Erscheint 6 Ausgaben pro Jahr
ISSN Druckformat: 1045-4403
ISSN Online: 2162-6502
Indexed in
Thymosin β4: A Potential Molecular Target for Tumor Therapy
ABSTRAKT
Thymosin β4 (Tβ4), a 5 kDa protein, has been demonstrated to play an important role in a variety of biological activities, such as actin sequestering, cellular motility, migration, inflammation, and damage repair. Recently, several novel findings provided compelling evidence that Tβ4 played a key role in facilitating tumor metastasis and angiogenesis. It has been found that Tβ4 expressed increasingly in a number of metastatic tumors, which was associated with an increased expression of a known angiogenic factor, vascular endothelial growth factor. Thus, Tβ4 provided a potential target of opportunity for cancer management, especially for cancer metastasis therapy.
-
Fan Nai-Jun, Li Ke, Liu Qing-Yin, Wang Xiu-Li, Hu Liang, Li Jun-Tang, Gao Chun-Fang, Identification of tubulin beta chain, thymosin beta-4-like protein 3, and cytochrome b–c1 complex subunit 1 as serological diagnostic biomarkers of gastric cancer, Clinical Biochemistry, 46, 15, 2013. Crossref
-
Desiderio Claudia, Martelli Claudia, Rossetti Diana Valeria, Di Rocco Concezio, D’Angelo Luca, Caldarelli Massimo, Tamburrini Gianpiero, Iavarone Federica, Castagnola Massimo, Messana Irene, Cabras Tiziana, Faa Gavino, Identification of thymosins β4 and β10 in paediatric craniopharyngioma cystic fluid, Child's Nervous System, 29, 6, 2013. Crossref
-
Jackson Kenneth W., Christiansen Victoria J., Yadav Vivek R., Silasi-Mansat Robert, Lupu Florea, Awasthi Vibhudutta, Zhang Roy R., McKee Patrick A., Suppression of Tumor Growth in Mice by Rationally Designed Pseudopeptide Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase, Neoplasia, 17, 1, 2015. Crossref
-
Martelli Claudia, Iavarone Federica, D'Angelo Luca, Arba Morena, Vincenzoni Federica, Inserra Ilaria, Delfino Daniela, Rossetti Diana Valeria, Caretto Marta, Massimi Luca, Tamburrini Gianpiero, Di Rocco Concezio, Caldarelli Massimo, Messana Irene, Castagnola Massimo, Sanna Maria Teresa, Desiderio Claudia, Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study, Molecular BioSystems, 11, 6, 2015. Crossref
-
Cheung Belamy B., Tan Owen, Koach Jessica, Liu Bing, Shum Michael S.Y., Carter Daniel R., Sutton Selina, Po'uha Sela T., Chesler Louis, Haber Michelle, Norris Murray D., Kavallaris Maria, Liu Tao, O'Neill Geraldine M., Marshall Glenn M., Thymosin-β4 is a determinant of drug sensitivity for Fenretinide and Vorinostat combination therapy in neuroblastoma, Molecular Oncology, 9, 7, 2015. Crossref
-
Adami Guy R., O'Callaghan Thomas N., Kolokythas Antonia, Cabay Robert. J., Zhou Yalu, Schwartz Joel L., A loss of profilin-1 in late-stage oral squamous cell carcinoma, Journal of Oral Pathology & Medicine, 46, 7, 2017. Crossref
-
Gao Xiao-yu, Hou Fang, Zhang Zhi-peng, Nuo Ming-tu, Liang Hao, Cang Ming, Wang Zhi-gang, Wang Xin, Xu Teng, Yan Le-yan, Guo Xu-dong, Liu Dong-jun, Role of thymosin beta 4 in hair growth, Molecular Genetics and Genomics, 291, 4, 2016. Crossref
-
Massimi Luca, Martelli Claudia, Caldarelli Massimo, Castagnola Massimo, Desiderio Claudia, Proteomics in pediatric cystic craniopharyngioma, Brain Pathology, 27, 3, 2017. Crossref
-
Cho Kyung Sook, Kim Dong-Jin, Shim Bomee, Kim Jung Yeon, Kang Jun Mo, Park Seon Hwa, Lee Sang-Ho, Yang Hyung-In, Kim Kyoung Soo, An Investigation on the Therapeutic Effect of Thymosinβ4 and Its Expression Levels in Streptozotocin-Induced Diabetic Mice, BioMed Research International, 2018, 2018. Crossref
-
Feng Xiao-Wu, Huo Li-Jie, Yang Ming-Chong, Wang Jin-Xing, Shi Xiu-Zhen, Thymosins participate in antibacterial immunity of kuruma shrimp, Marsupenaeus japonicus, Fish & Shellfish Immunology, 84, 2019. Crossref
-
Kim Kyoung Soo, Yang Hyung-In, Thymosin β4 in rheumatoid arthritis: Friend or foe, Biomedical Reports, 7, 3, 2017. Crossref
-
Liu Yuan, Wang Yanan, Chen Chunqin, Zhang Jiawen, Qian Wenyan, Dong Yu, Liu Zhiqiang, Zhang Xi, Wang Xiaoyun, Zhang Zhenbo, Shi Xiaobing, Wu Sufang, LSD1 binds to HPV16 E7 and promotes the epithelial-mesenchymal transition in cervical cancer by demethylating histones at the Vimentin promoter, Oncotarget, 8, 7, 2017. Crossref
-
Sareddy Gangadhara R., Nair Binoj C., Krishnan Samaya K., Gonugunta Vijay K., Zhang Quan-guang, Suzuki Takayoshi, Miyata Naoki, Brenner Andrew J., Brann Darrell W., Vadlamudi Ratna K., KDM1 is a novel therapeutic target for the treatment of gliomas, Oncotarget, 4, 1, 2013. Crossref
-
Desiderio Claudia, Rossetti Diana Valeria, Castagnola Massimo, Massimi Luca, Tamburrini Gianpiero, Adamantinomatous craniopharyngioma: advances in proteomic research, Child's Nervous System, 37, 3, 2021. Crossref
-
Chao T-C, Chan L-C, Ju S-Y, Tang M-C, Liu C-Y, Chen P-M, Tzeng C-H, Su Y, In vivo growth suppression of CT-26 mouse colorectal cancer cells by adenovirus-expressed small hairpin RNA specifically targeting thymosin beta-4 mRNA, Cancer Gene Therapy, 21, 9, 2014. Crossref