Next-Generation Sequencing for Minimal Residual Disease Surveillance in Acute Lymphoblastic Leukemia: An Update

Cynthia  Reyes-Barron; W. Richard  Burack; Paul G.  Rothberg; Yi  Ding

doi:10.1615/CritRevOncog.2017020588

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总编辑: Benjamin Bonavida (open in a new tab)

每年出版 4 期

ISSN 打印: 0893-9675

ISSN 在线: 2162-6448

Indexed in

Next-Generation Sequencing for Minimal Residual Disease Surveillance in Acute Lymphoblastic Leukemia: An Update

卷 22, 册 5-6, 2017, pp. 559-567

DOI: 10.1615/CritRevOncog.2017020588

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Cynthia Reyes-Barron
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642

W. Richard Burack
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642

Paul G. Rothberg
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642

Yi Ding
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642

摘要

Monitoring minimal residual disease (MRD) is an important predictor of outcome in acute lymphoblastic leukemia (ALL) and is used in risk stratification, prognosis determination, and therapy guidance. Several laboratory techniques have proven utility for characterizing leukemic cells and following MRD through diagnosis, remission and possible recurrence. Methods for determining MRD are based on the detection of leukemia-specific aberrant immunophenotypes by mulitparameter flow cytometry or the evaluation of leukemia-specific rearranged immunoglobulin or T-cell receptor sequences by quantitative real-time PCR. Next-generation sequencing (NGS) is emerging as a new flexible and sensitive tool to detect MRD, which allows identification of clonal composition and scalable sensitivity depending on sequence coverage. As NGS becomes more accessible and affordable, guidelines should be established for its application to MRD surveillance.

键词: minimal residual disease, next generation sequencing, acute lymphoblastic leukemia

对本文的引用

Rastogi Pulkit, Sachdeva Man Updesh Singh, Flow Cytometric Minimal Residual Disease Analysis in Acute Leukemia: Current Status, Indian Journal of Hematology and Blood Transfusion, 36, 1, 2020. Crossref
Kim In-Suk, Minimal residual disease in acute lymphoblastic leukemia: technical aspects and implications for clinical interpretation, BLOOD RESEARCH, 55, S1, 2020. Crossref
Kovach Alexandra E., Raca Gordana, Bhojwani Deepa, Wood Brent L., Next-Generation Sequencing for Measurable Residual Disease Assessment in Acute Leukemia, Advances in Molecular Pathology, 4, 2021. Crossref
Ho Caleb, Rothberg Paul G., Next-Generation Sequencing–Based Antigen-Receptor Gene Clonality Assays, The Journal of Molecular Diagnostics, 23, 9, 2021. Crossref
Diamanti Paraskevi, Cox Charlotte V., Ede Benjamin C., Uger Robert A., Moppett John P., Blair Allison, Targeting pediatric leukemia-propagating cells with anti-CD200 antibody therapy, Blood Advances, 5, 18, 2021. Crossref
Zhang Xiaohui, Precursor Lymphoid Neoplasms, in Practical Oncologic Molecular Pathology, 2021. Crossref

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