Erscheint 4 Ausgaben pro Jahr
ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537
IF:
2.4
5-Year IF:
2.8
Immediacy Index:
0.5
Eigenfactor:
0.00049
JCI:
0.59
SJR:
0.429
SNIP:
0.507
CiteScore™::
3.9
H-Index:
49
Indexed in
Acute Exposure of Uranyl Nitrate Causes Lipid Peroxidation and Histopathological Damage in Brain and Bone of Wistar Rat
Get access
ABSTRAKT
Although the kidneys are the main target organs for uranium (U) toxicity, recent studies have shown that U can cross the blood-brain barrier to accumulate in the brain. Uranyl nitrate (U-238)—induced oxidative damage was investigated in brain and bone of Wistar rats after intraperitoneal injection of uranyl nitrate at acute doses either nephrotoxic (576 μg of U/kg body weight) or subnephrotoxic (144 μg U/kg body weight). The health effects of U administration at 576 μg of U/kg body weight were seen in terms of decrease in food intake and no gain in body weight compared to respective controls. These alterations were correlated with increased lipid peroxidation as measured by thiobarbituric acid reactive substances in rat brain and bone. However, at lower dosage of U (144 μg U/kg body weight), no significant lipid peroxidation was observed in brain and bone. Histological examination of U-treated (576 μg of U/kg body weight) rat brain tissues showed marked and diffuse cystic degeneration and a similar pattern in histological alterations was observed in kidneys in treated animals; whereas no significant histological change was observed in rat brains and kidney treated with a lower dose of U (144 μg U/kg body weight). It is concluded that administration of U at an acute nephrotoxic dose caused oxidative stress in brain and bone manifested as lipid peroxidation and histopathological damage.
-
Jiang George C.-T., Aschner Michael, Depleted Uranium, in Handbook of Toxicology of Chemical Warfare Agents, 2009. Crossref
-
Mitrović Branislava, Vitorović Gordana, Jovanović Milijan, Lazarević-Macanović Mirjana, Andrić Velibor, Stojanović Mirjana, Daković Aleksandra, Vitorović Duško, Uranium distribution in broiler organs and possibilities for protection, Radiation and Environmental Biophysics, 53, 1, 2014. Crossref
-
Briner Wayne, The Toxicity of Depleted Uranium, International Journal of Environmental Research and Public Health, 7, 1, 2010. Crossref
-
Dinocourt Céline, Legrand Marie, Dublineau Isabelle, Lestaevel Philippe, The neurotoxicology of uranium, Toxicology, 337, 2015. Crossref
-
Pandey Badri N., Kumar Amit, Tiwari Prabha, Mishra Kaushala P., Radiobiological basis in management of accidental radiation exposure, International Journal of Radiation Biology, 86, 8, 2010. Crossref
-
Jiang George C-T, Aschner Michael, Depleted Uranium, in Handbook of Toxicology of Chemical Warfare Agents, 2015. Crossref
-
Lestaevel P., Romero E., Dhieux B., Ben Soussan H., Berradi H., Dublineau I., Voisin P., Gourmelon P., Different pattern of brain pro-/anti-oxidant activity between depleted and enriched uranium in chronically exposed rats, Toxicology, 258, 1, 2009. Crossref
-
Melo D., Burkart W., Uranium: Environmental Pollution and Health Effects, in Encyclopedia of Environmental Health, 2011. Crossref
-
Uranium (natural and depleted) and its inorganic compounds (Inhalable fraction) [MAK Value Documentation, 2012], in The MAK-Collection for Occupational Health and Safety, 2015. Crossref
-
Guzmán Luis, Durán-Lara Esteban, Donoso Wendy, Nachtigall Fabiane, Santos Leonardo, In Vivo Nanodetoxication for Acute Uranium Exposure, Molecules, 20, 6, 2015. Crossref
-
Kumar Amit, Ali Manjoor, Mishra Pravin, Pandey B. N., Sharma Pragya, Mishra Kaushala Prasad, Thorium-induced neurobehavioural and neurochemical alterations in Swiss mice, International Journal of Radiation Biology, 85, 4, 2009. Crossref
-
Kumar Amit, Mishra Pravin, Ghosh Somnath, Sharma Pragya, Ali Manjoor, Pandey B. N., Mishra Kaushala Prasad, Thorium-induced oxidative stress mediated toxicity in mice and its abrogation by Diethylenetriamine pentaacetate, International Journal of Radiation Biology, 84, 4, 2008. Crossref
-
Dinocourt Céline, Uranium and the Central Nervous System: What Should We Learn from Recent New Tools and Findings?, in Neurotoxicity of Metals, 18, 2017. Crossref
-
Poisson C, Rouas C, Manens L, Dublineau I, Gueguen Y, Antioxidant status in rat kidneys after coexposure to uranium and gentamicin, Human & Experimental Toxicology, 33, 2, 2014. Crossref
-
Abdel-Rahman Mona, Rezk Mohamed Mahmoud, Kader Seham Abdel, The role of cardamom on the hazardous effects of depleted uranium in cerebellum and midbrain of albino rats, Toxicology and Environmental Health Sciences, 9, 1, 2017. Crossref
-
Mitrović Branislava, Stojanović Mirjana, Sekulić Živko, Andrić Velibor, Vićentijević Mihajlo, Vranješ Borjana, Toxicity of high uranium doses in broilers and protection with mineral adsorbents, Radiation and Environmental Biophysics, 58, 3, 2019. Crossref
-
Melo D., Burkart W., Uranium: Environmental Pollution and Health Effects, in Encyclopedia of Environmental Health, 2011. Crossref
-
Ran Yonghong, Wang Shuang, Zhao Yazhen, Li Juan, Ran Xinze, Hao Yuhui, A review of biological effects and treatments of inhaled depleted uranium aerosol, Journal of Environmental Radioactivity, 222, 2020. Crossref
-
Benavides-Garcia Maria G., Balasubramanian Krishnan, Structural Insights into the Binding of Uranyl with Human Serum Protein Apotransferrin Structure and Spectra of Protein−Uranyl Interactions, Chemical Research in Toxicology, 22, 9, 2009. Crossref