Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 1040-8401
ISSN Online: 2162-6472
Indexed in
Regulation of Airway Innate and Adaptive Immune Responses: The IL-17 Paradigm
ABSTRAKT
IL-17 is a proinflammatory cytokine produced by immune cells. Its significance in host defense and disease development has been demonstrated in various infection and autoimmune models. Recently, additional studies have shown that IL-17 is also important in modulating airway immune response in several aspects. Along with the well-established Th1/Th2 model, new discoveries regarding the Th17 lineage and IL-17 functions have added an extra twist to the already complicated cytokine network that regulates airway immunity. The IL-17 receptor is expressed on blood cells, as well as on structural cells such as the epithelial cells in the airway. Therefore, the effect of IL-17 on airway immunity is very broad, covering both the innate and the adaptive aspects. In this review, we summarize the findings of recent studies on IL-17 signaling and function in pulmonary immune response, and the implications of IL-17 in disease pathogenesis.
-
Montalbano Angela Marina, Anzalone Giulia, Albano Giusy Daniela, Sano Caterina Di, Gagliardo Rosalia, Bonanno Anna, Riccobono Loredana, Nicolini Gabriele, Ingrassia Eleonora, Gjomarkaj Mark, Profita Mirella, Beclomethasone dipropionate and formoterol reduce oxidative/nitrosative stress generated by cigarette smoke extracts and IL-17A in human bronchial epithelial cells, European Journal of Pharmacology, 718, 1-3, 2013. Crossref
-
del Cacho Emilio, Gallego Margarita, Lillehoj Hyun, Quílez Joaquín, Lillehoj Erik P, Ramo Ana, Sánchez-Acedo Caridad, IL-17A regulates Eimeria tenella schizont maturation and migration in avian coccidiosis, Veterinary Research, 45, 1, 2014. Crossref
-
Xu G., Zhang L., Wang D. Y., Xu R., Liu Z., Han D. M., Wang X. D., Zuo K. J., Li H. B., Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells, Allergy, 65, 5, 2010. Crossref
-
Montalbano Angela Marina, Riccobono Loredana, Siena Liboria, Chiappara Giuseppina, Di Sano Caterina, Anzalone Giulia, Gagliardo Rosalia, Ricciardolo Fabio L.M., Sorbello Valentina, Pipitone Loredana, Vitulo Patrizio, Profita Mirella, Cigarette smoke affects IL-17A, IL-17F and IL-17 receptor expression in the lung tissue: Ex vivo and in vitro studies, Cytokine, 76, 2, 2015. Crossref
-
Martín Pilar, Gómez Manuel, Lamana Amalia, Marín Adela Matesanz, Cortés José R., Ramírez-Huesca Marta, Barreiro Olga, López-Romero Pedro, Gutiérrez-Vázquez Cristina, de la Fuente Hortensia, Cruz-Adalia Aránzazu, Sánchez-Madrid Francisco, The leukocyte activation antigen CD69 limits allergic asthma and skin contact hypersensitivity, Journal of Allergy and Clinical Immunology, 126, 2, 2010. Crossref
-
Holt Patrick G., Strickland Deborah H., Interactions between innate and adaptive immunity in asthma pathogenesis: New perspectives from studies on acute exacerbations, Journal of Allergy and Clinical Immunology, 125, 5, 2010. Crossref
-
Fahy John V., Dickey Burton F., Airway Mucus Function and Dysfunction, New England Journal of Medicine, 363, 23, 2010. Crossref
-
Albano Giusy Daniela, Bonanno Anna, Cavalieri Luca, Ingrassia Eleonora, Di Sano Caterina, Siena Liboria, Riccobono Loredana, Gagliardo Rosalia, Profita Mirella, Effect of High, Medium, and Low Molecular Weight Hyaluronan on Inflammation and Oxidative Stress in anIn VitroModel of Human Nasal Epithelial Cells, Mediators of Inflammation, 2016, 2016. Crossref
-
Albano Giusy Daniela, Di Sano Caterina, Bonanno Anna, Riccobono Loredana, Gagliardo Rosalia, Chanez Pascal, Gjomarkaj Mark, Montalbano Angela Marina, Anzalone Giulia, La Grutta Stefania, Ricciardolo Fabio Luigi Massimo, Profita Mirella, Tasken Kjetil, Th17 Immunity in Children with Allergic Asthma and Rhinitis: A Pharmacological Approach, PLoS ONE, 8, 4, 2013. Crossref
-
Leach Richard J., O'Neill Ronan G., Fitzpatrick Julie L., Williams John L., Glass Elizabeth J., Varga Steven M., Quantitative Trait Loci Associated with the Immune Response to a Bovine Respiratory Syncytial Virus Vaccine, PLoS ONE, 7, 3, 2012. Crossref
-
Anzalone Giulia, Gagliardo Rosalia, Bucchieri Fabio, Albano Giusy Daniela, Siena Liboria, Montalbano Angela Marina, Bonanno Anna, Riccobono Loredana, Pieper Michael Paul, Gjomarkaj Mark, Profita Mirella, IL-17A induces chromatin remodeling promoting IL-8 release in bronchial epithelial cells: Effect of Tiotropium, Life Sciences, 152, 2016. Crossref
-
Montalbano Angela Marina, Albano Giusy Daniela, Bonanno Anna, Riccobono Loredana, Di Sano Caterina, Ferraro Maria, Siena Liboria, Anzalone Giulia, Gagliardo Rosalia, Pieper Michael Paul, Gjomarkaj Mark, Profita Mirella, Autocrine Acetylcholine, Induced by IL-17A via NFκB and ERK1/2 Pathway Activation, Promotes MUC5AC and IL-8 Synthesis in Bronchial Epithelial Cells, Mediators of Inflammation, 2016, 2016. Crossref
-
Liu Zhan-Ju, Yadav Praveen K, Su Jing-Ling, Wang Jun-Shan, Fei Ke, Potential role of Th17 cells in the pathogenesis ofinflammatory bowel disease, World Journal of Gastroenterology, 15, 46, 2009. Crossref
-
Mori Kazutaka, Fujisawa Tomoyuki, Kusagaya Hideki, Yamanaka Katsumasa, Hashimoto Dai, Enomoto Noriyuki, Inui Naoki, Nakamura Yutaro, Maekawa Masato, Suda Takafumi, Thatcher Thomas H, Synergistic Proinflammatory Responses by IL-17A and Toll-Like Receptor 3 in Human Airway Epithelial Cells, PLOS ONE, 10, 9, 2015. Crossref
-
Yamanaka Katsumasa, Fujisawa Tomoyuki, Kusagaya Hideki, Mori Kazutaka, Niwa Mitsuru, Furuhashi Kazuki, Kono Masato, Hamada Etsuko, Suda Takafumi, Maekawa Masato, IL-13 regulates IL-17C expression by suppressing NF-κB-mediated transcriptional activation in airway epithelial cells, Biochemical and Biophysical Research Communications, 495, 1, 2018. Crossref
-
Anzalone Giulia, Albano Giusy Daniela, Montalbano Angela Marina, Riccobono Loredana, Bonanno Anna, Gagliardo Rosalia, Bucchieri Fabio, Marchese Roberto, Moscato Monica, Profita Mirella, IL-17A-associated IKK-α signaling induced TSLP production in epithelial cells of COPD patients, Experimental & Molecular Medicine, 50, 10, 2018. Crossref
-
Park Seoung Ju, Lee Kyung Sun, Kim So Ri, Min Kyung Hoon, Choe Yeong Hun, Moon Hee, Chae Han Jung, Yoo Wan Hee, Lee Yong Chul, Peroxisome Proliferator-Activated Receptor γ Agonist Down-Regulates IL-17 Expression in a Murine Model of Allergic Airway Inflammation, The Journal of Immunology, 183, 5, 2009. Crossref
-
Wang Chuanwu, Kang Seung G., HogenEsch Harm, Love Paul E., Kim Chang H., Retinoic Acid Determines the Precise Tissue Tropism of Inflammatory Th17 Cells in the Intestine, The Journal of Immunology, 184, 10, 2010. Crossref
-
Zhang Yuanfeng, Wang Zheyi, Zhang Yue, Tong Hongxuan, Zhang Yiling, Lu Tao, Potential Mechanisms for Traditional Chinese Medicine in Treating Airway Mucus Hypersecretion Associated With Coronavirus Disease 2019, Frontiers in Molecular Biosciences, 7, 2020. Crossref
-
Parvez Faruque, Lauer Fredine T., Factor-Litvak Pam, Islam Tariqul, Eunus Mahbubul, Horayara M. Abu, Rahman Mizanour, Sarwar Golam, Ahsan Habibul, Graziano Joseph H., Burchiel Scott W., Hossain Khaled, Exposure to arsenic and level of Vitamin D influence the number of Th17 cells and production of IL-17A in human peripheral blood mononuclear cells in adults, PLOS ONE, 17, 4, 2022. Crossref
-
Kusagaya Hideki, Fujisawa Tomoyuki, Yamanaka Katsumasa, Mori Kazutaka, Hashimoto Dai, Enomoto Noriyuki, Inui Naoki, Nakamura Yutaro, Wu Reen, Maekawa Masato, Suda Takafumi, Chida Kingo, Toll-Like Receptor–Mediated Airway IL-17C Enhances Epithelial Host Defense in an Autocrine/Paracrine Manner, American Journal of Respiratory Cell and Molecular Biology, 50, 1, 2014. Crossref