每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
Signaling Pathways in Pancreatic Cancer
摘要
Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by a plethora of molecular alterations that include major and minor driving mutations, the presence of intense desmoplasia exhibiting numerous proliferating pancreatic stellate cells (PSC) and cancer-associated fibroblasts that produce fibronectin and collagens, and foci of inflammatory cells that produce mitogenic cytokines. This review will focus on signaling by tyrosine kinase receptors, and the role of transforming growth factor beta in this malignancy is described briefly. Potential for therapeutic interventions will be discussed in relation to specific pathways.
-
Lee Linda S., Bellizzi Andrew M., Banks Peter A., Sainani Nisha I., Kadiyala Vivek, Suleiman Shadeah, Conwell Darwin L., Paulo Joao A., Differentiating Branch Duct and Mixed IPMN in Endoscopically Collected Pancreatic Cyst Fluid via Cytokine Analysis, Gastroenterology Research and Practice, 2012, 2012. Crossref
-
Kramer-Marek Gabriela, Gore Jesse, Korc Murray, Molecular imaging in pancreatic cancer – A roadmap for therapeutic decisions, Cancer Letters, 341, 2, 2013. Crossref
-
Ouyang H, Gore J, Deitz S, Korc M, microRNA-10b enhances pancreatic cancer cell invasion by suppressing TIP30 expression and promoting EGF and TGF-β actions, Oncogene, 33, 38, 2014. Crossref
-
Cote Gregory A, Gore Jesse A, McElyea Samantha D, Heathers Laura E, Xu Huiping, Sherman Stuart, Korc Murray, A Pilot Study to Develop a Diagnostic Test for Pancreatic Ductal Adenocarcinoma Based on Differential Expression of Select miRNA in Plasma and Bile, American Journal of Gastroenterology, 109, 12, 2014. Crossref
-
Silverman Richard B., Holladay Mark W., Receptors, in The Organic Chemistry of Drug Design and Drug Action, 2014. Crossref
-
Zhang Jianliang, He Di-Hua, Zajac-Kaye Maria, Hochwald Steven N, A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells, Cell Cycle, 13, 19, 2014. Crossref
-
Mrsny R., Cancer cell biology, in Biomaterials for Cancer Therapeutics, 2013. Crossref
-
Han Bumsoo, Qu Chunjing, Park Kinam, Konieczny Stephen F., Korc Murray, Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip, Cancer Letters, 380, 1, 2016. Crossref
-
Kleeff Jorg, Korc Murray, Apte Minoti, La Vecchia Carlo, Johnson Colin D., Biankin Andrew V., Neale Rachel E., Tempero Margaret, Tuveson David A., Hruban Ralph H., Neoptolemos John P., Pancreatic cancer, Nature Reviews Disease Primers, 2, 1, 2016. Crossref
-
Korc Murray, Smad4-TGF-β Signaling Pathways in Pancreatic Cancer Pathogenesis, in Pancreatic Cancer, 2017. Crossref
-
Tian Xiao-Feng, Huang Guo-Min, Zang Hong-Liang, Cao Hong, PACE4 regulates apoptosis in human pancreatic cancer Panc-1 cells via the mitochondrial signaling pathway, Molecular Medicine Reports, 14, 6, 2016. Crossref
-
WU YUAN-YUAN, MA TIE-LIANG, GE ZHI-JUN, LIN JIE, DING WEI-LIANG, FENG JIA-KE, ZHOU SU-JUN, CHEN GUO-CHANG, TAN YONG-FEI, CUI GUO-XING, JWA gene regulates PANC-1 pancreatic cancer cell behaviors through MEK-ERK1/2 of the MAPK signaling pathway, Oncology Letters, 8, 4, 2014. Crossref
-
Lin Chien-Chi, Korc Murray, Designer hydrogels: Shedding light on the physical chemistry of the pancreatic cancer microenvironment, Cancer Letters, 436, 2018. Crossref
-
Korc Murray, Smad4-TGF-β Signaling Pathways in Pancreatic Cancer Pathogenesis, in Pancreatic Cancer, 2018. Crossref
-
Gong Liuyun, Zhang Dan, Lei Yutiantian, Qian Yuanjie, Tan Xinyue, Han Suxia, Transcriptome-wide association study identifies multiple genes and pathways associated with pancreatic cancer, Cancer Medicine, 7, 11, 2018. Crossref
-
Li Quanxiao, Yang Gang, Feng Mengyu, Zheng Suli, Cao Zhe, Qiu Jiangdong, You Lei, Zheng Lianfang, Hu Ya, Zhang Taiping, Zhao Yupei, NF-κB in pancreatic cancer: Its key role in chemoresistance, Cancer Letters, 421, 2018. Crossref
-
Prabhu Lakshmi, Mundade Rasika, Korc Murray, Loehrer Patrick J., Lu Tao, Critical role of NF-κB in pancreatic cancer, Oncotarget, 5, 22, 2014. Crossref
-
Cravo Ana Santos, Mrsny Randall, Cancer: so common and so difficult to deal with, in Biomaterials for Cancer Therapeutics, 2020. Crossref
-
Bradney Michael J., Venis Stephanie M., Yang Yi, Konieczny Stephen F., Han Bumsoo, A Biomimetic Tumor Model of Heterogeneous Invasion in Pancreatic Ductal Adenocarcinoma, Small, 16, 10, 2020. Crossref
-
Chou Che‐Yi, Chang Chiz‐Tzung, Chen Chao‐Jung, Analytically validated protein biomarkers of chronic pancreatitis and pancreatic cancer for potential clinical diagnosis with mass spectrometry, Rapid Communications in Mass Spectrometry, 34, S1, 2020. Crossref
-
Moon Hye-ran, Han Bumsoo, Engineered tumor models for cancer biology and treatment, in Biomaterials for Cancer Therapeutics, 2020. Crossref
-
Caston Rachel A., Shah Fenil, Starcher Colton L., Wireman Randall, Babb Olivia, Grimard Michelle, McGeown Jack, Armstrong Lee, Tong Yan, Pili Roberto, Rupert Joseph, Zimmers Teresa A., Elmi Adily N., Pollok Karen E., Motea Edward A., Kelley Mark R., Fishel Melissa L., Combined inhibition of Ref‐1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co‐culture models, Journal of Cellular and Molecular Medicine, 25, 2, 2021. Crossref
-
Hafezi Shirin, Saber-Ayad Maha, Abdel-Rahman Wael M., Highlights on the Role of KRAS Mutations in Reshaping the Microenvironment of Pancreatic Adenocarcinoma, International Journal of Molecular Sciences, 22, 19, 2021. Crossref
-
Makar Subhajit, Ghosh Abhrajyoti, Divya , Shivhare Shalini, Kumar Ashok, Singh Sushil K., Molecular Processes Involved in Pancreatic Cancer and Therapeutics, Current Chemical Biology, 15, 1, 2021. Crossref
-
Slee Roger B., Grimes Brenda R., Bansal Ruchi, Gore Jesse, Blackburn Corinne, Brown Lyndsey, Gasaway Rachel, Jeong Jaesik, Victorino Jose, March Keith L., Colombo Riccardo, Herbert Brittney-Shea, Korc Murray, Selective Inhibition of Pancreatic Ductal Adenocarcinoma Cell Growth by the Mitotic MPS1 Kinase Inhibitor NMS-P715, Molecular Cancer Therapeutics, 13, 2, 2014. Crossref
-
Incio Joao, Liu Hao, Suboj Priya, Chin Shan M., Chen Ivy X., Pinter Matthias, Ng Mei R., Nia Hadi T., Grahovac Jelena, Kao Shannon, Babykutty Suboj, Huang Yuhui, Jung Keehoon, Rahbari Nuh N., Han Xiaoxing, Chauhan Vikash P., Martin John D., Kahn Julia, Huang Peigen, Desphande Vikram, Michaelson James, Michelakos Theodoros P., Ferrone Cristina R., Soares Raquel, Boucher Yves, Fukumura Dai, Jain Rakesh K., Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy, Cancer Discovery, 6, 8, 2016. Crossref
-
Nweke Ekene , Ntwasa Monde , Brand Martin , Devar John , Smith Martin , Candy Geoffrey , Increased expression of plakoglobin is associated with upregulated MAPK and PI3K/AKT signalling pathways in early resectable pancreatic ductal adenocarcinoma, Oncology Letters, 2020. Crossref
-
Fu Xiaoxue, Zhou Yi, Identifying Clinical Detection in Disease Context by Computational Mining of PubMed, Journal of Physics: Conference Series, 1865, 4, 2021. Crossref
-
Kunnimalaiyaan Selvi, Trevino Jose, Tsai Susan, Gamblin T. Clark, Kunnimalaiyaan Muthusamy, Xanthohumol-Mediated Suppression of Notch1 Signaling Is Associated with Antitumor Activity in Human Pancreatic Cancer Cells, Molecular Cancer Therapeutics, 14, 6, 2015. Crossref