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ISSN 打印: 0893-9675

ISSN 在线: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Epithelial-to-Mesenchymal Transition: Liaison between Cancer Metastasis and Drug Resistance

卷 22, 册 3-4, 2017, pp. 275-282
DOI: 10.1615/CritRevOncog.2018024855
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摘要

Metastasis and drug resistance are two of the leading causes of death in cancer patients. Poor responses to antitumor drugs can lead to tumor cell dissemination and metastasis. On the other hand, cells that metastasize to lymph nodes and distant organs are liable to drug resistance. Recently, the epithelial–mesenchymal transition (EMT) has been found to play a critical role in cancer metastasis and drug resistance; however, the underlying and intrinsic links between them remain unclear. In this review, we summarize recent advances in tumor metastasis and drug resistance, and we focus especially on the association between EMT, metastasis, and drug resistance. We discuss the molecular mechanisms and potential pathways involved in the regulation of EMT, focusing simultaneously on the roles of EMT in modulating metastasis and drug resistance, especially the nature of their intrinsic links across different types of cancer.

对本文的引用
  1. Zeng , Pöttler , Lan , Grützmann , Pilarsky , Yang , Chemoresistance in Pancreatic Cancer, International Journal of Molecular Sciences, 20, 18, 2019. Crossref

  2. Dzobo Kevin, Thomford Nicholas Ekow, Senthebane Dimakatso A., Targeting the Versatile Wnt/β-Catenin Pathway in Cancer Biology and Therapeutics: From Concept to Actionable Strategy, OMICS: A Journal of Integrative Biology, 23, 11, 2019. Crossref

  3. Girolami Ilaria, Veronese Nicola, Smith Lee, Caruso Maria G., Reddavide Rosa, Leandro Gioacchino, Demurtas Jacopo, Nottegar Alessia, The Activation Status of the TGF-β Transducer Smad2 Is Associated with a Reduced Survival in Gastrointestinal Cancers: A Systematic Review and Meta-Analysis, International Journal of Molecular Sciences, 20, 15, 2019. Crossref

  4. Mbaveng Armelle T., Chi Godloves F., Bonsou Idrios N., Abdelfatah Sara, Tamfu Alfred N., Yeboah Elisabeth M.O., Kuete Victor, Efferth Thomas, N-acetylglycoside of oleanolic acid (aridanin) displays promising cytotoxicity towards human and animal cancer cells, inducing apoptotic, ferroptotic and necroptotic cell death, Phytomedicine, 76, 2020. Crossref

  5. Wang Qi, Cao Tianyu, Guo Kai, Zhou Yao, Liu Hao, Pan Yanan, Hou Qiuqiu, Nie Yongzhan, Fan Daiming, Lu Yuanyuan, Zhao Xiaodi, Regulation of Integrin Subunit Alpha 2 by miR-135b-5p Modulates Chemoresistance in Gastric Cancer, Frontiers in Oncology, 10, 2020. Crossref

  6. Regmi Prabha, Lai Kuo-Chu, Liu Chung-Ji, Lee Te-Chang, SAHA Overcomes 5-FU Resistance in IFIT2-Depleted Oral Squamous Cell Carcinoma Cells, Cancers, 12, 12, 2020. Crossref

  7. Kumar Pankaj, Siripini Satish, Sreedhar Amere Subbarao, The matrix metalloproteinase 7 ( MMP7 ) links Hsp90 chaperone with acquired drug resistance and tumor metastasis , Cancer Reports, 2020. Crossref

  8. Cao Lei, Zhu Yuqin, Wang Weiju, Wang Gaoxiong, Zhang Shuaishuai, Cheng Hongwei, Emerging Nano-Based Strategies Against Drug Resistance in Tumor Chemotherapy, Frontiers in Bioengineering and Biotechnology, 9, 2021. Crossref

  9. Zhao Jinzhu, Li Leilei, Wang Zhijia, Li Linlin, He Mingjing, Han Shuhua, Dong Yalong, Liu Xiaojie, Zhao Wen, Ke Yu, Wang Cong, Luteolin attenuates cancer cell stemness in PTX-resistant oesophageal cancer cells through mediating SOX2 protein stability, Pharmacological Research, 174, 2021. Crossref

  10. Pienta K.J., Hammarlund E.U., Austin R.H., Axelrod R., Brown J.S., Amend S.R., Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy, Seminars in Cancer Biology, 81, 2022. Crossref

  11. Pienta K. J., Hammarlund E. U., Brown J. S., Amend S. R., Axelrod R. M., Cancer recurrence and lethality are enabled by enhanced survival and reversible cell cycle arrest of polyaneuploid cells, Proceedings of the National Academy of Sciences, 118, 7, 2021. Crossref

  12. Pienta Kenneth J., Hammarlund Emma U., Axelrod Robert, Amend Sarah R., Brown Joel S., Convergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer, Molecular Cancer Research, 18, 6, 2020. Crossref

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