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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Radioprotective Potential of Rosemarinus officinalis against Lethal Effects of Gamma Radiation : A Preliminary Study

Volume 25, Issue 4, 2006, pp. 633-642
DOI: 10.1615/JEnvironPatholToxicolOncol.v25.i4.30
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ABSTRACT

The radioprotective effect of Rosemarinus officinalis extract (ROE) was studied in mice exposed to 8 Gy of gamma radiation. The optimum dose for radioprotection was determined by administering 100, 200, 400, 800, 1000, 1500, and 2000 mg/kg body weight of ROE orally once daily, consecutively for five days before irradiation. Treatment of mice with ROE, delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug-treated irradiated controls. The dose of ROE found to be most effective against radiation was 1000 mg/kg body weight because this dose increased the survival time and reduced the mortality rate of mice significantly. Body weight loss in ROE administered irradiated animals was significantly less in comparison with animals who were given radiation treatment alone. Furthermore, irradiation of animals resulted in an elevation in lipid peroxidation (LPx) and a significant decrease in glutathione (GSH) in blood and liver. Conversely, administration of animals with ROE before irradiation caused a significant decline in LPx accompanied by a significant increase in GSH concentration. The present study demonstrates that Rosemarinus officinalis leave extract is a good radioprotector.

CITED BY
  1. Tung David, Cheung Peter H., Wilson James, Tudor Gregory, Booth Catherine, Saha Saurabh, Differential Effects of Cyclosporin and Etanercept Treatment on Various Pathologic Parameters in a Murine Model of Irradiation-Induced Mucositis, Current Therapeutic Research, 73, 4-5, 2012. Crossref

  2. Sharma Priyanka, Parmar Jyoti, Sharma Priyanka, Verma Preeti, Goyal P. K., Radiation-Induced Testicular Injury and Its Amelioration byTinospora cordifolia(An Indian Medicinal Plant) Extract, Evidence-Based Complementary and Alternative Medicine, 2011, 2011. Crossref

  3. Kindekov Ivan, Mileva Milka, Krastev Dimo, Vassilieva Vladimira, Raynova Yuliana, Doumanova Lyuba, Aljakov Mitko, Idakieva Krassimira, Radioprotective effect ofRapana thomasianahemocyanin in gamma induced acute radiation syndrome, Biotechnology & Biotechnological Equipment, 28, 3, 2014. Crossref

  4. Nambiar Dhanya, Rajamani Paulraj, Singh Rana P., Effects of phytochemicals on ionization radiation-mediated carcinogenesis and cancer therapy, Mutation Research/Reviews in Mutation Research, 728, 3, 2011. Crossref

  5. Verma Preeti, Jahan Swafiya, Kim Tae-Hawn, Goyal Pradeep Kumar, Management of Radiation Injuries by Panax ginseng Extract, Journal of Ginseng Research, 35, 3, 2011. Crossref

  6. Alvi Sahir Sultan, Ahmad Parvej, Ishrat Maleeha, Iqbal Danish, Khan M. Salman, Secondary Metabolites from Rosemary (Rosmarinus officinalis L.): Structure, Biochemistry and Therapeutic Implications Against Neurodegenerative Diseases, in Natural Bio-active Compounds, 2019. Crossref

  7. Soyal Dhanraj, Jindal Archana, Singh Inder, Goyal P.K., Modulation of radiation-induced biochemical alterations in mice by rosemary (Rosemarinus officinalis) extract, Phytomedicine, 14, 10, 2007. Crossref

  8. Emamgholizadeh Minaei Soraya, Hoseini Farideh, The Role of Radioprotector Agents in the Protection of Normal tissue, Journal of Research in Applied and Basic Medical Sciences, 7, 3, 2021. Crossref

  9. Estaphan Suzanne, Abdel‐Malek Raafat, Rashed Laila, Mohamed Enas Ahmed, Cimetidine a promising radio‐protective agent through modulating Bax/Bcl2 ratio: An in vivo study in male rats, Journal of Cellular Physiology, 235, 11, 2020. Crossref

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