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ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537
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Acute and Subacute Pulmonary Toxicity Caused by a Single Intratracheal Instillation of Colloidal Silver Nanoparticles in Mice: Pathobiological Changes and Metallothionein Responses
ABSTRAKT
To study the acute and subacute pulmonary toxicity of colloidal silver nanoparticles (Ag-NPs), 0 or 100 ppm of Ag-NPs were instilled intratracheally in mice. Cellular and biochemical parameters in bronchoalveolar lavage fluid (BALF) and histological alterations were determined 1, 3, 7, 15, and 30 days after instillation. Ag-NPs induced moderate pulmonary inflammation and injury on BALF indices during the acute period; however, these changes gradually regressed in a time-dependent manner. Concomitant histopathological and laminin immunohistochemical findings generally correlated to BALF data. Superoxide dismutase and metallothionein expression occurred in particle-laden macrophages and alveolar epithelial cells, which correlated to lung lesions in mice treated with Ag-NPs. These findings suggest that instillation of Ag-NPs causes transient moderate acute lung inflammation and tissue damage. Oxidative stress may underlie the induction of injury to lung tissue. Moreover, the expression of metallothionein in tissues indicated the protective response to exposure to Ag-NPs.
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Smulders Stijn, Larue Camille, Sarret Geraldine, Castillo-Michel Hiram, Vanoirbeek Jeroen, Hoet Peter H.M., Lung distribution, quantification, co-localization and speciation of silver nanoparticles after lung exposure in mice, Toxicology Letters, 238, 1, 2015. Crossref
-
Iavicoli Ivo, Leso Veruscka, Schulte Paul A., Biomarkers of susceptibility: State of the art and implications for occupational exposure to engineered nanomaterials, Toxicology and Applied Pharmacology, 299, 2016. Crossref
-
Huo Lingling, Chen Rui, Zhao Lin, Shi Xiaofei, Bai Ru, Long Dingxin, Chen Feng, Zhao Yuliang, Chang Yan-Zhong, Chen Chunying, Silver nanoparticles activate endoplasmic reticulum stress signaling pathway in cell and mouse models: The role in toxicity evaluation, Biomaterials, 61, 2015. Crossref
-
Sussman Eric M., Jayanti Priyanka, Dair Benita J., Casey Brendan J., Assessment of total silver and silver nanoparticle extraction from medical devices, Food and Chemical Toxicology, 85, 2015. Crossref
-
Kang HanGoo, Kim Seungjae, Lee Kwang Hoon, Jin Shan, Kim Seo Hyeong, Lee Kangtaek, Jeon Hyungjoon, Song Young-Geon, Lee Sang-Won, Seo Jinwon, Park Soomin, Choi In-Hong, 5 nm Silver Nanoparticles Amplify Clinical Features of Atopic Dermatitis in Mice by Activating Mast Cells, Small, 13, 9, 2017. Crossref
-
Ahmed Omar Bauomy, Mahmoud Usama Taha, Elganady Sara, Nafady Allam Mohamed, Afifi Salah Mohamed Hassan, Immunomodulatory effect of gelatin-coated silver nanoparticles in mice: Ultrastructural evaluation, Ultrastructural Pathology, 40, 6, 2016. Crossref
-
Pinto Ricardo J.B., Nasirpour Maryam, Carrola Joana, Oliveira Helena, Freire Carmen S.R., Duarte Iola F., Antimicrobial Properties and Therapeutic Applications of Silver Nanoparticles and Nanocomposites, in Antimicrobial Nanoarchitectonics, 2017. Crossref
-
Almansour Mansour, Sajti Csaba Laszlo, Shraideh Ziad, Jarrar Bashir, Pulmonary Histological Alterations Induced by 20 nm Silver Nanoparticles, Journal of Nano Research, 35, 2015. Crossref
-
Keung Yi-Kong, Wang Tina, Hong-Lung Hu Eddie, Acute myeloid leukemia with complex cytogenetic abnormalities associated with long-term use of oral colloidal silver as nutritional supplement – Case report and review of literature, Journal of Oncology Pharmacy Practice, 26, 1, 2020. Crossref
-
Li Lu, Bi Zhenfei, Hu Yuzhu, Sun Lu, Song Yanlin, Chen Siyuan, Mo Fei, Yang Jingyun, Wei Yuquan, Wei Xiawei, Silver nanoparticles and silver ions cause inflammatory response through induction of cell necrosis and the release of mitochondria in vivo and in vitro, Cell Biology and Toxicology, 37, 2, 2021. Crossref
-
Ambardar Sharad, Nguyen Dang, Binder Grace, Withers Zachary W., Voronine Dmitri V., Quantum Leap from Gold and Silver to Aluminum Nanoplasmonics for Enhanced Biomedical Applications, Applied Sciences, 10, 12, 2020. Crossref
-
Zhang Bingjie, Liu Na, Liu Qian S., Zhang Jianqing, Zhou Qunfang, Jiang Guibin, Silver nanoparticles induce size-dependent and particle-specific neurotoxicity to primary cultures of rat cerebral cortical neurons, Ecotoxicology and Environmental Safety, 198, 2020. Crossref
-
Wang Liming, Zhang Tianlu, Li Panyun, Huang Wanxia, Tang Jinglong, Wang Pengyang, Liu Jing, Yuan Qingxi, Bai Ru, Li Bai, Zhang Kai, Zhao Yuliang, Chen Chunying, Use of Synchrotron Radiation-Analytical Techniques To Reveal Chemical Origin of Silver-Nanoparticle Cytotoxicity, ACS Nano, 9, 6, 2015. Crossref
-
Pavlík Vojtěch, Sobotka Luboš, Pejchal Jaroslav, Čepa Martin, Nešporová Kristina, Arenbergerová Monika, Mrózková Adéla, Velebný Vladimír, Silver distribution in chronic wounds and the healing dynamics of chronic wounds treated with dressings containing silver and octenidine, The FASEB Journal, 35, 5, 2021. Crossref