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Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Change in Nicotine-Induced VEGF, PGE2 AND COX-2 Expression Following COX Inhibition in Human Oral Squamous Cancer

Volumen 31, Ausgabe 4, 2012, pp. 349-356
DOI: 10.1615/JEnvironPatholToxicolOncol.2013005365
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ABSTRAKT

Cigarette smoke has been documented to be related to the development of cancer. However, the exact mechanism for the carcinogenic action of cigarette smoke is still unknown. Nicotine is recognized to be the major compound in cigarette smoke and has been suggested to play a role in oral cancer via a cyclooxygenase (COX)/ prostaglandin−dependent pathway. This study was designed to evaluate the action of nicotine in the oral cancer cell and to further examine whether COX-2 is responsible for expression of tumor-associated angiogenic vascular endothelial growth factor (VEGF) in vitro. Viability of human oral squamous cancer cells (BHY) was measured using MTT assay. Protein expression was determined by Western blot and immunoassay kits. We found that exposure of BHY cells to nicotine (200 µg/mL for 6 hours) resulted in 2.9-fold induction of COX-2 expression as well as a 4-fold increase in VEGF levels compared with a control group. Pretreatment with celecoxib inhibited nicotine-induced change in the expression of VEGF and COX-2. The results suggest that stimulation of COX-2 and VEGF expression can contribute as important factors in the tumorigenic action of nicotine in oral cancer progression. This effect can be blocked by celecoxib, suggesting an interaction of nicotine and COX-2 pathways.

REFERENZIERT VON
  1. Grando Sergei A., Connections of nicotine to cancer, Nature Reviews Cancer, 14, 6, 2014. Crossref

  2. Kabirian Fatemeh, Amoabediny Ghassem, Haghighipour Nooshin, Salehi-Nik Nasim, Zandieh-Doulabi Behrouz, Nitric oxide secretion by endothelial cells in response to fluid shear stress, aspirin, and temperature, Journal of Biomedical Materials Research Part A, 103, 3, 2015. Crossref

  3. Chernyavsky Alex I., Shchepotin Igor B., Grando Sergei A., Mechanisms of growth-promoting and tumor-protecting effects of epithelial nicotinic acetylcholine receptors, International Immunopharmacology, 29, 1, 2015. Crossref

  4. Kaya Tijen Temiz, Altun Ahmet, Turgut Nergiz Hacer, Ataseven Hilmi, Koyluoglu Gokhan, Effects of a Multikinase Inhibitor Motesanib (AMG 706) Alone and Combined with the Selective DuP-697 COX-2 Inhibitor on Colorectal Cancer Cells, Asian Pacific Journal of Cancer Prevention, 17, 3, 2016. Crossref

  5. Hasan Feza, Katiyar Tridiv, Maurya Shailendra S., Yadav Vinay, Yadav Sanjay, Pandey Rahul, Mehrotra Divya, Hadi Rahat, Singh Sudhir, Bhatt Madan L., Parmar Devendra, Similarities in mRNA expression of peripheral blood drug metabolizing enzymes and cancer marker genes with biopsy samples of head and neck cancer patients, Biomarkers, 24, 6, 2019. Crossref

  6. Roy , Monisha , Padmavathi , Lalhruaitluanga , Kumar , Singh , Bordoloi , Baruah , Ahmed , Longkumar , Arfuso , Kumar , Kunnumakkara , Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma, Biomolecules, 9, 7, 2019. Crossref

  7. Nasry Walaa Hamed Shaker, Wang Haili, Jones Kathleen, Tesch Marvin, Rodriguez-Lecompte Juan Carlos, Martin Chelsea K., Cyclooxygenase and CD147 expression in oral squamous cell carcinoma patient samples and cell lines, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 128, 4, 2019. Crossref

  8. Saka‐Herrán Constanza, Jané‐Salas Enric, Estrugo‐Devesa Albert, López‐López José, Head and neck cancer and non‐steroidal anti‐inflammatory drugs: Systematic review and meta‐analysis, Head & Neck, 43, 5, 2021. Crossref

  9. Chernyavsky Alex I, Shchepotin Igor B, Galitovkiy Valentin, Grando Sergei A, Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors, BMC Cancer, 15, 1, 2015. Crossref

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