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International Journal of Medicinal Mushrooms

Erscheint 12 Ausgaben pro Jahr

ISSN Druckformat: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Comparison of the Immunomodulating Activities of 1,3-β-glucan Fractions from the Culinary-Medicinal Mushroom Sparassis crispa Wulf.:Fr. (Aphyllophoromycetideae)

Volumen 8, Ausgabe 3, 2006, pp. 231-244
DOI: 10.1615/IntJMedMushr.v8.i3.50
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ABSTRAKT

Sparassis crispa is a culinary-medicinal mushroom recently cultivated in Japan, China, Germany, and the U.S. In a previous study, we purified a 6-branched 1,3-β-D-glucan preparation, designated as SCG, and investigated its biological activities. In the present study, we prepared polysac-charide fractions extracted from S. crispa by hot water (SCHWE), cold NaOH (SCG), and hot NaOH (SCHA), and investigated their properties and immunomodulating activities. These polysaccharide fractions showed strong limulus factor G activity due to the presence of β-1,3-D-glucans. They also showed a strong antitumor activity against the solid form of Sarcoma 180 in ICR mice, and hemato-poietic response in cyclophosphamide-induced leukopenic mice. They induced the splenocytes from DBA/2 mice to produce GM-CSF, TNF-α, and IFN-γ in vitro. By treatment with sodium hydroxide of SCHWE, the hematopietic response was enhanced but cytokine induction was decreased. Taken together, these results strongly suggested that the preparation method was related to the conformation of the β-glucan fraction, and the immunomodulating activities in vivo and in vitro were significantly modulated by the preparation methods.

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