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Critical Reviews™ in Eukaryotic Gene Expression

Erscheint 6 Ausgaben pro Jahr

ISSN Druckformat: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Diversity and Function of Orphan Nuclear Receptors in Nematodes

Volumen 12, Ausgabe 1, 2002, 24 pages
DOI: 10.1615/CritRevEukaryotGeneExpr.v12.i1.40
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ABSTRAKT

Nuclear receptors (NRs) have key regulatory functions in a wide range of biological processes and are one of the most abundant classes of transcriptional regulators in metazoans. NRs are particularly numerous in nematodes, in which the NR gene family has undergone extensive expansion and diversification, providing an evolutionary structure function experiment that is yielding new perspectives on the mechanisms of NR function and on nematode biology. The genome sequence of the free-living nematode Caenorhabditis elegans reveals 270 predicted NR genes, more than fivefold more than observed for any other species to date, though existing data suggest that NR genes are similarly abundant in other nematodes. Most of the currently available information regarding the functions of nematode NRs comes from ongoing studies with C. elegans, and we review here what has been learned thus far in three key areas: the relationships of C. elegans NRs to those in other species; the biochemical consequences of nematode NR sequence diversity

REFERENZIERT VON
  1. Thomas J. H., Genome evolution in Caenorhabditis, Briefings in Functional Genomics and Proteomics, 7, 3, 2008. Crossref

  2. Grant Warwick N, Behm Carolyn A, Target identification and validation for anthelmintic discovery, Expert Opinion on Drug Discovery, 2, sup1, 2007. Crossref

  3. Vohanka Jaroslav, Šimečková Kateřina, Machalová Eliška, Behenský František, Krause Michael W., Kostrouch Zdenek, Kostrouchová Marta, Diversification of fasting regulated transcription in a cluster of duplicated nuclear hormone receptors in C. elegans, Gene Expression Patterns, 10, 6, 2010. Crossref

  4. Shan Ge, Kim Kyuhyung, Li Chris, Walthall W.W., Convergent genetic programs regulate similarities and differences between related motor neuron classes in Caenorhabditis elegans, Developmental Biology, 280, 2, 2005. Crossref

  5. Gissendanner Chris R., Crossgrove Kirsten, Kraus Kelly A., Maina Claude V., Sluder Ann E., Expression and function of conserved nuclear receptor genes in Caenorhabditis elegans, Developmental Biology, 266, 2, 2004. Crossref

  6. Wightman Bruce, Ebert Bryan, Carmean Nicole, Weber Katherine, Clever Sheila, The C. elegans nuclear receptor gene fax-1 and homeobox gene unc-42 coordinate interneuron identity by regulating the expression of glutamate receptor subunits and other neuron-specific genes, Developmental Biology, 287, 1, 2005. Crossref

  7. Narasimhan Kamesh, Lambert Samuel A, Yang Ally WH, Riddell Jeremy, Mnaimneh Sanie, Zheng Hong, Albu Mihai, Najafabadi Hamed S, Reece-Hoyes John S, Fuxman Bass Juan I, Walhout Albertha JM, Weirauch Matthew T, Hughes Timothy R, Mapping and analysis of Caenorhabditis elegans transcription factor sequence specificities, eLife, 4, 2015. Crossref

  8. DeMeo Stephen D, Lombel Rebecca M, Cronin Melissa, Smith Eric L, Snowflack Danielle R, Reinert Kristy, Clever Sheila, Wightman Bruce, Specificity of DNA-binding by the FAX-1 and NHR-67 nuclear receptors of Caenorhabditis elegans is partially mediated via a subclass-specific P-box residue, BMC Molecular Biology, 9, 1, 2008. Crossref

  9. Taubert Stefan, Van Gilst Marc R., Hansen Malene, Yamamoto Keith R., A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans, Genes & Development, 20, 9, 2006. Crossref

  10. Weber Katherine P, Alvaro Christopher G, Baer G Michael, Reinert Kristy, Cheng Genevieve, Clever Sheila, Wightman Bruce, Analysis of C. elegans NR2E nuclear receptors defines three conserved clades and ligand-independent functions, BMC Evolutionary Biology, 12, 1, 2012. Crossref

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