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Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Zoledronic Acid Aggravates Kidney Damage During Ischemia Reperfusion Injury in Rat

Volumen 34, Ausgabe 1, 2015, pp. 53-61
DOI: 10.1615/JEnvironPatholToxicolOncol.2015012424
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ABSTRAKT

Introduction: Zoledronic acid (ZA), a bisphosphonate, increases the levels of cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), and reactive oxygen species (ROS) in subjects without cancer. Increased production of ROS, TNF-α, and IL-6 during ischemia and reperfusion (I/R) injury stimulates apoptosis that leads to renal injury. We aimed to investigate whether ZA treatment has a protective effect on renal tissues during I/R. Materials and Methods: Twenty-four Sprague-Dawley rats were used in this study, and they were subdivided randomly into three groups, each containing eight rats. Infrarenal abdominal aortic cross ligation was performed on the I/R group. After 2 h of ischemia, 2 h of reperfusion was applied. A single dose of 100 µg/kg ZA was administered intraperitoneally to the ZA group. I/R was performed after 48 h. Results: Whereas TNF-α, IL-6, and nitric oxide (NO) levels of the I/R group were higher than those of the control group, TNF-α, IL-6, and NO levels of the ZA group were higher than those of the I/R group [TNF-α (p=0.038), IL-6 (p=0.012), NO (p=0.002), and caspase-3 (p=0.037)] and the control group [TNF-α (p<0.001), IL-6 (p<0.001), NO (p<0.001), and caspase-3 (p<0.001)]. Whereas the carbonic anhydrase II (CA-II) level of the ZA group was lower than that of the control group (p=0.040), the CA-II level of the I/R group was higher than that of the control group (p=0.020). Conclusion: ZA may aggravate renal injury during I/R by increasing cytokine production and apoptosis. It may also increase renal injury and metabolic acidosis during I/R by suppressing CA-II enzyme activities.

REFERENZIERT VON
  1. Wu Sheng-Nan, Chen Hui-Zhen, Chou Yu-Hung, Huang Yan-Ming, Lo Yi-Ching, Inhibitory actions by ibandronate sodium, a nitrogen-containing bisphosphonate, on calcium-activated potassium channels in Madin–Darby canine kidney cells, Toxicology Reports, 2, 2015. Crossref

  2. Carbonare Luca Dalle, Matte’ Alessandro, Valenti Maria Teresa, Siciliano Angela, Mori Antonio, Schweiger Vittorio, Zampieri Gino, Perbellini Luigi, De Franceschi Lucia, Hypoxia-reperfusion affects osteogenic lineage and promotes sickle cell bone disease, Blood, 126, 20, 2015. Crossref

  3. Pócs Levente, Janovszky Ágnes, Ocsovszki Imre, Kaszaki József, Piffkó József, Szabó Andrea, Microcirculatory consequences of limb ischemia/reperfusion in ovariectomized rats treated with zoledronic acid, Journal of Orthopaedic Surgery and Research, 14, 1, 2019. Crossref

  4. Qu Xingzhou, Sun Zhaoqi, Wang Yang, Ong Hui Shan, Zoledronic acid promotes osteoclasts ferroptosis by inhibiting FBXO9-mediated p53 ubiquitination and degradation, PeerJ, 9, 2021. Crossref

  5. Bakr Alaa F., Shao Ping, Farag Mohamed A., Recent advances in glycyrrhizin metabolism, health benefits, clinical effects and drug delivery systems for efficacy improvement; a comprehensive review, Phytomedicine, 99, 2022. Crossref

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