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ISSN 打印: 0893-9675

ISSN 在线: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Yin Yang I as an Epimodulator of miRNAs in the Metastatic Cascade

卷 22, 册 1-2, 2017, pp. 99-107
DOI: 10.1615/CritRevOncog.2017020855
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摘要

Yin Yang 1 (YY1) belongs to the polycomb group (PcG) of proteins that modify chromatin epigenetically during dynamic regulation of their target genes. The predominant feature of YY1 is the zinc finger, an ancient structural motif that mediates protein–protein interactions and is capable of interacting with both DNA and RNA. Evidence reveals that YY1 acts predominantly as an epigenetic modulator, influencing the activity and/or localization of epigenetic modifiers molecules such as DNA methylation transferases, histone deacetylases, or non-coding RNAs. Deregulation of the epigenome is observed frequently in a variety of cancer types and is often correlated directly with advanced metastatic stages and poor prognosis. In this review, we address the current understanding of YY1 as a recruiter of epi-modifier molecules in the mechanism of aberrant regulation of target genes as a part of the metastatic cascade.

对本文的引用
  1. Shen Jun, Xu Linling, Qu Chujie, Sun Huimin, Zhang Junjian, Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: Sirt1/miR-134 signalling pathway regulates CREB/BDNF expression in hippocampus in vivo and in vitro, Behavioural Brain Research, 349, 2018. Crossref

  2. Hong Weiguo , Hu Yan , Fan Zhenping , Gao Rong , Yang Ruichuang , Bi Jingfeng , Hou Jun , In silico identification of EP400 and TIA1 as critical transcription factors involved in human hepatocellular carcinoma relapse, Oncology Letters, 2019. Crossref

  3. Bhaskar Rao Divya, Panneerpandian Ponmathi, Balakrishnan Karthik, Ganesan Kumaresan, YY1 regulated transcription‐based stratification of gastric tumors and identification of potential therapeutic candidates, Journal of Cell Communication and Signaling, 15, 2, 2021. Crossref

  4. Mohammadi Amir Hossein, Seyedmoalemi Seyedvahid, Moghanlou Mahsa, Akhlagh Seyed Amirreza, Talaei Zavareh Sayyed Alireza, Hamblin Michael R., Jafari Ameneh, Mirzaei Hamed, MicroRNAs and Synaptic Plasticity: From Their Molecular Roles to Response to Therapy, Molecular Neurobiology, 59, 8, 2022. Crossref

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