每年出版 4 期
ISSN 打印: 1947-5764
ISSN 在线: 1947-5772
Indexed in
Electromagnetic Fields Induce Frequency-Dependent Radioprotection and Radiosensitization in In Vitro Cell Cultures
摘要
The incidence of Kaposi sarcoma comorbidity in patients with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is high. These patients tend to be more sensitive to ionizing radiation, making the management of their cancer with radiotherapy difficult. Hence, noninvasive methods to sensitize cancer cells and reduce therapeutic doses are needed. In this article, the effect of an electromagnetic field (EMF) of 27.125 MHz, modulated by 100- and 1000-Hz fields, on the radiosensitivity of Chinese hamster lung fibroblasts (V79) and human melanoma cells (MeWo) was evaluated using the colony-forming assay. Induced magnetic flux densities in cell cultures ranged from 0.05 to 0.25 μT. Preexposure of V79 to both modulated fields had no effect on their radiosensitivity, if irradiation followed within 2 h or at 6 h. Significant radiosensitization was observed when X-rays were administered 4 h after EMF exposure. Preexposure of MeWo to the 100-Hz-modulated field resulted in a significant radioprotection when irradiation followed within 6 h. However, treatment of these cells with the 1000-Hz-modulated field significantly potentiated the effect of X-rays. When cells were irradiated before EMF exposure, V79 cells were marginally protected by the 100-Hz-modulated field and sensitized by the 1000-Hz-modulated field. In contrast, the melanoma cells were slightly protected by the 1000-Hz-modulated field and sensitized by the 100-Hz-modulated field. Informed combination of low-medium frequency electromagnetic fields and radiotherapy might be beneficial in cancer management, especially in HIV-positive patients.
-
Chinhengo Angela , Serafin Antonio M., Akudugu John, Radiosensitization by Low-Frequency Radiofrequency Fields is Dependent on the Magnitude of the Modulating Frequency , Plasma Medicine, 12, 2, 2022. Crossref