摘要

Background: The principles of ethics are the aspiration goals of any profession. While planning a regenerative study, various ethical issues must be addressed from its conception to its execution and throughout the assessment of results.
Methods: Twenty interproximal intrabony two-walled defects in healthy nonsmoking patients with chronic periodontitis were randomly divided into a control group (Group 1: Periosteum alone) and an experimental group (Group 2: Periosteum with Alloplastic graft material). Measurements of probing pocket depth (PD) and clinical attachment levels (CAL) and radiographic bone defect area (BDA) were performed at baseline and at 6 months post surgery. Ethical issues were considered during enrollment, allocation of treatment, follow-up, and analysis of results.
Results: The results were affirmed according to the five parameters of ADA: patient autonomy, nonmaleficence, beneficence, justice, and veracity. The 6-month post operative assessments showed clinical and radiographic improvements with PD reduction, CAL gain, and changes in BDA in both the groups, which was statistically significant compared to the baseline (p<0.05). However, BDA reduction was statistically greater in Group 2 (48.88 ± 18.61%) compared to Group 1 (14.08 ± 12.97%) at the 6-month follow-up; (p=0.009).
Conclusion: Principles of ethics provide guidance and offer justification for the code of professional conduct and for advisory opinions regarding regenerative studies.