每年出版 12 期
ISSN 打印: 1521-9437
ISSN 在线: 1940-4344
Indexed in
Outdoor-Cultivated Royal Sun Medicinal Mushroom Agaricus brasiliensis KA21 (Agaricomycetes) Reduces Anticancer Medicine Side Effects
摘要
We investigated whether outdoor-cultivated Agaricus brasiliensis (KA21) could reduce the side effects caused by the anticancer medicine 5-fluorouracil (5-FU). The adverse effects of 5-FU were analyzed in mice by orally administering the drug every day for 5 days. Leukopenia, diarrhea, body weight loss, anorexia, kidney injury, gastrointestinal tract injury, and hair loss were evaluated as side effects. We determined whether these side effects were reduced by the intake of outdoor-cultivated A. brasiliensis. The side effects were reduced in mice receiving the outdoor-cultivated A. brasiliensis but not in those receiving the indoor-cultivated A. brasiliensis. These results suggest that outdoor-cultivated A. brasiliensis is beneficial in reducing the side effects of the anticancer medicine and might, therefore, be useful in improving the quality of life of patients with cancer. Furthermore, because antioxidants have been reported to contribute to the suppression of the side effects of anticancer medicines, the antioxidant activities of different mushrooms were determined. The antioxidant activity of the outdoor-cultivated A. brasiliensis was the highest among all the tested mushrooms. These findings make it clear that the cultivation conditions of A. brasiliensis are important in suppressing the side effects of anticancer medicines. Strong antioxidant activity might be one of the mechanisms through which this pharmacological activity is mediated.
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Wasser SP, Didukh MYA, Amazonas MAL, Nevo E, Stamets P, Eira AF. Is a widely cultivated culinary-medicinal royal sun Agaricus (the himematsutake mushroom) indeed Agaricus blazei Murrill. Int J Med Mushrooms. 2002;4:267-90. doi:10.1615/ IntJMedMushr.v4.i4.10.
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Wasser SP. Medicinal mushrooms in human clinical studies. Part I. Anticancer, oncoimmunological, and immunomodulatory activities: a review. Int J Med Mushrooms. 2017;19:279-317. doi:10.1615/IntJMedMushrooms.v19.i4.10.
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Motoi M, Motoi A, Yamanaka D, Ohno N. Open-label study of the influence of food containing the royal sun mushroom, Agaricus brasiliensis KA21 (higher Basidiomycetes), on the quality of life of healthy human volunteers. Int J Med Mushrooms. 2015;17:799-817.
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Liu Y, Fukuwatari Y, Okumura K, Takeda K, Ishibashi K, Furukawa M, Ohno N, Mori K, Gao M, Motoi M. Immunomodulating activity of Agaricus brasiliensis KA21 in mice and in human volunteers. Evid Based Complement Alternat Med. 2008;5:205-19. doi:10.1093/ecam/nem016.
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Yamanaka D, Liu Y, Motoi M, Ohno N. Royal sun medicinal mushroom, Agaricus brasiliensis KA21 (higher Basidiomycetes), as a functional food in humans. Int J Med Mushrooms. 2013;15:335-43. doi:10.1615/IntJMedMushr.v15.i4.10.
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Yamanaka D, Motoi M, Motoi A, Ohno N. Differences in antioxidant activities of outdoor- and indoor-cultivated Agaricus brasiliensis, and protective effects against carbon tetrachloride-induced acute hepatic injury in mice. BMC Complement Altern Med. 2014;14:454. doi:10.1186/1472-6882-14-454.
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Motoi M, Ishibashi KI, Mizukami O, Miura NN, Adachi Y, Ohno N. Anti beta-glucan antibody in cancer patients (preliminary report). Int J Med Mushrooms. 2004;6:8. doi:10.1615/IntJMedMushr.v6.i1.40.
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Furukawa M, Miura NN, Adachi Y, Motoi M, Ohno N. Effect of Agaricus brasiliensis S. Wasser et al. (Agarico-mycetideae) on murine diabetic model C57BL/Ksj-db/db. Int J Med Mushrooms. 2006;8:115-28. doi:10.1615/IntJMedMushr.v8.i2.30.
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Yamanaka D, Liu Y, Motoi M, Ohno N. Royal sun medicinal mushroom, Agaricus brasiliensis KA21 (higher Basidiomycetes), as a functional food in humans. Int J Med Mushrooms. 2013;15:335-43.
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Ohno N, Furukawa M, Miura NN, Adachi Y, Motoi M, Yadomae T. Antitumor beta glucan from the cultured fruit body of Agaricus blazei. Biol Pharm Bull. 2001;24:820-28.
-
Hartmann K-U, Heidelberger C. Studies on fluorinated pyrimidines: XIII. Inhibition of thymidylate synthetase. J Biol Chem. 1961;236:3006-13.
-
Sternberg A, Petrelli NJ, Au J, Rustum Y, Mittelman A, Creaven P. A combination of 5-fluorouracil and thymidine in advanced colorectal carcinoma. Cancer Chemother Pharmacol. 1984;13:218-22. doi:10.1007/BF00269033.
-
Goldin A, Venditti JM, Macdonald JS, Muggia FM, Henney JE, Devita VT Jr. Current results of the screening program at the Division of Cancer Treatment, National Cancer Institute. Eur J Cancer. 1981;17:129-42. doi:10.1016/0014-2964(81)90027-X.
-
Conroy T, Desseigne F, Ychou M, Bouche O, Guimbaud R, Becouarn Y, Adenis A, Raoul JL, Gourgou-Bourgade S, de la Fouchardiere C, Bennouna J, Bachet JB, Khemissa-Akouz F, Pere-Verge D, Delbaldo C, Assenat E, Chauffert B, Michel P, Montoto-Grillot C, Ducreux M, Groupe Tumeurs Digestives of Unicancer, PRODIGE Intergroup. FOLFIRINOX versus Gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364:1817-25. doi:10.1056/NEJMoa1011923.
-
Anada H, Ashizawa T, Nakamura N. Studies on antitumor effects of 5-fluorouracil by oral administration. Chemotherapy. 1974;22:1074-79. doi:10.11250/chemotherapy1953.22.1074.
-
Yamada J, Akahori Y, Matsuda H, Hasegawa Y, Maeda T, Harada K. Correlation between the DPPH radical scavenging activity and ORAC for dried bonito and other stock types. J Cookery Sci Jpn. 2010;43:201-5. doi:10.11402/cookeryscience.43.201.
-
Tsuchiya T, Honda H, Oikawa M, Kakita T, Oyama A, Oishi H, Tochikubo K, Hashimoto T, Kurihara S, Shibakusa T, Kayahara T. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol. 2016;21:1085-90. doi:10.1007/s10147-016-0996-7.
-
Ishimoto Y, Ishibashi KI, Yamanaka D, Adachi Y, Ito H, Igami K, Miyazaki T, Ohno N. Protection against gut inflammation and sepsis in mice by the autodigested product of the lingzhi medicinal mushroom, Ganoderma lingzhi (Agaricomycetes). Int J Med Mushrooms. 2018;20:809-23. doi:10.1615/IntJMedMushrooms.2018027359.
-
Franja TGD, Ishikawa LLW, Zorzella-Pezavento SFG, Chiuso-Minicucci F, da Cunha MLRS, Sartori A. Impact of malnutrition on immunity and infection. J Venom Anim Toxins Incl Trop Dis. 2009;15(3). doi: 10.1590/S1678-91992009000300003.
-
Hashimoto S, Akanuma A, Motoi M, Imai N, Rodrignes CA, Nameda S, Miura NN, Adachi Y, Ohno N. Effect of culture conditions on the chemical composition and biological activities of Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae). Int J Med Mushrooms. 2006;8:329-342. doi: 10.1615/IntJMedMushr.v8.i4.40.
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Matsumoto-Akanuma A, Akanuma S, Motoi M, Yamagishi A, Ohno N. Cloning and characterization of laccase DNA from the royal sun medicinal mushroom, Agaricus brasiliensis (higher Basidiomycetes). Int J Med Mushrooms. 2014;16(4):375-93.
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Matsumoto-Akanuma A, Akanuma S, Motoi M, Yamagishi A, Ohno N. Partial purification and characterization of polyphenoloxidase from culinary-medicinal royal sun mushroom (the Himematsutake), Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae). Int J Med Mushrooms. 2011;13(1):73-82.
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Yamanaka D, Tada R, Adachi Y, Ishibashi K, Motoi M, Iwakura Y, Ohno N. Agaricus brasiliensis-derived beta-glucans exert immunoenhancing effects via a dectin-1-dependent pathway. Int Immunopharmacol. 2012;14:311-19. doi:10.1016/j. intimp.2012.07.017.