每年出版 12 期
ISSN 打印: 1521-9437
ISSN 在线: 1940-4344
Indexed in
The Shaggy Inc Cap Medicinal Mushroom, Coprinus comatus (O.F.Mull.: Fr.) Pers. (Agaricomycetideae) Substances Interfere with H2O2 Induction of the NF-κB Pathway through Inhibition of IκBα Phosphorylation in MCF7 Breast Cancer Cells
摘要
Breast cancer is the most commonly diagnosed cancer among women. Currently, there is no effective therapy for malignant estrogen-independent breast cancer. In our study, we used hydrogen peroxide, a well-known strong oxidative reagent capable of activating the nuclear factor kappa B (NF-κB) transcription factor. The IC50 value of the culinary-medicinal Shaggy Inc Cap mushroom Coprinus comatus culture liquid crude extract on MCF7 cell viability was found to be as low as 76 μg/mL, and the IC50 value of C. comatus ethyl acetate extract was only 32 μg/ mL. Our results also showed that both extracts significantly affected IκBα phosphorylation in a dose-dependent manner. The effect of ethyl acetate extract was comparable to the effect of curcumin, a known NF-κB pathway inhibitor, and seemed to be the most active inhibitor of H2O2-dependent IκBα phosphorylation. In addition, the data obtained showed that only ethyl acetate extract inhibited the activity of IKK complex, at close to 90% as compared to the control of the untreated sample. These results suggest that C. comatus contains potent compounds capable of inhibiting NF-κB function and also possibly acts as an antitumor agent.
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Zeng Ya-Wen, Yang Jia-Zheng, Pu Xiao-Ying, Du Juan, Yang Tao, Yang Shu-Ming, Zhu Wei-Hua, Strategies of Functional Food for Cancer Prevention in Human Beings, Asian Pacific Journal of Cancer Prevention, 14, 3, 2013. Crossref
-
Patel Seema, Goyal Arun, Recent developments in mushrooms as anti-cancer therapeutics: a review, 3 Biotech, 2, 1, 2012. Crossref
-
Stajić Mirjana, Vukojević Jelena, Ćilerdžić Jasmina, Mushrooms as Potential Natural Cytostatics, in Medicinal Mushrooms, 2019. Crossref
-
Nowakowski Patryk, Naliwajko Sylwia K., Markiewicz‐Żukowska Renata, Borawska Maria H., Socha Katarzyna, The two faces of Coprinus comatus —Functional properties and potential hazards , Phytotherapy Research, 34, 11, 2020. Crossref
-
Wong Jack Ho, Ng Tzi Bun, Chan Helen Hei Ling, Liu Qin, Man Gene Chi Wai, Zhang Chris Zhiyi, Guan Suzhen, Ng Charlene Cheuk Wing, Fang Evandro Fei, Wang Hexiang, Liu Fang, Ye Xiuyun, Rolka Krzysztof, Naude Ryno, Zhao Shuang, Sha Ou, Li Chunman, Xia Lixin, Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials, Applied Microbiology and Biotechnology, 104, 11, 2020. Crossref
-
Vijayalakshmi S., Karthik K., Winny Fred Crossia A., Subashini G., Bhuvaneswari S., Panneerselvam A., Thatikayala Dayakar, Park Jinsub, Park Mi-Kyung, Fungal secondary metabolites: A potential source of anticancer compounds, in New and Future Developments in Microbial Biotechnology and Bioengineering, 2020. Crossref
-
Fedotov O. V. , Phenolic substances as regulators of the intensity of lipid peroxidation processes of the strains Pleurotus eryngii, Fistulina hepatica and Agrocybe cylindracea , Regulatory Mechanisms in Biosystems, 11, 2, 2020. Crossref
-
Ren Jun, Shi Jin-Li, Han Chun-Chao, Liu Zhen-Quan, Guo Jian-You, Isolation and biological activity of triglycerides of the fermented mushroom of Coprinus Comatus , BMC Complementary and Alternative Medicine, 12, 1, 2012. Crossref
-
Nowakowski Patryk, Markiewicz-Żukowska Renata, Bielecka Joanna, Mielcarek Konrad, Grabia Monika, Socha Katarzyna, Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents, Biomedicine & Pharmacotherapy, 143, 2021. Crossref
-
Panda Mrunmaya K., Paul Manish, Singdevsachan Sameer K., Tayung Kumananda, Das Swagat K., Thatoi Hrudayanath, Promising Anti-cancer Therapeutics From Mushrooms: Current Findings and Future Perceptions, Current Pharmaceutical Biotechnology, 22, 9, 2021. Crossref
-
Wang Yiwei, Yu Jiayi, Cui Ran, Lin Jinjin, Ding Xianting, Curcumin in Treating Breast Cancer: A Review, SLAS Technology, 21, 6, 2016. Crossref
-
Hamad Doaa, El-Sayed Heba, Ahmed Wafaa, Sonbol Hana, Ramadan Mohammed Abdel Halim, GC-MS Analysis of Potentially Volatile Compounds of Pleurotus ostreatus Polar Extract: In vitro Antimicrobial, Cytotoxic, Immunomodulatory, and Antioxidant Activities, Frontiers in Microbiology, 13, 2022. Crossref
-
Figueiredo Lélia, Régis Wiliam César Bento, Medicinal mushrooms in adjuvant cancer therapies: an approach to anticancer effects and presumed mechanisms of action, Nutrire, 42, 1, 2017. Crossref
-
Ray Ribhu, Saha Saparja, Paul Santanu, Two novel compounds, ergosterol and ergosta-5,8-dien-3-ol, from Termitomyces heimii Natarajan demonstrate promising anti-hepatocarcinoma activity, Journal of Traditional Chinese Medical Sciences, 9, 4, 2022. Crossref