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Journal of Environmental Pathology, Toxicology and Oncology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Membrane-Associated MMP-2 in Human Cervical Cancer

Volumen 22, Ausgabe 2, 2003, 8 pages
DOI: 10.1615/JEnvPathToxOncol.v22.i2.20
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ABSTRAKT

Matrixmetalloproteinases (MMPs) are a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. The importance of MMPs in tumor development and invasion is well known. Recent studies have strongly indicated the presence of a functional complex consisting of avb3 integrin, membrane type-1 metalloproteinase-2 (MT1-MMP), and tissue inhibitor of metalloproteinase-2 (TIMP-2) on tumor cell surface, which helps the activation of MMP-2. In this article, we report on the association of active MMP-2 with the membrane fraction of human cervical cancer cells. The association of MMP-2 with avb3 integrin and the expression of membrane type MT1-MMP strongly indicate the role of avb3/MT1-MMP/TIMP-2 complex in the activation of MMP-2 in cervical cancer tissue membrane fraction. The membrane-associated activated MMP-2 may have a role in the migration of tumor cells during invasion.

REFERENZIERT VON
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  2. Marano Grazia, Gronewold Claas, Frank Martin, Merling Anette, Kliem Christian, Sauer Sandra, Wiessler Manfred, Frei Eva, Schwartz-Albiez Reinhard, An easily accessible sulfated saccharide mimetic inhibits in vitro human tumor cell adhesion and angiogenesis of vascular endothelial cells, Beilstein Journal of Organic Chemistry, 8, 2012. Crossref

  3. Damke Gabrielle Marconi Zago Ferreira, Damke Edilson, de Souza Bonfim-Mendonça Patrícia, Ratti Bianca Altrão, de Freitas Meirelles Lyvia Eloiza, da Silva Vânia Ramos Sela, Gonçalves Renato Sonchini, César Gabriel Batista, de Oliveira Silva Sueli, Caetano Wilker, Hioka Noboru, Souza Raquel Pantarotto, Consolaro Marcia Edilaine Lopes, Selective photodynamic effects on cervical cancer cells provided by P123 Pluronic®-based nanoparticles modulating hypericin delivery, Life Sciences, 255, 2020. Crossref

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