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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Reversal of Methylmercury-Induced Oxidative Stress, Lipid Peroxidation, and DNA Damage by the Treatment of N-Acetyl Cysteine: A Protective Approach

Volume 33, Issue 2, 2014, pp. 167-182
DOI: 10.1615/JEnvironPatholToxicolOncol.2014010291
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ABSTRACT

This study was designed to evaluate the protective effect of N-acetyl cysteine in reducing methylmercury (MeHg)−induced oxidative stress, lipid peroxidation, DNA damage in liver, kidney, and brain, and their ability to restore altered hepatic, renal, and other biochemical variables. Male Sprague-Dawley rats (150 ± 10 g) were randomly divided into three groups. Group 1 served as the control. Groups 2 and 3 were administered methylmercury (1 mg kg−1 orally, 5 days/week) for 12 weeks, and group 2 served as the experimental control. Group 3 received N-acetyl cysteine (0.6 mg kg−1 intraperitoneally, two days/week) for 12 weeks after methylmercury exposure. Methylmercury exposure caused a significant rise in bilirubin, gamma-glutamyl transpeptidase, protein, triglycerides, cholesterol, urea, creatinine, uric acid, and blood urea nitrogen, with a concomitant decrease in albumin content, reduced glutathione level and acetyl cholinesterase activity, antioxidant enzymes such as glutathione reductase, glutathione peroxidase, glucose-6-phosphate dehydrogenase, and adenosine triphosphatase. However, lipid peroxidation level, metallothionein expression, and DNA damage with increment of tail length were observed after methylmercury intoxication. N-acetyl cysteine, a widely available, nontoxic amino acid derivative, is a promising antioxidant with a wide spectrum of biological functions. The ability of N-acetyl cysteine to enhance mercury excretion and its wide availability in clinical use indicate that it may be an ideal therapeutic agent against methylmercury poisoning.

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  2. Rodrigues Juan, Branco Vasco, Lu Jun, Holmgren Arne, Carvalho Cristina, Toxicological effects of thiomersal and ethylmercury: Inhibition of the thioredoxin system and NADP+-dependent dehydrogenases of the pentose phosphate pathway, Toxicology and Applied Pharmacology, 286, 3, 2015. Crossref

  3. Wang Xinjin, Yan Mengling, Zhao Lina, Wu Qing, Wu Chunhua, Chang Xiuli, Zhou Zhijun, Low-Dose Methylmercury-Induced Apoptosis and Mitochondrial DNA Mutation in Human Embryonic Neural Progenitor Cells, Oxidative Medicine and Cellular Longevity, 2016, 2016. Crossref

  4. Wu Qin, Li Wen-Kai, Zhou Zheng-Ping, Li Ying-Ying, Xiong Ting-Wan, Du Yi-Zhi, Wei Li-Xin, Liu Jie, The Tibetan medicine Zuotai differs from HgCl2 and MeHg in producing liver injury in mice, Regulatory Toxicology and Pharmacology, 78, 2016. Crossref

  5. Siddiqui Amir, Akhtar Juber, Uddin M.S. Shahab, Khan Mohammad Irfan, Khalid Mohammad, Ahmad Mohammad, A Naturally Occurring Flavone (Chrysin): Chemistry, Occurrence, Pharmacokinetic, Toxicity, Molecular Targets and Medicinal Properties, Journal of Biologically Active Products from Nature, 8, 4, 2018. Crossref

  6. Abarikwu Sunny O., Njoku Rex-Clovis C., Onuah Chigozie L., Aged coconut oil with a high peroxide value induces oxidative stress and tissue damage in mercury-treated rats, Journal of Basic and Clinical Physiology and Pharmacology, 29, 4, 2018. Crossref

  7. Pellacani C., Costa L.G., Role of autophagy in environmental neurotoxicity, Environmental Pollution, 235, 2018. Crossref

  8. Branco Vasco, Pimentel José, Brito Maria Alexandra, Carvalho Cristina, Thioredoxin, Glutathione and Related Molecules in Tumors of the Nervous System, Current Medicinal Chemistry, 27, 12, 2020. Crossref

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  10. Garcia M. S., Orcini W. A., Peruquetti R. L., Perobelli J. E., New approach for reproductive toxicity assessment: chromatoid bodies as a target for methylmercury and polychlorinated biphenyls in prepubertal male rats, Reproduction, Fertility and Development, 32, 10, 2020. Crossref

  11. de Oliveira Lopes Géssica, Aragão Walessa Alana Bragança, Bittencourt Leonardo Oliveira, Puty Bruna, Lopes Armando Pereira, dos Santos Sávio Monteiro, Monteiro Marta Chagas, de Oliveira Edivaldo Herculano Corrêa, da Silva Márcia Cristina Freitas, Lima Rafael Rodrigues, Imaging Microstructural Damage and Alveolar Bone Loss in Rats Systemically Exposed to Methylmercury: First Experimental Evidence, Biological Trace Element Research, 199, 10, 2021. Crossref

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  13. Li Xiaoyang, Pan Jingjing, Wei Yanfeng, Ni Linlin, Xu Bin, Deng Yu, Yang Tianyao, Liu Wei, Mechanisms of oxidative stress in methylmercury-induced neurodevelopmental toxicity, NeuroToxicology, 85, 2021. Crossref

  14. Dong Lihua, Yang Bobo, Zhang Yu, Wang Suhua, Li Fang, Xing Guangwei, Farina Marcelo, Zhang Yubin, Appiah-Kubi Kwaku, Tinkov Alexey A., Aschner Michael, Shi Haifeng, Liu Tingting, Lu Rongzhu, Ferroptosis contributes to methylmercury-induced cytotoxicity in rat primary astrocytes and Buffalo rat liver cells, NeuroToxicology, 90, 2022. Crossref

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  16. Nogueira Lygia S., Vasconcelos Carolina P., Mitre Geovanni Pereira, Kataoka Maria Sueli da Silva, Bittencourt Leonardo Oliveira, Lima Marcelo O., de Oliveira Edivaldo H.C., Crespo-Lopez Maria Elena, Lima Rafael Rodrigues, Metabolic and oxidative impairments in human salivary gland cells line exposed to MeHg, Journal of Trace Elements in Medicine and Biology, 66, 2021. Crossref

  17. Augustyniak J., Lipka G., Kozlowska H., Caloni F., Buzanska L., Oxygen as an important factor modulating in vitro MeHgCl toxicity associated with mitochondrial genes in hiPSCs, Ecotoxicology and Environmental Safety, 241, 2022. Crossref

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