每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
Space Flight: A Challenge for Normal Bone Homeostasis
摘要
Space flight results in loss of bone mass, especially in weight-bearing bones, a condition that is suggested to be similar to disuse osteoporosis. As models to elucidate the underlying mechanism, bed rest studies were performed and bone metabolism in the rat both during space flight and during hindlimb unloading was investigated. The general picture is that bone formation is decreased partly as a result of reduced osteoblast function, whereas bone resorption is unaltered or increased. This deficit in bone mass can be replaced, but the time span for restoration exceeds the period of unloading. Changes in blood flow, systemic hormones, and locally produced factors are contributing in a yet undefined way to the response of osteoblastic cells to loading. The pathway by which loading and/or gravity are transduced into biochemical signals is still unknown. In vitro studies with osteoblastic cells show that their differentiation and cell morphology are altered during space flight. Elucidation of the involved signaling pathways has only recently been started. It is hoped that as the mechanisms by which bone responds to mechanical (un)loading are further understood, this insight will influence the treatment of other etiologies of osteoporosis.
-
Grimm Daniela, Wise Petra, Lebert Michael, Richter Peter, Baatout Sarah, How and why does the proteome respond to microgravity?, Expert Review of Proteomics, 8, 1, 2011. Crossref
-
Monici Monica, Fusi Franco, Paglierani Milena, Marziliano Nicola, Cogoli Augusto, Pratesi Riccardo, Bernabei Pietro Antonio, Modeled gravitational unloading triggers differentiation and apoptosis in preosteoclastic cells, Journal of Cellular Biochemistry, 98, 1, 2006. Crossref
-
Hofstetter John, Suckow Mark A., Hickman Debra L., Morphophysiology, in The Laboratory Rat, 2006. Crossref
-
Hu L.F., Qian A.R., Wang Y., Di S.M., Shang P., Inhibitory effect of simulated microgravity on differentiating preosteoblasts, Advances in Space Research, 51, 1, 2013. Crossref
-
Yano Sachiko, Kitamura Kei-ichiro, Satoh Yusuke, Nakano Masaki, Hattori Atsuhiko, Sekiguchi Toshio, Ikegame Mika, Nakashima Hiroshi, Omori Katsunori, Hayakawa Kazuichi, Chiba Atsuhiko, Sasayama Yuichi, Ejiri Sadakazu, Mikuni-Takagaki Yuko, Mishima Hiroyuki, Funahashi Hisayuki, Sakamoto Tatsuya, Suzuki Nobuo, Static and Dynamic Hypergravity Responses of Osteoblasts and Osteoclasts in Medaka Scales, Zoological Science, 30, 3, 2013. Crossref
-
Vignaux Guillaume, Besnard Stéphane, Ndong Jean, Philoxène Bruno, Denise Pierre, Elefteriou Florent, Bone remodeling is regulated by inner ear vestibular signals, Journal of Bone and Mineral Research, 28, 10, 2013. Crossref
-
Shwartz Yulia, Blitz Einat, Zelzer Elazar, One load to rule them all: Mechanical control of the musculoskeletal system in development and aging, Differentiation, 86, 3, 2013. Crossref
-
Graebe Annemarie, Schuck Edgar L., Lensing Petra, Putcha Lakshmi, Derendorf Hartmut, Physiological, Pharmacokinetic, and Pharmacodynamic Changes in Space, The Journal of Clinical Pharmacology, 44, 8, 2004. Crossref
-
Grimm Daniela, Bauer Johann, Infanger Manfred, Cogoli Augusto, The use of the random positioning machine for the study of gravitational effects on signal transduction in mammalian cells, Signal Transduction, 6, 6, 2006. Crossref
-
Manolagas Stavros C., O'Brien Charles A., Almeida Maria, The role of estrogen and androgen receptors in bone health and disease, Nature Reviews Endocrinology, 9, 12, 2013. Crossref
-
Su Min, Jiang Hui, Zhang Ping, Liu Yunlong, Wang Exing, Hsu Andrew, Yokota Hiroki, Knee-Loading Modality Drives Molecular Transport in Mouse Femur, Annals of Biomedical Engineering, 34, 10, 2006. Crossref
-
SHANG PENG, ZHANG JIAN, QIAN AIRONG, LI JINGBAO, MENG RUI, DI SHENGMENG, HU LIFANG, GU ZHONGZE, BONE CELLS UNDER MICROGRAVITY, Journal of Mechanics in Medicine and Biology, 13, 05, 2013. Crossref
-
Moes Maarten J. A., Gielen Jeroen C., Bleichrodt Robert-Jan, van Loon Jack J. W. A., Christianen Peter C. M., Boonstra Johannes, Simulation of Microgravity by Magnetic Levitation and Random Positioning: Effect on Human A431 Cell Morphology, Microgravity Science and Technology, 23, 2, 2011. Crossref
-
Manti Lorenzo, Does reduced gravity alter cellular response to ionizing radiation?, Radiation and Environmental Biophysics, 45, 1, 2006. Crossref
-
Aguirre J Ignacio, Plotkin Lilian I, Stewart Scott A, Weinstein Robert S, Parfitt A Michael, Manolagas Stavros C, Bellido Teresita, Osteocyte Apoptosis Is Induced by Weightlessness in Mice and Precedes Osteoclast Recruitment and Bone Loss, Journal of Bone and Mineral Research, 21, 4, 2006. Crossref
-
Basile Venere, Romano Giovanni, Fusi Franco, Monici Monica, Comparison Between the Effects of Hypergravity and Photomechanical Stress on Cells Producing ECM, Microgravity Science and Technology, 21, 1-2, 2009. Crossref
-
Sun Lian Wen, Wang Chao, Pu Fang, Li De Yu, Niu Hai Jun, Fan Yu Bo, Comparative Study on Measured Variables and Sensitivity to Bone Microstructural Changes Induced by Weightlessness Between In Vivo and Ex Vivo Micro-CT Scans, Calcified Tissue International, 88, 1, 2011. Crossref
-
Renn J., Seibt D., Goerlich R., Schartl M., Winkler C., Simulated microgravity upregulates gene expression of the skeletal regulator Core binding Factor α1/Runx2 in Medaka fish larvae in vivo, Advances in Space Research, 38, 6, 2006. Crossref
-
Beckers Frank, Verheyden Bart, Aubert André E., Space Physiology, in Wiley Encyclopedia of Biomedical Engineering, 2006. Crossref
-
Arai Koji Y., Sugimoto Mami, Ito Kanako, Ogura Yuki, Akutsu Nobuko, Amano Satoshi, Adachi Eijiro, Nishiyama Toshio, Repeated folding stress-induced morphological changes in the dermal equivalent, Skin Research and Technology, 20, 4, 2014. Crossref
-
Li Chai-Fei, Hughes-Fulford Millie, Fibroblast Growth Factor-2 Is an Immediate-Early Gene Induced by Mechanical Stress in Osteogenic Cells, Journal of Bone and Mineral Research, 21, 6, 2006. Crossref
-
Chen Jun, Liu Rongrong, Yang Yang, Li Jing, Zhang Xiaofeng, Li Junchang, Wang Zongren, Ma Jing, The simulated microgravity enhances the differentiation of mesenchymal stem cells into neurons, Neuroscience Letters, 505, 2, 2011. Crossref
-
Harvey Kristin B., Donahue Seth W., Bending properties, porosity, and ash fraction of black bear (Ursus americanus) cortical bone are not compromised with aging despite annual periods of disuse, Journal of Biomechanics, 37, 10, 2004. Crossref
-
Hu Li-fang, Li Jing-bao, Qian Ai-rong, Wang Fei, Shang Peng, Mineralization initiation of MC3T3-E1 preosteoblast is suppressed under simulated microgravity condition, Cell Biology International, 39, 4, 2015. Crossref
-
Monici Monica, Bernabei Pietro Antonio, Basile Venere, Romano Giovanni, Conti Antonio, Breschi Luca, Masotti Leonardo, Cogoli Augusto, Can ultrasound counteract bone loss? Effect of low-intensity ultrasound stimulation on a model of osteoclastic precursor, Acta Astronautica, 60, 4-7, 2007. Crossref
-
Thompson William R., Rubin Clinton T., Rubin Janet, Mechanical regulation of signaling pathways in bone, Gene, 503, 2, 2012. Crossref
-
Sun Lian-wen, Fan Yu-bo, Li De-yu, Zhao Feng, Xie Tian, Yang Xiao, Gu Zhang-ting, Evaluation of the mechanical properties of rat bone under simulated microgravity using nanoindentation, Acta Biomaterialia, 5, 9, 2009. Crossref
-
Lu Ying, Zheng Qinghua, Lu Wanlu, Yue Junli, Zhou Wei, Zhou Xuedong, Zhang Lan, Huang Dingming, Compressive mechanical stress may activate IKK-NF-κB through proinflammatory cytokines in MC3T3-E1 cells, Biotechnology Letters, 37, 9, 2015. Crossref
-
Zhang Ping, Hamamura Kazunori, Yokota Hiroki, A Brief Review of Bone Adaptation to Unloading, Genomics, Proteomics & Bioinformatics, 6, 1, 2008. Crossref
-
Rubin Janet, Rubin Clinton, Jacobs Christopher Rae, Molecular pathways mediating mechanical signaling in bone, Gene, 367, 2006. Crossref
-
Narayanan R, Smith C.L, Weigel N.L, Vector-averaged gravity-induced changes in cell signaling and vitamin d receptor activity in MG-63 cells are reversed by a 1,25-(OH)2D3 analog, EB1089, Bone, 31, 3, 2002. Crossref
-
Sun Lianwen, Gan Bo, Fan Yubo, Xie Tian, Hu Qinghua, Zhuang Fengyuan, Simulated microgravity alters multipotential differentiation of rat mesenchymal stem cells in association with reduced telomerase activity, Acta Astronautica, 63, 7-10, 2008. Crossref
-
Shuang Feng, Sun Yu, Yang Huai-He, Shao Yin-Chu, Li Hao, Hu Wei, Zhong Jun, Zou Hong-Xing, Destrin deletion enhances the bone loss in hindlimb suspended mice, European Journal of Applied Physiology, 113, 2, 2013. Crossref
-
Suzuki N., Kitamura K., Nemoto T., Shimizu N., Wada S., Kondo T., Tabata M.J., Sodeyama F., Ijiri K., Hattori A., Effect of vibration on osteoblastic and osteoclastic activities: Analysis of bone metabolism using goldfish scale as a model for bone, Advances in Space Research, 40, 11, 2007. Crossref
-
Manolagas Stavros C, Choreography from the tomb: An emerging role of dying osteocytes in the purposeful, and perhaps not so purposeful, targeting of bone remodeling, BoneKEy-Osteovision, 3, 1, 2006. Crossref
-
Torday J.S., Parathyroid hormone-related protein is a gravisensor in lung and bone cell biology, Advances in Space Research, 32, 8, 2003. Crossref
-
Wagner T.U., Renn J., Riemensperger T., Volff J.-N., Köster R.W., Goerlich R., Schartl M., Winkler C., The teleost fish medaka (Oryzias latipes) as genetic model to study gravity dependent bone homeostasis in vivo, Advances in Space Research, 32, 8, 2003. Crossref
-
Albi Elisabetta, Curcio Francesco, Spelat Renza, Lazzarini Andrea, Lazzarini Remo, Cataldi Samuela, Loreti Elisabetta, Ferri Ivana, Ambesi-Impiombato Francesco Saverio, He Bin, Loss of Parafollicular Cells during Gravitational Changes (Microgravity, Hypergravity) and the Secret Effect of Pleiotrophin, PLoS ONE, 7, 12, 2012. Crossref
-
Grimm Daniela, Grosse Jirka, Wehland Markus, Mann Vivek, Reseland Janne Elin, Sundaresan Alamelu, Corydon Thomas Juhl, The impact of microgravity on bone in humans, Bone, 87, 2016. Crossref
-
Aceto Jessica, Nourizadeh-Lillabadi Rasoul, Bradamante Silvia, Maier Jeanette A, Alestrom Peter, van Loon Jack JWA, Muller Marc, Effects of microgravity simulation on zebrafish transcriptomes and bone physiology—exposure starting at 5 days post fertilization, npj Microgravity, 2, 1, 2016. Crossref
-
Yang Lianxiang, Zhang Ping, Liu Sheng, Samala Praveen R., Su Min, Yokota Hiroki, Measurement of strain distributions in mouse femora with 3D-digital speckle pattern interferometry, Optics and Lasers in Engineering, 45, 8, 2007. Crossref
-
Chiquet Matthias, Tunç-Civelek Vildan, Sarasa-Renedo Ana, Gene regulation by mechanotransduction in fibroblasts, Applied Physiology, Nutrition, and Metabolism, 32, 5, 2007. Crossref
-
MATSUDA Junpei, KURATA Kosaku, FUKUNAGA Takanobu, HIGAKI Hidehiko, Mechanical Response of Osteocyte to Multi-Dimensional Gravity, Biomechanisms, 18, 2006. Crossref
-
ZHENG LI-HUA, CAI FENG-FENG, GE ISABELL, BISKUP EWELINA, CHENG ZHONG-PING, Stromal fibroblast activation and their potential association with uterine fibroids (Review), Oncology Letters, 8, 2, 2014. Crossref
-
Diao Yan, Chen Bin, Wei Lijun, Wang Zhenyu, Polyphenols (S3) Isolated from Cone Scales of Pinus koraiensis Alleviate Decreased Bone Formation in Rat under Simulated Microgravity, Scientific Reports, 8, 1, 2018. Crossref
-
Naito Kaoru, Matsuzaka Kenichi, Ishigami Keiichi, Inoue Takashi, Mechanical force promotes proliferation and early differentiation of bone marrow derived osteoblast-like cells in vitro, Oral Medicine & Pathology, 13, 4, 2009. Crossref
-
Heer Martina, Baecker Natalie, Smith Scott M., Swart Sara R., Nutritional Countermeasures for Spaceflight-Related Stress, in Stress Challenges and Immunity in Space, 2012. Crossref
-
Suzuki Nobuo, Omori Katsunori, Nakamura Masahisa, Tabata Makoto J., Ikegame Mika, Ijiri Kenichi, Kitamura Kei-Ichiro, Nemoto Tetsu, Shimizu Nobuaki, Kondo Takashi, Matsuda Kouhei, Ando Hironori, Kasahara Haruo, Nagase Mutsumu, Nara Masayuki, Hattori Atsuhiko, Scale osteoblasts and osteoclasts sensitively respond to low-gravity loading by centrifuge, Biological Sciences in Space, 22, 1, 2008. Crossref
-
Fong Kevin, Human spaceflight in the UK: the cost of non-participation, Earth, Moon, and Planets, 94, 3-4, 2005. Crossref
-
Niisato Naomi, Marunaka Yoshinori, Sensing Mechanism of Stretch Activated Ion Channels, in Mechanically Gated Channels and their Regulation, 2012. Crossref
-
Yamamoto Kenta, Yamamoto Toshiro, Kanamura Narisato, Kita Masakaz, Role of mechanical stress in mandible bone metabolism, Inflammation and Regeneration, 32, 3, 2012. Crossref
-
Kitamura Kei-ichiro, Chen Wenxi, Zhu Xin, Suzuki Nobuo, Yano Sachiko, Nemoto Tetsu, Acceleration-Based Study of Optimum Exercise for Human Weight-Bearing Bones Enhancement, Biological Sciences in Space, 24, 2, 2010. Crossref
-
Suzuki Nobuo, Kitamura Kei-Ichiro, Omori Katsunori, Nemoto Tetsu, Satoh Yusuke, J. Tabata Makoto, Ikegame Mika, Yamamoto Toshio, Ijiri Kenichi, Furusawa Yukihiro, Kondo Takashi, Takasaki Ichiro, Tabuchi Yoshiaki, Wada Shigehito, Shimizu Nobuaki, Sasayama Yuichi, Endo Masato, Takeuchi Toshio, Nara Masayuki, Somei Masanori, Maruyama Yusuke, Hayakawa Kazuichi, Shimazu Toru, Shigeto Yuko, Yano Sachiko, Hattori Atsuhiko, Response of osteoblasts and osteoclasts in regenerating scales to gravity loading, Biological Sciences in Space, 23, 4, 2009. Crossref
-
Pitsillides Andrew A., Rawlinson Simon C. F., Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation, in Bone Research Protocols, 816, 2012. Crossref
-
Kong Lingbo, Wang Youhan, Smith Wanli, Hao Dingjun, Macrophages in Bone Homeostasis, Current Stem Cell Research & Therapy, 14, 6, 2019. Crossref
-
Heer Martina, Titze Jens, Smith Scott M., Baecker Natalie, Minerals, in Nutrition Physiology and Metabolism in Spaceflight and Analog Studies, 2015. Crossref
-
Yang L. X., Yokota H., Recent Developments of Speckle Pattern Interferometer for Bone Strain Measurement, in Experimental Analysis of Nano and Engineering Materials and Structures, 2007. Crossref
-
Dadwal Ushashi C., Maupin Kevin A., Zamarioli Ariane, Tucker Aamir, Harris Jonathan S., Fischer James P., Rytlewski Jeffery D., Scofield David C., Wininger Austin E., Bhatti Fazal Ur Rehman, Alvarez Marta, Childress Paul J., Chakraborty Nabarun, Gautam Aarti, Hammamieh Rasha, Kacena Melissa A., The effects of spaceflight and fracture healing on distant skeletal sites, Scientific Reports, 9, 1, 2019. Crossref
-
Sun Weijia, Chi Shaopeng, Li Yuheng, Ling Shukuan, Tan Yingjun, Xu Youjia, Jiang Fan, Li Jianwei, Liu Caizhi, Zhong Guohui, Cao Dengchao, Jin Xiaoyan, Zhao Dingsheng, Gao Xingcheng, Liu Zizhong, Xiao Bailong, Li Yingxian, The mechanosensitive Piezo1 channel is required for bone formation, eLife, 8, 2019. Crossref
-
Fitzgerald Jamie, Endicott Jamie, Hansen Uwe, Janowitz Cathleen, Articular cartilage and sternal fibrocartilage respond differently to extended microgravity, npj Microgravity, 5, 1, 2019. Crossref
-
Semov Alexandre, Semova Nathalia, Lacelle Chantale, Marcotte Richard, Petroulakis Emmanuel, Proestou Gregory, Wang Eugenia, Alterations in TNF‐ and IL‐related gene expression in space‐flown WI38 human fibroblasts, The FASEB Journal, 16, 8, 2002. Crossref
-
Du Trina Y., Standen Emily M., Terrestrial acclimation and exercise lead to bone functional response in Polypterus pectoral fins, Journal of Experimental Biology, 2020. Crossref
-
Alzghoul Mohammed Borhan, Gerrard Dave, Watkins Bruce A., Hannon Kevin, Ectopic expression of IGF‐I and Shh by skeletal muscle inhibits disuse‐mediated skeletal muscle atrophy and bone osteopenia in vivo, The FASEB Journal, 18, 1, 2004. Crossref
-
Zhivodernikov Ivan, Ratushnyy Andrey, Buravkova Ludmila, Simulated Microgravity Remodels Extracellular Matrix of Osteocommitted Mesenchymal Stromal Cells, International Journal of Molecular Sciences, 22, 11, 2021. Crossref
-
Qiao Yini, Wang Yang, Zhou Yimei, Jiang Fulin, Huang Tu, Chen Liujing, Lan Jingxiang, Yang Cai, Guo Yutong, Yan Shanyu, Wei Zhangming, Li Juan, The role of nervous system in adaptive response of bone to mechanical loading, Journal of Cellular Physiology, 234, 6, 2019. Crossref
-
Littner Yoav, Mandel Dror, Mimouni Francis B, Dollberg Shaul, Decreased Bone Ultrasound Velocity in Large-for-Gestational-Age Infants, Journal of Perinatology, 24, 1, 2004. Crossref
-
Choi Yun-Kyong, Cho Hyunjin, Seo Young-Kwon, Yoon Hee-Hoon, Park Jung-Keug, Stimulation of sub-sonic vibration promotes the differentiation of adipose tissue-derived mesenchymal stem cells into neural cells, Life Sciences, 91, 9-10, 2012. Crossref
-
Yamamoto Tatsuki, Ikegame Mika, Furusawa Yukihiro, Tabuchi Yoshiaki, Hatano Kaito, Watanabe Kazuki, Kawago Umi, Hirayama Jun, Yano Sachiko, Sekiguchi Toshio, Kitamura Kei-ichiro, Endo Masato, Nagami Arata, Matsubara Hajime, Maruyama Yusuke, Hattori Atsuhiko, Suzuki Nobuo, Osteoclastic and Osteoblastic Responses to Hypergravity and Microgravity: Analysis Using Goldfish Scales as a Bone Model, Zoological Science, 39, 4, 2022. Crossref
-
Baran Ronni, Wehland Markus, Schulz Herbert, Heer Martina, Infanger Manfred, Grimm Daniela, Microgravity-Related Changes in Bone Density and Treatment Options: A Systematic Review, International Journal of Molecular Sciences, 23, 15, 2022. Crossref