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Journal of Environmental Pathology, Toxicology and Oncology

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ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Radioadaptive Response in Human Lymphocytes in Vitro

Volume 20, Issue 3, 2001, 11 pages
DOI: 10.1615/JEnvironPatholToxicolOncol.v20.i3.10
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ABSTRACT

Exposure to low doses of radiation and/or chemicals can prime an organism to withstand the stress of a subsequent exposure to higher doses of the same agent. In the case of radiation, this phenomenon has been called radioadaptive response. Cytogenetic studies have been undertaken in human lymphocytes to investigate adaptive response (AR) to ionizing radiation, in particular to seek the role of variables such as priming dose, cell cycle stage, and age and gender of the donor. We demonstrated that pre-exposure of lymphocytes in whole blood cultures to very low doses in the range of about 1 cGy (priming or adaptive dose [AD]) reduced the frequency ofmicronuclei in binucleated cells induced by 100 cGy— that is, produced an AR in these cells in vitro. However, pre-exposure of cells to 10.0 cGy did not reduce the chromosomal damage (micronuclei) induced by the challenging dose (CD) of 100 cGy under the same protocol, thus exhibiting an inverse dose-response relationship. There was marked variability in the AR among the individuals investigated in the study. The extent of AR also depended on the stage of cell cycle exposed to the CD of radiation. Maximum AR was observed when CD of 100 cGy was given 4 hours after AD, 30 hours following the mitogenic stimulation of lymphocytes. The least AR was observed when CD was given 48 hours after stimulation. Interestingly, AR was also found to be dependent on the age of the donor, a decrease in AR being observed with an increasing age. No significant difference in AR was observed between male and female donors.
To understand the molecular events underlying AR, protein synthesis patterns were studied in human lymphocytes subjected to mitogen, heat, or radiation stress. Heat shock (45 °C, for 15 min) induced 7 proteins with molecular weights ranging from 40 to 80 kDa, while treatment with phytohemagglutinin (40 mg/mL) showed induction of 2 proteins of molecular weights 38 and 48 kDa, respectively. However, exposure of human lymphocyte cultures to gamma radiation did not significantly induce synthesis of any protein, up to 800 cGy dose. Lack of induction of proteins by gamma radiation in human lymphocytes contrasts with the previous reports showing X-ray radiation-enhanced gene expression in melanoma cells and/or human tumor fibroblasts.

CITED BY
  1. Schaffer Moshe, Schwarz Silke B., Kulka Ulrike, Busch Martin, D�hmke Eckhart, Adaptive doses of irradiation?an approach to a new therapy concept for bladder cancer?, Radiation and Environmental Biophysics, 43, 4, 2004. Crossref

  2. Miura Yuri, Endo Tamao, Survival responses to oxidative stress and aging, Geriatrics & Gerontology International, 10, 2010. Crossref

  3. Schaffer Moshe, Balandin Alina, Ertl-Wagner Birgit, Schaffer Pamela, Bonavina Luigi, Hofstette Alfons, Kulka Ulrike, Does Photofrin II Combined with a Radio-Adaptive Dose Lead to a Synergistic or Additive Effect after Ionising Irradiation <i>In Vitro</i>?, Journal of Cancer Therapy, 02, 04, 2011. Crossref

  4. Grillo Claudia A., Dulout Fernando N., Güerci Alba M., Evaluation of radioadaptive response induced in CHO-K1 cells in a non-traditional model, International Journal of Radiation Biology, 85, 2, 2009. Crossref

  5. Hou Jue, Wang Fan, Kong Peizhong, Yu Peter K. N., Wang Hongzhi, Han Wei, Yuan Zhi-Min, Gene Profiling Characteristics of Radioadaptive Response in AG01522 Normal Human Fibroblasts, PLOS ONE, 10, 4, 2015. Crossref

  6. BAE SEUNGHEE, KIM KARAM, CHA HWA JUN, CHOI YEONGMIN, SHIN SHANG HUN, AN IN-SOOK, LEE JAE HO, SONG JIE-YOUNG, YANG KWANG HEE, NAM SEON YOUNG, AN SUNGKWAN, Altered microRNA expression profiles are involved in resistance to low-dose ionizing radiation in the absence of BMI1 in human dermal fibroblasts, International Journal of Oncology, 45, 4, 2014. Crossref

  7. Dimova Evgeniya G., Bryant Peter E., Chankova Stephka G., Adaptive response: some underlying mechanisms and open questions, Genetics and Molecular Biology, 31, 2, 2008. Crossref

  8. Coleman Matthew A., Yin Eric, Peterson Leif E., Nelson David, Sorensen Karen, Tucker James D., Wyrobek Andrew J., Low-Dose Irradiation Alters the Transcript Profiles of Human Lymphoblastoid Cells Including Genes Associated with Cytogenetic Radioadaptive Response, Radiation Research, 164, 4, 2005. Crossref

  9. Wang Xiao-Chun, Tian Li-Li, Fan Cai-Xia, Duo Cai-Hong, Xu Ke-Ming, The Adaptive Responses in Non-Small Cell Lung Cancer A549 Cell Lines Induced by Low-Dose Ionizing Radiation and the Variations of miRNA Expression, Dose-Response, 19, 4, 2021. Crossref

  10. Chakrabarti Manoswini, Mukherjee Anita, Metallo-adaptive response: a unique survival strategy of plants under genotoxic stress, The Nucleus, 65, 1, 2022. Crossref

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