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International Journal of Medicinal Mushrooms

Erscheint 12 Ausgaben pro Jahr

ISSN Druckformat: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Combination Therapy of Transplanted Meth-A Fibrosarcoma in BALB/c Mice with Protein-Bound Polysaccharide EA6 Isolated from Enokitake Mushroom Flammulina velutipes (W.Curt.:Fr.)Singer and Surgical Excision

Volumen 7, Ausgabe 1&2, 2005, pp. 213-220
DOI: 10.1615/IntJMedMushr.v7.i12.200
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ABSTRAKT

The present study demonstrates the antitumor effect of treatment combining protein-bound polysaccharide EA6 isolated from culinary—medicinal mushroom Flammulina velutipes with surgical excision (SE) in mice using Meth-A fibrosarcoma. Oral administration of EA6 alone exhibited no inhibitory effect on the growth of intradermally inoculated Meth-A tumor cells, although it was effective for increasing the lifespan in mice bearing Lewis lung carcinoma or B-16 melanoma. In Meth-A fibrosarcoma, EA6, when administered orally, displayed a marked antitumor effect against the same tumor rechallenged after SE. When oral administration of EA6 (10 mg/kg/day) was begun on post-excision day 1, the growth of the secondary tumor inoculated on post excision day 7 was significantly inhibited. When mice showed this inhibitory effect for the second solid tumor challenged, immune activity of the mice was tested. EA6 was found to enhance both humoral (i.e., antibody response to sheep red blood cells) and cell-mediated (i.e., anti-Meth-A delayed-type hypersensitivity response) immunity. In tumor neutralization tests, the spleen cells from mice treated with both EA6 and SE markedly inhibited the growth of admixed Meth-A tumor cells. The antitumor immunity of the spleen cells was eliminated by treatment with anti-CD4 monoclonal antibody plus complement, but not with anti-CD8 monoclonal antibody plus complement. These results suggest that EA6 augments the antitumor immunity in combination with SE, and the effect is mediated by CD4-positive T cells.

REFERENZIERT VON
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