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ISSN Druckformat: 0731-8898
ISSN Online: 2162-6537
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Membrane-Associated MMP-2 in Human Cervical Cancer
ABSTRAKT
Matrixmetalloproteinases (MMPs) are a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. The importance of MMPs in tumor development and invasion is well known. Recent studies have strongly indicated the presence of a functional complex consisting of avb3 integrin, membrane type-1 metalloproteinase-2 (MT1-MMP), and tissue inhibitor of metalloproteinase-2 (TIMP-2) on tumor cell surface, which helps the activation of MMP-2. In this article, we report on the association of active MMP-2 with the membrane fraction of human cervical cancer cells. The association of MMP-2 with avb3 integrin and the expression of membrane type MT1-MMP strongly indicate the role of avb3/MT1-MMP/TIMP-2 complex in the activation of MMP-2 in cervical cancer tissue membrane fraction. The membrane-associated activated MMP-2 may have a role in the migration of tumor cells during invasion.
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Zhang Ying, Qian Haili, Lin Chen, Lang Jinghe, Xiang Yang, Fu Ming, Zhang Xueyan, Liang Xiao, Adenovirus carrying TIMP-3: A potential tool for cervical cancer treatment, Gynecologic Oncology, 108, 1, 2008. Crossref
-
Marano Grazia, Gronewold Claas, Frank Martin, Merling Anette, Kliem Christian, Sauer Sandra, Wiessler Manfred, Frei Eva, Schwartz-Albiez Reinhard, An easily accessible sulfated saccharide mimetic inhibits in vitro human tumor cell adhesion and angiogenesis of vascular endothelial cells, Beilstein Journal of Organic Chemistry, 8, 2012. Crossref
-
Damke Gabrielle Marconi Zago Ferreira, Damke Edilson, de Souza Bonfim-Mendonça Patrícia, Ratti Bianca Altrão, de Freitas Meirelles Lyvia Eloiza, da Silva Vânia Ramos Sela, Gonçalves Renato Sonchini, César Gabriel Batista, de Oliveira Silva Sueli, Caetano Wilker, Hioka Noboru, Souza Raquel Pantarotto, Consolaro Marcia Edilaine Lopes, Selective photodynamic effects on cervical cancer cells provided by P123 Pluronic®-based nanoparticles modulating hypericin delivery, Life Sciences, 255, 2020. Crossref
-
Pandit Anuradha, Begum Yasmin, Saha Priyanka, Srivastava Amit Kumar, Swarnakar Snehasikta, Approaches Toward Targeting Matrix Metalloproteases for Prognosis and Therapies in Gynecological Cancer: MicroRNAs as a Molecular Driver, Frontiers in Oncology, 11, 2022. Crossref
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Zhai Yali, Hotary Kevin B., Nan Bin, Bosch F. Xavier, Muñoz Nubia, Weiss Stephen J., Cho Kathleen R., Expression of Membrane Type 1 Matrix Metalloproteinase Is Associated with Cervical Carcinoma Progression and Invasion, Cancer Research, 65, 15, 2005. Crossref