Ying Boda, Zhang Jinrui, Kong Daliang, Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy, Artificial Cells, Nanomedicine, and Biotechnology, 47, 1, 2019. Crossref
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Van Stiphout Cassidy M., Luu Anita K., Viloria-Petit Alicia M., Proteasome Inhibitors and Their Potential Applicability in Osteosarcoma Treatment, Cancers, 14, 19, 2022. Crossref
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Yang Yuhan, Zhou Chen, Ma Xuelei, Use of Nomogram on Nutritional Assessment Indicators to Predict Clinical Outcomes in Patients Undergoing Surgical Resection for High-Grade Osteosarcoma, Nutrition and Cancer, 74, 10, 2022. Crossref
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Khlusov I. A., Porokhova E. D., Komarova E. G., Kazantseva E. A., Sharkeev Yu. P., Yurova K. A., Litvinova L. S., Scaffolds as Carriers of Drugs and Biological Molecules for Bone-Tissue Bioengineering, Cell and Tissue Biology, 16, 5, 2022. Crossref