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International Journal of Physiology and Pathophysiology

Erscheint 4 Ausgaben pro Jahr

ISSN Druckformat: 2155-014X

ISSN Online: 2155-0158

SJR: 0.116

siRNA-Mediated Silencing of 5-Lipoxygenase Gene (ALOX5) Reduces Necrosis of Cardiomyocytes at Anoxia- Reoxygenation

Volumen 1, Ausgabe 3, 2010, pp. 259-266
DOI: 10.1615/IntJPhysPathophys.v1.i3.70
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ABSTRAKT

In experiments on the primary culture of isolated neonatal rat cardiomyocytes it was determined that cardiomyocytes express ALOX5 gene encoding enzyme 5-lipoxygenase. Anoxia-reoxygenation does not affect significantly expression of 5-lipoxygenase mRNA in cardiomyocytes. Transfection into cardiomyocytes 5-lipoxygenase-specific small interfering RNA's (siRNA) lead to significant reducing of 5-lipoxygenase mRNA expression in cardiomyocytes after 24 hours of cultivation. ALOX5 gene silencing resulted in improved cell survival during anoxia-reoxygenation. Obtained results indicate that siRNA against ALOX5 effectively protects cardiomyocytes against A/R injury.

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