每年出版 12 期
ISSN 打印: 1521-9437
ISSN 在线: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
Antimelanomic Effects of High- and Low-Molecular Weight Bioactive Subfractions Isolated from the Mossy Maze Mushroom, Cerrena unicolor (Agaricomycetes)
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摘要
Three bioactive fractions isolated from Cerrena unicolor cultures−crude endopolysaccharide (c-EPS), laccase, and a subfraction of low-molecular weight secondary metabolites−were used to determine potential cytotoxic effects on the mouse melanoma B16-F10 cell line (American Type Culture Collection CRL-6475). The results obtained prove that all examined fractions exhibited activity against the investigated tumor cells. In addition, an evident immunomodulatory effect of the c-EPS fraction was observed. Our results show that the levels of 2 cytokines (tumor necrosis factor-a and chemokine ligand 2) in mouse inner medullary collecting duct mIMCD-3 cells (American Type Culture Collection CRL-2123) stimulated by c-EPS were significantly higher. A lipopolysaccharide model was used at the same concentration (10 μg/mL) as a positive control.
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Matuszewska Anna, Jaszek Magdalena, Stefaniuk Dawid, Ciszewski Tomasz, Matuszewski Łukasz, Caruso Calogero, Anticancer, antioxidant, and antibacterial activities of low molecular weight bioactive subfractions isolated from cultures of wood degrading fungus Cerrena unicolor, PLOS ONE, 13, 6, 2018. Crossref
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Matuszewska Anna, Stefaniuk Dawid, Jaszek Magdalena, Pięt Mateusz, Zając Adrian, Matuszewski Łukasz, Cios Iga, Grąz Marcin, Paduch Roman, Bancerz Renata, Antitumor potential of new low molecular weight antioxidative preparations from the white rot fungus Cerrena unicolor against human colon cancer cells, Scientific Reports, 9, 1, 2019. Crossref
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Wagner Grzegorz Karol, Jaszek Magdalena, Staniec Bernard, Prendecka Monika, Pigoń Dominika, Belcarz Anna, Stefaniuk Dawid, Matuszewska Anna, Pietrykowska-Tudruj Ewa, Zagaja Mirosław, Lasius fuliginosus Nest Carton as a Source of New Promising Bioactive Extracts with Chemopreventive Potential, International Journal of Molecular Sciences, 22, 9, 2021. Crossref
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Stefaniuk Dawid, Misztal Tomasz, Pięt Mateusz, Zając Adrian, Kopycińska Magdalena, Matuszewska Anna, Ruminowicz-Stefaniuk Marta, Matuszewski Łukasz, Marcińczyk Natalia, Belcarz Anna, Żuchowski Jerzy, Skrabalak Ilona, Grąz Marcin, Ciołek Beata, Paduch Roman, Jaszek Magdalena, Thromboelastometric Analysis of Anticancer Cerrena unicolor Subfractions Reveal Their Potential as Fibrin Glue Drug Carrier Enhancers, Biomolecules, 11, 9, 2021. Crossref
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Ziaja-Sołtys Marta, Kołodziej Przemysław, Stefaniuk Dawid, Matuszewska Anna, Jaszek Magdalena, Bogucka-Kocka Anna, Low-Molecular-Weight Secondary Metabolites from Fungi: Cerrena unicolor as a New Proposal of an Effective Preparation against Rhabditis Nematodes, Molecules, 27, 5, 2022. Crossref