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ISSN 打印: 1521-9437

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The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Pharmacological Studies on Certain Mushrooms from China

卷 3, 册 4, 2001, 14 pages
DOI: 10.1615/IntJMedMushr.v3.i4.60
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摘要

This article focuses mainly on biopharmacological studies of selected Chinese medicinal mushrooms, namely the immunomodulation and antitumor activity of Tricholoma giganteum Massee, blood pressure lowering action and mechanism of Volvariella volvacea (Bull.: Fr.) Sing., and the liver protective effect of Trametes versicolor (L.: Fr.) Lloyd. A polysaccharide-protein complex (PSPC) isolated from the culture filtrates of T. giganteum inhibited the growth of solid Sarcoma 180 in mice, with no sign of toxicity. PSPC showed immunomodulating action in vivo. It restored and increased phagocytic function of peritoneal exudate cells (macrophages) of the tumor-bearing mice. It also exhibited indirect cytotoxicity against P815 and L929 by activating macrophages to release the mediators, such as nitric oxide (NO) and tumor necrosis factor-α (TNF-α). The direct cytotoxicity of PSPC was observed in PU5-1.8, H3B, HL-60, and melanoma cell lines. The antiproliferative activity against PU5-1.8 cells was strong at a dose of 60 μg/ml of PSPC. Therefore, the antitumor activity of PSPC might be due to both host-mediated immunomodulating action and direct cytotoxicity to cancer cells. A fraction isolated from the fruiting bodies of Volvariella volvacea (VE), with a molecular mass of about 10 kDa, was heat stable and resistant to trypsin digestion. The blood pressure changes produced by the extract alone or in the presence of various specific agonists or antagonists were investigated. An intravenous injection of VE produced a hypotensive effect in normotensive rats with an ED50 of 25 mg dry weight/kg body weight. This hypotensive effect of VE was attenuated or blunted in the presence of hexamethonium, phentolamine, pyrilamine, and cimetidine suggesting the involvement of the α-adrenergic component of the autonomic system and/or histaminergic stimulation. The contractile response could be inhibited by the antagonists of serotonin and α-adrenoceptor, ketanserin, and phentolamine, respectively. It is likely that VE contained serotonin-like substances because the mechanism of action of VE was similar to that of serotonin. The protective effects of polysaccharide peptide (PSP) of Trametes versicolor on hepatotoxicity were investigated using carbon tetrachloride (CCl4)-induced and paracetamol (APAP)-induced liver injury in the rat as the chemical hepatitis models. A toxic dose of CCl4 (1.25 ml/kg) raised the levels of serum glutamic pyruvic transaminase (SGPT) and that of glutamic oxaloacetic transaminase (SGOT) in the experimental rats. PSP significantly reduced the elevated levels of both the SGPT and SGOT in rats exposed to CCl4. Similarly, a single oral dose of 1.0 g/kg of APAP was able to produce significantly elevated levels of SGPT and SGOT. Intraperitoneal administration of 300 mg/kg of PSP could significantly reduce the APAP-induced acute elevation in the levels of SGPT and SGOT in rats. PSP probably acts to prevent the fall of hepatic reduced glutathione (GSH) through some GSH-dependent enzymes and preserve the structural integrity of the cellular membrane of hepatocytes, or probably protect paracetamol-induced liver injury through their antioxidant properties acting as a scavenger of free radicals even at low levels of GSH.

对本文的引用
  1. Moradali Mohammad-Fata, Mostafavi Hossein, Ghods Shirin, Hedjaroude Ghorban-Ali, Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi), International Immunopharmacology, 7, 6, 2007. Crossref

  2. Ghosh Kaushik, Chandra Krishnendu, Roy Sadhan K., Mondal Subhas, Maiti Debabrata, Das Debsankar, Ojha Arnab K., Islam Syed S., Structural investigation of a polysaccharide (Fr. I) isolated from the aqueous extract of an edible mushroom, Volvariella diplasia, Carbohydrate Research, 343, 6, 2008. Crossref

  3. Román Miriam de, Boa Eric, Woodward Steve, Wild-gathered fungi for health and rural livelihoods, Proceedings of the Nutrition Society, 65, 2, 2006. Crossref

  4. Zhao Shuang, Gao Qi, Rong Chengbo, Wang Shouxian, Zhao Zhekun, Liu Yu, Xu Jianping, Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products, Journal of Fungi, 6, 4, 2020. Crossref

  5. Chopra Hitesh, Mishra Awdhesh Kumar, Baig Atif Amin, Mohanta Tapan Kumar, Mohanta Yugal Kishore, Baek Kwang-Hyun, Narrative Review: Bioactive Potential of Various Mushrooms as the Treasure of Versatile Therapeutic Natural Product, Journal of Fungi, 7, 9, 2021. Crossref

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