Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
Antigen Delivery to Plasmacytoid Dendritic Cells -Induction of Tolerance and Immunity
Get access
ABSTRAKT
Dendritic cells are professional antigen presenting cells linking the innate and the adaptive immune system. Antibody mediated antigen delivery to functionally distinct DC subpopulations is a promising approach to induce or inhibit antigen specific immune responses in vivo and is useful for designing therapeutic vaccination strategies. This review focuses on the state of the art of this technique and describes recent findings of antigen targeting to the subpopulation of plasmacytoid dendritic cells and the possibilities to induce immunity or attenuate autoimmunity by delivering antigens specifically to this cell type.
-
Chappell Craig P., Giltiay Natalia V., Dresch Christiane, Clark Edward A., Controlling immune responses by targeting antigens to dendritic cell subsets and B cells, International Immunology, 26, 1, 2014. Crossref
-
Dillon Patrick M., Slingluff Craig L., Peptide Vaccine: Overview, in Cancer Therapeutic Targets, 2017. Crossref
-
Chappell Craig P., Giltiay Natalia V., Draves Kevin E., Chen ChangHung, Hayden-Ledbetter Martha S., Shlomchik Mark J., Kaplan Daniel H., Clark Edward A., Targeting Antigens through Blood Dendritic Cell Antigen 2 on Plasmacytoid Dendritic Cells Promotes Immunologic Tolerance, The Journal of Immunology, 192, 12, 2014. Crossref
-
Dillon Patrick M., Slingluff Craig L., Peptide Vaccine: Overview, in Cancer Therapeutic Targets, 2015. Crossref
-
Biessen Erik A.L., Christ Anette, Plasmacytoid Dendritic Cells in Atherosclerosis, Circulation, 130, 16, 2014. Crossref