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ISSN Druckformat: 1521-9437
ISSN Online: 1940-4344
Indexed in
Evaluation of Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al., Aqueous Extract in Mice Challenged with Salmonella enterica Serovar Typhimurium
ABSTRAKT
This study investigated the effects of Agaricus brasiliensis S. Wasser et al. (= Agaricus blazei Murrill sensu Heinem.) aqueous extract on small intestinal sIgA levels, serum TNF-α, IFN-γ and IL-10 levels, splenic index, bacterial translocation, and histology of small intestine, spleen, and liver from mice orally challenged with 106 CFU of Salmonella enterica serovar Typhimurium (SEST). Splenic index values as well as sIgA, TNF-α, IFN-γ and IL-10 levels were not affected by either A. brasiliensis aqueous extract treatment or by pathogenic challenge. Typical colonies of SEST were recovered from liver, spleen, and mesenteric lymph nodes of challenged animals, but there was no significant difference in this translocation between groups treated or not with A. brasiliensis aqueous extract. Translocation was confirmed by histopathological analysis in mice challenged with SEST, which showed small and diffuse foci of mixed inflammatory infiltrate in hepatic parenchyma. In conclusion, A. brasiliensis aqueous extract as tested in the present study did not influence any of the variables selected to evaluate in vivo its immunomodulatory effect suggested in the literature.
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Soković Marina, Ćirić Ana, Glamočlija Jasmina, Nikolić Miloš, van Griensven Leo, Agaricus Blazei Hot Water Extract Shows Anti Quorum Sensing Activity in the Nosocomial Human Pathogen Pseudomonas Aeruginosa, Molecules, 19, 4, 2014. Crossref
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Soković Marina, Glamočlija Jasmina, Ćirić Ana, Petrović Jovana, Stojković Dejan, Mushrooms as Sources of Therapeutic Foods, in Therapeutic Foods, 2018. Crossref
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Glamočlija Jasmina, Ćirić Ana, Nikolić Miloš, Fernandes Ângela, Barros Lillian, Calhelha Ricardo C., Ferreira Isabel C.F.R., Soković Marina, van Griensven Leo J.L.D., Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”, Journal of Ethnopharmacology, 162, 2015. Crossref