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ISSN Druckformat: 2155-014X
ISSN Online: 2155-0158
Endothelial Monocyte-Activating Polypeptide-II: Properties, Functions, and Pathogenetic Significance
ABSTRAKT
Endothelial dysfunction is implicated in the pathogenesis of diabetes and atherosclerosis. Endothelial monocyte-activating polypeptide-II (EMAP-II) is a multifunctional polypeptide with proinflammatory and antiangiogenic activities. EMAP-II induces procoagulant activity on the surface of endothelial cells, increases expression of E- and P-selectins and tumor necrosis factor-1, directs migration of monocytes and neutrophils, and induces apoptosis in endothelial cells. The review provides insight into the history of EMAP-II, structural modules, functional domains, biological properties and functions of the polypeptide, mechanisms of action and proinflammatory effects on endothelial cells, anti-tumor properties, pathogenic role in diseases of the central nervous system, contribution to the development of the lungs during embryogenesis and pathogenetic significance in lung diseases, the development of cardiovascular lesions.
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DOROFEYEVA N.A., VOROBYOV G.G., CHEREPAHA I.Y., KORNELYUK A.I., SAGACH V.F., Endothelial monocyte-activating polypeptide-ii improves diastolic heart function and vascular relaxation in Streptozotocin-induced experimental diabetes, Fiziolohichnyĭ zhurnal, 63, 6, 2017. Crossref