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ISSN Druckformat: 2155-014X
ISSN Online: 2155-0158
Efficiency of Bisphosphonic Acids in Female Rats with Experimental Osteoporosis
ABSTRAKT
We evaluated the efficiency of different bisphosphonic acids, including ethylidenebisphosphonic (EBP), aminoethylidenebisphosphonic (AEBP), 1-phenyl-1-hydroxymethylenebisphosphonic (PhHMBP), and 1 -phenyl- 1-fluoro- methylenebisphosphonic (PhFMBP) acids on the bone mineral density and bone mineral content in female rats with experimental osteoporosis, compared to zoledronic acid in combination with calcium and vitamin D supplementation. The results indicate the absence of significant changes in bone mineral density indexes in female rats after bilateral ovariectomy, treated with EBF, AEBF, and PhHMBP in combination with calcium and vitamin D supplements. Significant dynamics of bone mineral density of total skeleton [from (0.100 ± 0.007) to (0.105 ± 0.008) g/cm2 after 3 months] in the rats treated with combined PhFMBP, calcium, and vitamin D administration requires further exploration of PhFMBP effectiveness in prevention and treatment of systemic osteoporosis.