Erscheint 4 Ausgaben pro Jahr
ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537
Indexed in
Insulin Combined with Glucose Improves Spatial Learning and Memory in Aluminum Chloride−Induced Dementia in Rats
ABSTRAKT
Therapeutic intervention using drugs against Alzheimer disease is curative clinically. At present, there are no reports on the curative role of insulin in chronic models of dementia. We evaluated the curative role of insulin and its combination with glucose in dementia. We also investigated the impact of treatments on blood glucose to correlate with cognitive deficit. Further, we analyzed the interaction of treatments with the cholinergic system and oxidative stress in memory centers (i.e., hippocampus and frontal cortex). The antidementia activity of insulin was assessed against aluminum chloride (AlCl3)-induced dementia in rats. Behavioral parameters (Morris water maze test) along with biochemical parameters (Hippocampus and frontal cortex) such as acetylcholinesterase (AChE), catalase, and glutathione (GSH) levels were assessed to correlate cognitive function with cholinergic transmission and oxidative stress. Rats administered insulin and glucose showed improved cognitive function in the Morris water maze test. The combination corrected the diminished level of antioxidant enzymes such as catalase and GSH in the hippocampus and frontal cortex.Combined administration of insulin and glucose to aluminum-treated rats did not inhibit the aluminum action on the acetylcholinesterase enzyme. No significant changes were observed in blood glucose levels between the treatment groups.
-
Alghamdi Badrah Saeed Ali, Possible prophylactic anti-excitotoxic and anti-oxidant effects of virgin coconut oil on aluminium chloride-induced Alzheimer’s in rat models, Journal of Integrative Neuroscience, 17, 3-4, 2018. Crossref
-
Bosebabu Bellamkonda, Cheruku Sri Pragnya, Chamallamudi Mallikarjuna Rao, Nampoothiri Madhavan, Shenoy Rekha R., Nandakumar Krishnadas, Parihar Vipan K., Kumar Nitesh, An Appraisal of Current Pharmacological Perspectives of Sesamol: A Review, Mini-Reviews in Medicinal Chemistry, 20, 11, 2020. Crossref
-
Tabassum Sidra, Misrani Afzal, Yang Li, Exploiting Common Aspects of Obesity and Alzheimer’s Disease, Frontiers in Human Neuroscience, 14, 2020. Crossref
-
Gomes Liana S., Costa Janaína R., Campos Mônica S., Marques Mara R., Biancardi Manoel F., Taboga Sebastião R., Ghedini Paulo C., Santos Fernanda C.A., Aluminum disrupts the prenatal development of the male and female gerbil prostate (Meriones unguiculatus), Experimental and Molecular Pathology, 107, 2019. Crossref